OZEMPIC: selected primary-label renal guidance and limits
What matters first
Product: Adult OZEMPIC subcutaneous injection for its labeled indications; not oral semaglutide or another semaglutide brand/regimen.
- Renal action / finding
- No renal dose adjustment recommended.
- Evidence or dialysis limit
- Kidney-failure PK evidence is not a modality-specific dialysis schedule.
- Monitoring / application
- Monitor kidney function with volume-depleting reactions, especially during initiation/escalation.
- Product / population
- Adult OZEMPIC subcutaneous injection for its labeled indications; not oral semaglutide or another semaglutide brand/regimen.
- Renal measure
- Qualitative renal categories including kidney failure; no new renal threshold
- Source revision
- Revision date not captured in selected review; retrieval date is not revision date.
- Retrieved
- 2026-11-07 (not the revision date)
Kidney-failure PK evidence is not a modality-specific dialysis schedule.
Selected renal section, not a complete prescribing monograph. A label and its mirror are not independent evidence.
Sections 8.6 and 5.6
No dose adjustment is recommended for renal impairment, including kidney failure in the supporting PK evidence. Monitor renal function when adverse reactions can cause volume depletion, especially during initiation or escalation. The no-adjustment statement does not eliminate dehydration-related AKI risk or establish interchangeable dosing across semaglutide products.
Source: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=adec4fd2-6858-4c99-91d4-531f5f2a2d79
