GlobalRPh Renal Dosing Masterv6.6
GlobalRPh source record

Tenofovir disoproxil fumarate (Viread)

GlobalRPh source pageBase record retrieved 2026-09-05See the evidence for this drug2 sources available - open source summaries, references and comparisons
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Renal guidance at a glance

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Professional source

NIH adult ARV table - tenofovir disoproxil fumarate

Product / population
Adults; source-specific institutional guidance. Match route, indication and renal replacement modality.
Renal measure
CrCl mL/min; single-agent TDF only

Dosing / renal protocol and limits

Single-agent TDF: usual 300 mg orally daily. CrCl 30-49: 300 mg every 48 hours; 10-29: 300 mg every 72-96 hours; <10 without HD: no recommendation. HD: 300 mg every 7 days after dialysis. Do not apply this to TAF or fixed combinations.

Source revision: Revision date not stated in the reviewed page. | Retrieved: 2026-09-05. Retrieval date is not the revision date.

Source: https://clinicalinfo.hiv.gov/en/guidelines/hiv-clinical-guidelines-adult-and-adolescent-arv/drug-characteristics-tables-renal-hepatic-insufficiency-full

Scope: Locally included source-specific summary. Regimen differences are not automatically resolved. GlobalRPh v6.6.

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Evidence sources and renal implications

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Preserved GlobalRPh source

Preserved original GlobalRPh source

Preserved historical content; not revalidated as current prescribing guidance.

Renal method: Read the measure and population stated in the original source sections.
Retrieved: 2026-09-05

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Professional guidance

NIH adult ARV table - tenofovir disoproxil fumarate

Adults; source-specific institutional guidance. Match route, indication and renal replacement modality.

Renal method: CrCl mL/min; single-agent TDF only
Retrieved: 2026-09-05

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Renal dosing and precautions

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Original content / product scopeNIH adult ARV table - tenofovir disoproxil fumarate
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Historical source content is not a current prescription. Original GlobalRPh recommendations are preserved, not automatically certified as current. Product-label and professional additions below are separately attributed. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.

Important source distinctions

Tenofovir disoproxil fumarate 300 mg only, not tenofovir alafenamide or a fixed-dose combination.

The NIH addition is specifically tenofovir disoproxil fumarate (TDF). Do not apply it to tenofovir alafenamide (TAF) or a fixed-dose combination.

Locally stored source content

Original GlobalRPh protocol

Clinical facts and comments transcribed into a structured reading format. This is not a byte-for-byte HTML archive. Original source: https://globalrph.com/renal/tenofovir/

Usual Dosing (Adults)

VIREAD for HIV-1 or chronic hepatitis B: 300 mg orally once daily, without regard to food. The source states the optimal HBV treatment duration is unknown.

GRPH-tenofovir-01 · Source section: Usual Dosing (Adults)Renal section finder

Renal Dosing

CrCl above 50 mL/min: usual dose. 30-49: 300 mg every 48 hours. 10-29: 300 mg twice weekly. Below 10 without dialysis: no recommendation available. Exactly 50 is not explicitly assigned in the original text.

GRPH-tenofovir-02 · Source section: Renal DosingRenal section finder

Hemodialysis

300 mg every 7 days or after a total of 12 hours of dialysis, usually weekly assuming three 4-hour sessions.

GRPH-tenofovir-03 · Source section: HemodialysisRenal section finder
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University and professional protocols

Professional

NIH adult ARV table - tenofovir disoproxil fumarate

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NIH ClinicalInfo adult ARV panel · Adults; source-specific institutional guidance. Match route, indication and renal replacement modality.

Renal method: CrCl mL/min; single-agent TDF only
Source date: Revision date not stated in the reviewed page.
Retrieved: 2026-09-05

Locally included source-specific summary. Regimen differences are not automatically resolved.

Dosing / renal protocol and limits

Single-agent TDF: usual 300 mg orally daily. CrCl 30-49: 300 mg every 48 hours; 10-29: 300 mg every 72-96 hours; <10 without HD: no recommendation. HD: 300 mg every 7 days after dialysis. Do not apply this to TAF or fixed combinations.

RDM30-099-tenofovir-1 · Source locator: NIH adult ARV table - tenofovir disoproxil fumarate; renal/dosing sections and stated qualifiers

Source identity and provenance
Source
https://clinicalinfo.hiv.gov/en/guidelines/hiv-clinical-guidelines-adult-and-adolescent-arv/drug-characteristics-tables-renal-hepatic-insufficiency-full
Retrieved
2026-09-05
Renal-function method
CrCl mL/min; single-agent TDF only
Source date/version
Revision date not stated in the reviewed page.
Hash meaning
Locally authored summary text; not original SPL, HTML or PDF bytes
Local summary SHA-256
cdbdb281aa4fa64962797b211eaf68b5717d270c820600094140fe8e2036fdf5

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 0 RX List, 1 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://globalrph.com/renal/tenofovir/
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
globalrph individual
Local text SHA-256
68be60700a0323930534ca36875fc024bb07b9000bf221ba51dbcd8c9f264676
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

The original individual GlobalRPh pages commonly cite NIH/NLM DailyMed and instruct readers to review the applicable package insert for updates. That historical reference is preserved as context; it is not counted as an independently retrieved current label.

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