GlobalRPh Renal Dosing Masterv6.6
GlobalRPh source record

Ritonavir

GlobalRPh source pageBase record retrieved 2026-09-05See the evidence for this drug1 sources available - open source summaries, references and comparisons

Norvir

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Renal measure
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Usual dosing and product-use comments

Take orally with other antiretrovirals, preferably with meals. Mild/moderate gastrointestinal symptoms and paresthesias may diminish during treatment.

Historical full-dose HIV treatment in adults: 600 mg twice daily. To improve tolerability, start no lower than 300 mg twice daily and increase by 100 mg twice daily every 2-3 days to a maximum 600 mg twice daily.

Pediatric patients older than 1 month: 350-400 mg/m2 twice daily, maximum 600 mg twice daily. Start 250 mg/m2 twice daily and increase by 50 mg/m2 twice daily every 2-3 days. When 400 mg/m2 is not tolerated, maintain the highest tolerated dose with other antiretrovirals but consider alternative therapy. The source recommends oral solution for children over 1 month unable to swallow capsules and refers its detailed administration to the full solution label.

Pharmacokinetic boosting distinction

Lower ritonavir doses are required with atazanavir, darunavir, fosamprenavir, saquinavir and tipranavir. Consult each companion protease-inhibitor label and clinical-study information; the full-treatment 600 mg twice-daily regimen is not a universal boosting dose.

Renal Dosing

No adjustment required.

Hemodialysis

Insufficient data; the source considers adjustment unlikely.

Source revision: Historical source; revision not established here | Retrieved: 2026-09-05. Retrieval date is not the revision date.

Source: https://globalrph.com/renal/ritonavir/

Scope: Preserved historical source; no fresh clinical approval GlobalRPh v6.6.

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Retrieved: 2026-09-05

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Locally stored source content

Original GlobalRPh protocol

Clinical facts and comments transcribed into a structured reading format. This is not a byte-for-byte HTML archive. Original source: https://globalrph.com/renal/ritonavir/

Usual dosing and product-use comments

Take orally with other antiretrovirals, preferably with meals. Mild/moderate gastrointestinal symptoms and paresthesias may diminish during treatment.

Historical full-dose HIV treatment in adults: 600 mg twice daily. To improve tolerability, start no lower than 300 mg twice daily and increase by 100 mg twice daily every 2-3 days to a maximum 600 mg twice daily.

Pediatric patients older than 1 month: 350-400 mg/m2 twice daily, maximum 600 mg twice daily. Start 250 mg/m2 twice daily and increase by 50 mg/m2 twice daily every 2-3 days. When 400 mg/m2 is not tolerated, maintain the highest tolerated dose with other antiretrovirals but consider alternative therapy. The source recommends oral solution for children over 1 month unable to swallow capsules and refers its detailed administration to the full solution label.

GRPH-ritonavir-01 · Source section: Usual dosing and product-use commentsRenal section finder

Pharmacokinetic boosting distinction

Lower ritonavir doses are required with atazanavir, darunavir, fosamprenavir, saquinavir and tipranavir. Consult each companion protease-inhibitor label and clinical-study information; the full-treatment 600 mg twice-daily regimen is not a universal boosting dose.

GRPH-ritonavir-02 · Source section: Pharmacokinetic boosting distinctionRenal section finder

Renal Dosing

No adjustment required.

GRPH-ritonavir-03 · Source section: Renal DosingRenal section finder

Hemodialysis

Insufficient data; the source considers adjustment unlikely.

GRPH-ritonavir-04 · Source section: HemodialysisRenal section finder

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 0 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://globalrph.com/renal/ritonavir/
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
globalrph individual
Local text SHA-256
ff49540f0c196c18df8a58d57a9a318ed194e0d3022e234100c948a3449f3610
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

The original individual GlobalRPh pages commonly cite NIH/NLM DailyMed and instruct readers to review the applicable package insert for updates. That historical reference is preserved as context; it is not counted as an independently retrieved current label.

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