GlobalRPh RX List - REVUFORJ
- Product / population
- Revumenib - REVUFORJ tablets; selected renal passages, not a complete prescribing monograph.
- Renal measure
- Creatinine clearance (CrCl), mL/min; equation not specified in the selected passage.
RX mirror: this is not independent corroboration of its underlying label. Check dated-label and formulation limitations.
Renal dosing, restrictions and evidence limits
No clinically significant exposure differences were found at CrCl 30-89 mL/min. Effects of severe impairment below 30 and ESRD below 15 are unknown. These PK findings are not a complete renal-dose algorithm or a dialysis regimen. Acute renal failure may occur with differentiation syndrome; renal deterioration during treatment therefore warrants assessment in the wider clinical context rather than an automatic dose reduction derived from this PK paragraph. Full regimen selection also depends on body size and interacting CYP3A drugs.