GlobalRPh Renal Dosing Masterv6.6
GlobalRPh source record

Sotalol

GlobalRPh source pageBase record retrieved 2026-09-05See the evidence for this drug1 sources available - open source summaries, references and comparisons
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Renal measure
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High-risk QT-active drug: the historical source is not a complete initiation/reinitiation, QT, electrolyte or monitored-titration protocol. Do not apply its nonspecific HD supplement automatically across indications/products.

Usual adult ventricular-arrhythmia dosing

Start 80 mg orally twice daily; increase gradually to 240-320 mg/day, allowing 3 days between increases. Most patients respond to 160-320 mg/day in 2-3 doses in the source.

Renal Dosing - ventricular arrhythmias

Betapace/Sorine source table, CrCl mL/min: above 60, every 12 hours; 30-60, every 24 hours; 10-30, every 36-48 hours; below 10, individualize.

Renal Dosing - atrial fibrillation/flutter

Betapace AF historical table: CrCl above 60, every 12 hours; 40-60, every 24 hours; below 40, contraindicated.

Dialysis comments

The source proposes giving after HD or an additional 80 mg dose. PD does not remove sotalol, so no PD supplement is described.

Source revision: Historical source; revision not established here | Retrieved: 2026-09-05. Retrieval date is not the revision date.

Source: https://globalrph.com/renal/sotalol/

Scope: Preserved historical source; no fresh clinical approval GlobalRPh v6.6.

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Preserved GlobalRPh source

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Renal method: Read the measure and population stated in the original source sections.
Retrieved: 2026-09-05

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Original content / product scope
Historical source content is not a current prescription. Original GlobalRPh recommendations are preserved, not automatically certified as current. Product-label and professional additions below are separately attributed. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.

Important source distinctions

High-risk QT-active drug: the historical source is not a complete initiation/reinitiation, QT, electrolyte or monitored-titration protocol. Do not apply its nonspecific HD supplement automatically across indications/products.

Locally stored source content

Original GlobalRPh protocol

Clinical facts and comments transcribed into a structured reading format. This is not a byte-for-byte HTML archive. Original source: https://globalrph.com/renal/sotalol/

Usual adult ventricular-arrhythmia dosing

Start 80 mg orally twice daily; increase gradually to 240-320 mg/day, allowing 3 days between increases. Most patients respond to 160-320 mg/day in 2-3 doses in the source.

GRPH-sotalol-01 · Source section: Usual adult ventricular-arrhythmia dosingRenal section finder

Renal Dosing - ventricular arrhythmias

Betapace/Sorine source table, CrCl mL/min: above 60, every 12 hours; 30-60, every 24 hours; 10-30, every 36-48 hours; below 10, individualize.

GRPH-sotalol-02 · Source section: Renal Dosing - ventricular arrhythmiasRenal section finder

Renal Dosing - atrial fibrillation/flutter

Betapace AF historical table: CrCl above 60, every 12 hours; 40-60, every 24 hours; below 40, contraindicated.

GRPH-sotalol-03 · Source section: Renal Dosing - atrial fibrillation/flutterRenal section finder

Dialysis comments

The source proposes giving after HD or an additional 80 mg dose. PD does not remove sotalol, so no PD supplement is described.

GRPH-sotalol-04 · Source section: Dialysis commentsRenal section finder

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 0 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://globalrph.com/renal/sotalol/
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
globalrph individual
Local text SHA-256
ac5573c5850ee2ac1f847998d0530e560784ff9b26bd6a94d8916b4336aca9c3
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

The original individual GlobalRPh pages commonly cite NIH/NLM DailyMed and instruct readers to review the applicable package insert for updates. That historical reference is preserved as context; it is not counted as an independently retrieved current label.

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