GlobalRPh Renal Dosing Masterv6.6
GlobalRPh source record

Streptomycin

GlobalRPh source pageBase record retrieved 2026-09-05See the evidence for this drug1 sources available - open source summaries, references and comparisons
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Renal measure
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Historical dose/interval summary; not a substitute for a current indication-specific regimen, toxicity assessment and therapeutic drug monitoring.

Usual Dosing (Adults)

Tuberculosis daily therapy: 15 mg/kg/day IM, maximum 1 g. Twice-weekly directly observed therapy: 25-30 mg/kg IM, maximum 1.5 g. Three-times-weekly DOT: 25-30 mg/kg IM, maximum 1 g. Historical streptococcal endocarditis regimen: 1 g IM/IV every 12 hours for 7 days, then 500 mg every 12 hours for 1 week.

Renal Dosing

CrCl above 50 mL/min: every 24 hours. 10-50: every 24-72 hours. Below 10: every 72-96 hours.

Hemodialysis

Use the below-10 regimen; give after dialysis on dialysis days.

Source revision: Historical source; revision not established here | Retrieved: 2026-09-05. Retrieval date is not the revision date.

Source: https://globalrph.com/renal/streptomycin/

Scope: Preserved historical source; no fresh clinical approval GlobalRPh v6.6.

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Preserved GlobalRPh source

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Retrieved: 2026-09-05

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Renal dosing and precautions

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Original content / product scope
Historical source content is not a current prescription. Original GlobalRPh recommendations are preserved, not automatically certified as current. Product-label and professional additions below are separately attributed. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.

Important source distinctions

Historical dose/interval summary; not a substitute for a current indication-specific regimen, toxicity assessment and therapeutic drug monitoring.

Locally stored source content

Original GlobalRPh protocol

Clinical facts and comments transcribed into a structured reading format. This is not a byte-for-byte HTML archive. Original source: https://globalrph.com/renal/streptomycin/

Usual Dosing (Adults)

Tuberculosis daily therapy: 15 mg/kg/day IM, maximum 1 g. Twice-weekly directly observed therapy: 25-30 mg/kg IM, maximum 1.5 g. Three-times-weekly DOT: 25-30 mg/kg IM, maximum 1 g. Historical streptococcal endocarditis regimen: 1 g IM/IV every 12 hours for 7 days, then 500 mg every 12 hours for 1 week.

GRPH-streptomycin-01 · Source section: Usual Dosing (Adults)Renal section finder

Renal Dosing

CrCl above 50 mL/min: every 24 hours. 10-50: every 24-72 hours. Below 10: every 72-96 hours.

GRPH-streptomycin-02 · Source section: Renal DosingRenal section finder

Hemodialysis

Use the below-10 regimen; give after dialysis on dialysis days.

GRPH-streptomycin-03 · Source section: HemodialysisRenal section finder

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 0 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://globalrph.com/renal/streptomycin/
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
globalrph individual
Local text SHA-256
3f9209fd51be4358a511d6501ce0a3c0540021e8e1fab0e3e30bc868482f60b7
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

The original individual GlobalRPh pages commonly cite NIH/NLM DailyMed and instruct readers to review the applicable package insert for updates. That historical reference is preserved as context; it is not counted as an independently retrieved current label.

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