Use the renal measure and units named by this source. Confirm product, indication, age, stable versus changing kidney function, and exact dialysis modality. The selected summary is not a complete prescribing monograph. Renal method and dosing checklist
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Display order is not a clinical ranking. Date of retrieval is not the label revision date. Sources are never merged into one regimen. Other sources and conflicts remain below.
1 additional source qualifications - review before use
Routine four-hour HD or peritoneal dialysis requires no additional dose. Use the HIV product's renal table, not the HBV product regimen.
Before applying: Apply only to the stated formulation, indication and renal population.
Also check: Epivir - product and source limitations
Official source
Epivir - labeled renal guidance
Renal action and limits
Lamivudine (Epivir), oral HIV treatment; adults and adolescents at least 25 kg Creatinine clearance (CrCl), mL/min
Action or finding
For HIV treatment in adults and adolescents at least 25 kg, reduce lamivudine dosing below CrCl 50 mL/min. At 30-49 mL/min give 150 mg daily; lower bands have distinct first and maintenance doses.
Limits and monitoring
Routine four-hour HD or peritoneal dialysis requires no additional dose. Use the HIV product's renal table, not the HBV product regimen.
Before use
Apply only to the stated formulation, indication and renal population.
Lamivudine (Epivir), oral HIV treatment; adults and adolescents at least 25 kg
Renal measure
Creatinine clearance (CrCl), mL/min
Source revision
DailyMed SPL version 24, posted Sep 14, 2026
Retrieved
2026-11-07 (not the revision date)
Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.
Renal guidance: 2.3, Table 2
Limits that apply to these rows
Routine four-hour HD or peritoneal dialysis requires no additional dose. Use the HIV product's renal table, not the HBV product regimen.
HIV treatment for adults and adolescents at least 25 kg
CrCl (mL/min)
First dose
Maintenance
>=50
Standard regimen
150 mg twice daily or 300 mg daily
30-49
150 mg
150 mg daily
15-29
150 mg
100 mg daily
5-14
150 mg
50 mg daily
<5
50 mg
25 mg daily
Read the retained text before reformatting
For HIV treatment in adults and adolescents at least 25 kg, reduce lamivudine dosing below CrCl 50 mL/min. At 30-49 mL/min give 150 mg daily; lower bands have distinct first and maintenance doses. Routine four-hour HD or peritoneal dialysis requires no additional dose. Use the HIV product's renal table, not the HBV product regimen.
Source revision: DailyMed SPL version 24, posted Sep 14, 2026 | Retrieved: 2026-11-07. Retrieval date is not the revision date.
Choose a source to jump directly to its locally stored result. Qualitative precautions and evidence gaps remain visible even when no numerical clearance schedule is supplied.
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Before applying a renal protocol
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No patient-specific dose is calculated. Context choices only display reminders; they do not validate, hide or change any regimen.
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Source-by-source comparison
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Choose one or two sources above or use the source checkboxes below.
Renal-context checklist: population, kidney trend and dialysis
These prompts are a reading aid, not a prescription checklist or proof that all requirements have been met. No selections are stored or sent to a server.
Read the exact source scope, renal metric and date before selecting a row. No applicability assessment has been performed.
These are specific issues found during source review, not an automated judgment that one source is universally correct. A label mirror and its original label are not independent evidence.
Source scope / renal recommendation differences
Epivir - product and source limitations
Routine four-hour HD or peritoneal dialysis requires no additional dose. Use the HIV product's renal table, not the HBV product regimen.
How to use this: Apply only to the stated formulation, indication and renal population.
Choose a source, then jump to its renal or dialysis section. These links locate stored text; they do not merge regimens or certify that sources agree.
Independent clinical review is pending. These selected summaries are not an approved institutional dosing protocol. Confirm the exact product, the complete current source and local policy before use.
Official source
Epivir - labeled renal guidance
Lamivudine (Epivir), oral HIV treatment; adults and adolescents at least 25 kg
No dialysis or renal heading shown? Read the complete source summary. Absence of a heading is not evidence that dose adjustment is unnecessary.
Compare or copy source versions
All content below is stored locally. Read a whole source version; do not combine its dose with another source's interval, renal metric or dialysis assumptions.
Exact product and population matter. This added page contains locally stored, source-specific clinical summaries. Historical handbook information, when present, is identified separately and may conflict with U.S. labeling. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.
Routine four-hour HD or peritoneal dialysis requires no additional dose. Use the HIV product's renal table, not the HBV product regimen.
HIV treatment for adults and adolescents at least 25 kg
CrCl (mL/min)
First dose
Maintenance
>=50
Standard regimen
150 mg twice daily or 300 mg daily
30-49
150 mg
150 mg daily
15-29
150 mg
100 mg daily
5-14
150 mg
50 mg daily
<5
50 mg
25 mg daily
Read the retained text before reformatting
For HIV treatment in adults and adolescents at least 25 kg, reduce lamivudine dosing below CrCl 50 mL/min. At 30-49 mL/min give 150 mg daily; lower bands have distinct first and maintenance doses. Routine four-hour HD or peritoneal dialysis requires no additional dose. Use the HIV product's renal table, not the HBV product regimen.
GlobalRPh RX List / product-label mirror · Lamivudine (Epivir), oral HIV treatment; adults and adolescents at least 25 kg
Renal method: Use the renal measure explicitly present in the RX passage. Source date: Mirror revision not established in the reviewed passage. Retrieved: 2026-11-07
Label mirror, not independent corroboration. This is selected locally stored RX List content. Full monograph import and current official-label review are not implied.
Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.
For HIV treatment in adults and adolescents at least 25 kg, reduce lamivudine dosing below CrCl 50 mL/min. At 30-49 mL/min give 150 mg daily; lower bands have distinct first and maintenance doses.
Additional summaries stored on this page: 1 official-label, 1 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.
This page is an additional exact-product entry, not a recovered GlobalRPh monograph. Its primary scope text and separately attributed clinical summaries are locally included.
