GlobalRPh Renal Dosing Masterv6.6
Evidence addition

Telotristat ethyl tablets (Xermelo)

Local official-label summaryBase record retrieved 2026-09-05See the evidence for this drug2 sources available - open source summaries, references and comparisons

Xermelo

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Official source

Telotristat ethyl tablets (Xermelo) - selected U.S. label sections

Product / population
Adult XERMELO oral tablets for the labeled carcinoid-syndrome diarrhea indication.
Renal measure
Qualitative mild/moderate/severe impairment; ESRD dialysis evidence gap.

Selected renal sections only, not a complete monograph. Exact product, indication, patient population, renal method and all other contraindications/interactions remain controlling.

Second independent renal reference and clinician adjudication remain pending; no all-indication, dialysis or pediatric dose may be inferred from an omitted field.

Renal and dialysis comments

No adjustment is necessary for mild, moderate or severe impairment in patients not requiring dialysis. There is no information for end-stage renal disease requiring dialysis. The non-dialysis recommendation must not be extended to dialysis by assumption.

Source revision: Revision not captured; retrieval date is not the revision date. | Retrieved: 2026-09-05. Retrieval date is not the revision date.

Source: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a4ac9d62-887c-4c8f-b04d-a5f31cec7c86

Scope: Local label summary; independent clinical review pending. Not a two-source validated protocol. GlobalRPh v6.6.

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Evidence sources and renal implications

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Official product label

Telotristat ethyl tablets (Xermelo) - selected U.S. label sections

Adult XERMELO oral tablets for the labeled carcinoid-syndrome diarrhea indication.

Renal method: Qualitative mild/moderate/severe impairment; ESRD dialysis evidence gap.
Retrieved: 2026-09-05

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GlobalRPh RX List

GlobalRPh RX List - XERMELO

No adjustment within stated limits. This does not establish dosing outside the studied renal range or population.

Telotristat ethyl tablets (XERMELO); selected renal comments only. Confirm indication, age, formulation and current product label.

Renal method: Indexed eGFR and dialysis status.
Retrieved: 2026-09-07

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New source summary - independent clinical review pending. Summaries of the identified label sections are included locally. Source import and numeric transcription checks are not independent two-reference validation. Do not treat this card as an approved institutional dosing protocol.
Official source

Telotristat ethyl tablets (Xermelo) - selected U.S. label sections

Adult XERMELO oral tablets for the labeled carcinoid-syndrome diarrhea indication.

Method: Qualitative mild/moderate/severe impairment; ESRD dialysis evidence gap.

Renal and dialysis commentsRead this complete source summary

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Original content / product scopeTelotristat ethyl tablets (Xermelo) - selected U.S. label sectionsGlobalRPh RX List - XERMELO
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Exact product and population matter. This added page contains locally stored, source-specific clinical summaries. Historical handbook information, when present, is identified separately and may conflict with U.S. labeling. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.
Locally stored source content

Exact product and population

Product identity selected for the separately displayed source protocols below. Reference: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a4ac9d62-887c-4c8f-b04d-a5f31cec7c86

Product and population scope

Adult XERMELO oral tablets for the labeled carcinoid-syndrome diarrhea indication.

RDM32-telotristat-xermelo-scope · Source section: Editorial scope for the selected U.S. labelRenal section finder
Separate U.S. product-label layer

FDA / DailyMed dosing and renal information

Official

Telotristat ethyl tablets (Xermelo) - selected U.S. label sections

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U.S. product labeling / DailyMed · Adult XERMELO oral tablets for the labeled carcinoid-syndrome diarrhea indication.

Renal method: Qualitative mild/moderate/severe impairment; ESRD dialysis evidence gap.
Source date: Revision not captured; retrieval date is not the revision date.
Retrieved: 2026-09-05

Local label summary; independent clinical review pending. Not a two-source validated protocol.

Renal and dialysis comments

No adjustment is necessary for mild, moderate or severe impairment in patients not requiring dialysis. There is no information for end-stage renal disease requiring dialysis. The non-dialysis recommendation must not be extended to dialysis by assumption.

RDM32-telotristat-xermelo-1 · Source locator: 8.6

Source-specific limits

Selected renal sections only, not a complete monograph. Exact product, indication, patient population, renal method and all other contraindications/interactions remain controlling.

Second independent renal reference and clinician adjudication remain pending; no all-indication, dialysis or pediatric dose may be inferred from an omitted field.

Source identity and provenance
Source
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a4ac9d62-887c-4c8f-b04d-a5f31cec7c86
Retrieved
2026-09-05
DailyMed Set ID
a4ac9d62-887c-4c8f-b04d-a5f31cec7c86
Renal-function method
Qualitative mild/moderate/severe impairment; ESRD dialysis evidence gap.
Source date/version
Revision not captured; retrieval date is not the revision date.
Hash meaning
SHA-256 identifies this local summary, not original SPL XML or a label PDF.
Local summary SHA-256
c32483b6e744be3389ff957dc9a7c0d8a6e0fcdba510b7ea4304a8a155cbdcb8
Locally imported selected renal sections

GlobalRPh RX List renal information

Rxlist

GlobalRPh RX List - XERMELO

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GlobalRPh-hosted RX List · Telotristat ethyl tablets (XERMELO); selected renal comments only. Confirm indication, age, formulation and current product label.

Renal method: Indexed eGFR and dialysis status.
Source date: Source revision date not established in selected retrieval.
Retrieved: 2026-09-07

Label mirror, not independent corroboration. This is selected locally stored RX List content. Full monograph import and current official-label review are not implied.
No adjustment within stated limits. This does not establish dosing outside the studied renal range or population.

Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.

Renal dosing, restrictions and evidence limits

No dose adjustment is required for mild, moderate or severe renal impairment in patients not requiring dialysis. No information is available for end-stage renal disease requiring dialysis (source eGFR <15 mL/min/1.73 m2). Preserve the nondialysis condition; it is not a hemodialysis recommendation.

RDM35-rxlist-telotristat-xermelo-9c72cf280c-C1 · Source locator: Renal impairment; dosage; warnings; pharmacokinetics, as identified in the selected retrieval.

Source identity and provenance
Source family
product_label_mirror
Source
https://globalrph.com/rx-list/xermelo-drug/
Retrieved
2026-09-07
Renal-function method
Indexed eGFR and dialysis status.
Source date/version
Source revision date not established in selected retrieval.
Hash meaning
SHA-256 of local authored summary only; not original HTML, PDF or SPL bytes.
Local summary SHA-256
bdb5d768fe4f85839d21b7986b1c0ae2d1e7d45eebe2494b95d38d9a527f120f

Provenance and preservation

Additional summaries stored on this page: 1 official-label, 1 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a4ac9d62-887c-4c8f-b04d-a5f31cec7c86
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
multisource addition
Local text SHA-256
1fa3d6ef86f9ac6e00b2f3963ca1fedacd60ee6d0e49c51ffee79c5d46695180
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

This page is an additional exact-product entry, not a recovered GlobalRPh monograph. Its primary scope text and separately attributed clinical summaries are locally included.

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