GlobalRPh Renal Dosing Masterv6.6
GlobalRPh source record

Sitagliptin

Local RX List renal extractBase record retrieved 2026-09-05See the evidence for this drug3 sources available - open source summaries, references and comparisons

Januvia

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Renal guidance at a glance

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Display order is not a clinical ranking. Date of retrieval is not the label revision date. Sources are never merged into one regimen. Other sources and conflicts remain below.

Rxlist source

GlobalRPh RX List - JANUVIA

Product / population
Adult oral sitagliptin single-agent tablets; not JANUMET, JANUMET XR or JUVISYNC.
Renal measure
Indexed eGFR, mL/min/1.73 m2; source typography has displaced superscripts.

RX mirror: this is not independent corroboration of its underlying label. Check dated-label and formulation limitations.

Renal dosing, restrictions and evidence limits

The usual adult dose is 100 mg once daily. At eGFR 45 to below 90 mL/min/1.73 m2, no renal reduction is required; at 30 to below 45, use 50 mg once daily; below 30, including ESRD treated by hemodialysis or peritoneal dialysis, use 25 mg once daily. Administration does not need to be coordinated with dialysis. Assess kidney function before starting and periodically. This schedule is for single-agent sitagliptin, not a metformin-containing fixed combination. The mirrored page has misplaced superscripts; the named measure remains indexed eGFR.

Source revision: Source revision date not established in selected retrieval. | Retrieved: 2026-09-07. Retrieval date is not the revision date.

Source: https://globalrph.com/rx-list/januvia-drug/

Scope: Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph. GlobalRPh v6.6.

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Source-first renal review

Evidence sources and renal implications

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Preserved GlobalRPh source

Preserved original GlobalRPh source

Preserved historical content; not revalidated as current prescribing guidance.

Renal method: Read the measure and population stated in the original source sections.
Retrieved: 2026-09-05

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GlobalRPh RX List

GlobalRPh RX List - Zituvio

Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Oral sitagliptin; not a fixed combination.

Renal method: eGFR, mL/min/1.73 m2.
Retrieved: 2026-09-07

Read local renal resultOpen original reference
GlobalRPh RX List

GlobalRPh RX List - JANUVIA

Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Adult oral sitagliptin single-agent tablets; not JANUMET, JANUMET XR or JUVISYNC.

Renal method: Indexed eGFR, mL/min/1.73 m2; source typography has displaced superscripts.
Retrieved: 2026-09-07

Read local renal resultOpen original reference

Source presence is not independent validation. A label mirror is not a second independent source; review the original reference and exact formulation.

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Renal-context checklist: population, kidney trend and dialysis

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See source-specific renal methods and the clinical interpretation guide for the supporting context.

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Renal dosing and precautions

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New source summary - independent clinical review pending. Summaries of the identified label sections are included locally. Source import and numeric transcription checks are not independent two-reference validation. Do not treat this card as an approved institutional dosing protocol.

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Original content / product scopeGlobalRPh RX List - ZituvioGlobalRPh RX List - JANUVIA
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Historical source content is not a current prescription. Original GlobalRPh recommendations are preserved, not automatically certified as current. Product-label and professional additions below are separately attributed. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.

Important source distinctions

Historical CrCl-based cutoffs and approximate serum-creatinine correlates are not a current eGFR-based FDA-label table.

Locally stored source content

Original GlobalRPh protocol

Clinical facts and comments transcribed into a structured reading format. This is not a byte-for-byte HTML archive. Original source: https://globalrph.com/renal/sitagliptin/

Usual Dosing (Adults)

Adjunct to diet/exercise for adult type 2 diabetes: JANUVIA 100 mg once daily with or without food.

GRPH-sitagliptin-01 · Source section: Usual Dosing (Adults)Renal section finder

Original CrCl-based renal table

CrCl at least 50 mL/min: no adjustment. The source gives approximate serum-creatinine correlates at or below 1.7 mg/dL in men or 1.5 in women.

CrCl 30 to under 50: 50 mg daily; approximate source serum creatinine above 1.7 to 3 mg/dL in men or above 1.5 to 2.5 in women.

CrCl below 30 or ESRD receiving HD/PD: 25 mg daily; approximate source serum creatinine above 3 mg/dL in men or above 2.5 in women.

Assess renal function before starting and periodically. The source gives Cockcroft-Gault: (140 - age) x weight in kg / (72 x serum creatinine in mg/dL), multiplied by 0.85 for females.

GRPH-sitagliptin-02 · Source section: Original CrCl-based renal tableRenal section finder

Hemodialysis and peritoneal dialysis

25 mg once daily. Hemodialysis timing does not affect administration in the source.

GRPH-sitagliptin-03 · Source section: Hemodialysis and peritoneal dialysisRenal section finder
Locally imported selected renal sections

GlobalRPh RX List renal information

Rxlist

GlobalRPh RX List - Zituvio

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GlobalRPh-hosted RX List · Oral sitagliptin; not a fixed combination.

Renal method: eGFR, mL/min/1.73 m2.
Source date: Revised August 2024
Retrieved: 2026-09-07

Label mirror, not independent corroboration. This is selected locally stored RX List content. Full monograph import and current official-label review are not implied.
Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Locally imported selected source sections; independent clinical review pending. Not a complete prescribing monograph.

Renal dosing, restrictions and evidence limits

At eGFR at least 45 to less than 90, no renal dosage change is needed from the usual 100 mg once daily. At 30 to less than 45, use 50 mg once daily. Below 30, including hemodialysis or peritoneal dialysis, use 25 mg once daily without regard to dialysis timing. Assess renal function before treatment and periodically thereafter.

RDM33-rxlist-sitagliptin-C1 · Source locator: Recommendations for use in renal impairment.

Source identity and provenance
Source family
product_label_mirror
Source
https://globalrph.com/rx-list/zituvio-drug/
Retrieved
2026-09-07
Renal-function method
eGFR, mL/min/1.73 m2.
Source date/version
Revised August 2024
Hash meaning
SHA-256 of the local authored summary only; original HTML/PDF/SPL bytes are not bundled or hashed.
Local summary SHA-256
8e8d5088bde93a05a8bab422f3878ee72638737bf86f3dda2dfebc2458101085
Rxlist

GlobalRPh RX List - JANUVIA

Open original reference

Open / share this exact local source

GlobalRPh-hosted RX List · Adult oral sitagliptin single-agent tablets; not JANUMET, JANUMET XR or JUVISYNC.

Renal method: Indexed eGFR, mL/min/1.73 m2; source typography has displaced superscripts.
Source date: Source revision date not established in selected retrieval.
Retrieved: 2026-09-07

Label mirror, not independent corroboration. This is selected locally stored RX List content. Full monograph import and current official-label review are not implied.
Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.

Renal dosing, restrictions and evidence limits

The usual adult dose is 100 mg once daily. At eGFR 45 to below 90 mL/min/1.73 m2, no renal reduction is required; at 30 to below 45, use 50 mg once daily; below 30, including ESRD treated by hemodialysis or peritoneal dialysis, use 25 mg once daily. Administration does not need to be coordinated with dialysis. Assess kidney function before starting and periodically. This schedule is for single-agent sitagliptin, not a metformin-containing fixed combination. The mirrored page has misplaced superscripts; the named measure remains indexed eGFR.

RDM36-rxlist-sitagliptin-cdd0b29274-C1 · Source locator: Dosage: Recommended Dosing and Recommendations for Use in Renal Impairment.

Source identity and provenance
Source family
product_label_mirror
Source
https://globalrph.com/rx-list/januvia-drug/
Retrieved
2026-09-07
Renal-function method
Indexed eGFR, mL/min/1.73 m2; source typography has displaced superscripts.
Source date/version
Source revision date not established in selected retrieval.
Hash meaning
SHA-256 of local authored summary only; not original HTML, PDF or SPL bytes.
Local summary SHA-256
005675713c0bfdcbf02740f59dd0607b29f96731e794c9100555c61662c5efcb

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 2 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://globalrph.com/renal/sitagliptin/
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
globalrph individual
Local text SHA-256
8d1fe75cf2d11c9672d2faf89d69a97eb795115aee48610fb3b1eaf37eb00848
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

The original individual GlobalRPh pages commonly cite NIH/NLM DailyMed and instruct readers to review the applicable package insert for updates. That historical reference is preserved as context; it is not counted as an independently retrieved current label.

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