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Usual oral dose is 25 mg/kg daily, maximum 2000 mg/day. At CrCl <30 mL/min, use 25 mg/kg three times weekly. IHD uses that intermittent schedule after dialysis; no CRRT regimen is supplied. Stanford uses lean body weight for obesity.
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Preserved historical content; not revalidated as current prescribing guidance.
Adults; source-specific institutional guidance. Match route, indication and renal replacement modality.
Adults; combination TB treatment. Guide page 7.
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Read the exact source scope, renal metric and date before selecting a row. No applicability assessment has been performed.
Adults; source-specific institutional guidance. Match route, indication and renal replacement modality.
Adults; combination TB treatment. Guide page 7.
Preserved source. Not revalidated as current labeling.
All content below is stored locally. Read a whole source version; do not combine its dose with another source's interval, renal metric or dialysis assumptions.
The original summary, manufacturer discussion and dialysis advice are not mutually equivalent. Current tuberculosis/dialysis professional guidance must be reviewed separately.
15-30 mg/kg orally every 24 hours, maximum 2 g/day. Alternative intermittent regimen: 50 mg/kg twice weekly based on lean body weight, maximum 4 g on a dosing day.
The GlobalRPh summary states: CrCl above 50 mL/min, no change; below 50, avoid or reduce to 12-20 mg/kg/day. A separately quoted manufacturer position states that reduction does not appear required, although choosing the low end of the range may be prudent. Both positions are preserved.
The original GlobalRPh dialysis section says to avoid use.
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CrCl >30 mL/min: 20 mg/kg orally daily; below 30: 20 mg/kg three times weekly. The displayed bands do not assign exactly 30. Intermittent HD: 20 mg/kg initially and after HD. Continuous HD: 20 mg/kg daily.
Use adjusted body weight for BMI >30 kg/m2 and actual weight otherwise. Patients over 80 kg need ID pharmacy advice. The local approach follows SF public-health TB practice as of May 2025; other programs may use different weight-based schedules. This is one component of combination TB treatment.
RDM30-046-pyrazinamide-1 · Source locator: UCSF - pyrazinamide; renal/dosing sections and stated qualifiers
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Usual oral dose is 25 mg/kg daily, maximum 2000 mg/day. At CrCl <30 mL/min, use 25 mg/kg three times weekly. IHD uses that intermittent schedule after dialysis; no CRRT regimen is supplied. Stanford uses lean body weight for obesity.
RDM30-061-pyrazinamide-1 · Source locator: Stanford - pyrazinamide renal schedule; renal/dosing sections and stated qualifiers
The original individual GlobalRPh pages commonly cite NIH/NLM DailyMed and instruct readers to review the applicable package insert for updates. That historical reference is preserved as context; it is not counted as an independently retrieved current label.
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