Sitagliptin / metformin extended-release (Janumet XR)

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Official source

Sitagliptin / metformin extended-release (Janumet XR) - selected U.S. label sections

Product / population: JANUMET XR extended-release combination tablets only.
Renal measure: eGFR in mL/min/1.73 m2

Selected renal sections only, not a complete monograph. Exact product, indication, patient population, renal method and all other contraindications/interactions remain controlling.

Second independent renal reference and clinician adjudication remain pending; no all-indication, dialysis or pediatric dose may be inferred from an omitted field.

Renal initiation and continuation

Below eGFR 30, JANUMET XR is contraindicated and must be discontinued. Initiation is not recommended between eGFR 30 and 45. If eGFR falls below 45 during treatment, reassess the benefit-risk balance and limit the sitagliptin component to 50 mg once daily.

Contrast precautions

At eGFR 30-60, stop at or before iodinated contrast; re-evaluate after 48 hours and restart only with stable renal function. Other label-based contrast exclusions also apply. Do not substitute the IR combination recommendation for the XR continuation rule.

Source revision: Revision not captured; retrieval date is not the revision date. | Retrieved: 2026-09-05. Retrieval date is not the revision date.

Source: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=64beb3d2-3aeb-4cd5-ba11-dacf6c9a5b50

Scope: Local label summary; independent clinical review pending. Not a two-source validated protocol. GlobalRPh v6.6.

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Official product label

Sitagliptin / metformin extended-release (Janumet XR) - selected U.S. label sections

JANUMET XR extended-release combination tablets only.

Renal method: eGFR in mL/min/1.73 m2
Retrieved: 2026-09-05

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New source summary - independent clinical review pending. Summaries of the identified label sections are included locally. Source import and numeric transcription checks are not independent two-reference validation. Do not treat this card as an approved institutional dosing protocol.

Official source

Sitagliptin / metformin extended-release (Janumet XR) - selected U.S. label sections

JANUMET XR extended-release combination tablets only.

Method: eGFR in mL/min/1.73 m2

Renal initiation and continuation Read this complete source summary

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Original content / product scope Sitagliptin / metformin extended-release (Janumet XR) - selected U.S. label sections

Exact product and population matter. This added page contains locally stored, source-specific clinical summaries. Historical handbook information, when present, is identified separately and may conflict with U.S. labeling. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.

Locally stored source content

Exact product and population

Product identity selected for the separately displayed source protocols below. Reference: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=64beb3d2-3aeb-4cd5-ba11-dacf6c9a5b50

Product and population scope

JANUMET XR extended-release combination tablets only.

RDM32-sitagliptin-metformin-janumet-xr-scope · Source section: Editorial scope for the selected U.S. labelRenal section finder

Separate U.S. product-label layer

FDA / DailyMed dosing and renal information

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Sitagliptin / metformin extended-release (Janumet XR) - selected U.S. label sections

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U.S. product labeling / DailyMed · JANUMET XR extended-release combination tablets only.

Renal method: eGFR in mL/min/1.73 m2
Source date: Revision not captured; retrieval date is not the revision date.
Retrieved: 2026-09-05

Local label summary; independent clinical review pending. Not a two-source validated protocol.

Renal initiation and continuation

RDM32-sitagliptin-metformin-janumet-xr-1 · Source locator: 2.2; 8.6

Contrast precautions

RDM32-sitagliptin-metformin-janumet-xr-2 · Source locator: 2.3; 5.1

Source-specific limits

Selected renal sections only, not a complete monograph. Exact product, indication, patient population, renal method and all other contraindications/interactions remain controlling.

Second independent renal reference and clinician adjudication remain pending; no all-indication, dialysis or pediatric dose may be inferred from an omitted field.

Source identity and provenance

Source: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=64beb3d2-3aeb-4cd5-ba11-dacf6c9a5b50
Retrieved: 2026-09-05
DailyMed Set ID: 64beb3d2-3aeb-4cd5-ba11-dacf6c9a5b50
Renal-function method: eGFR in mL/min/1.73 m2
Source date/version: Revision not captured; retrieval date is not the revision date.
Hash meaning: SHA-256 identifies this local summary, not original SPL XML or a label PDF.
Local summary SHA-256: 1bf40c9a2fd1f42bca523814005e9be8f1035279009641ce4973b86e90691a78

Provenance and preservation

Additional summaries stored on this page: 1 official-label, 0 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=64beb3d2-3aeb-4cd5-ba11-dacf6c9a5b50
Source retrieval: 2026-09-05. This is not the source publication or label revision date.
Original source type: multisource addition
Local text SHA-256: 907a176599f6170ee3f72619f78ef0d9b4dc6b37e2da2f6bd126ad326a641953
Import versus clinical validation: Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

This page is an additional exact-product entry, not a recovered GlobalRPh monograph. Its primary scope text and separately attributed clinical summaries are locally included.

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