GlobalRPh Renal Dosing Masterv6.6
GlobalRPh source record

Primidone

GlobalRPh source pageBase record retrieved 2026-09-05See the evidence for this drug1 sources available - open source summaries, references and comparisons
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Usual Dosing (Adults)

Seizure disorders: start 125-250 mg orally at bedtime; increase by 125-250 mg/day every 3-7 days. Usual 750-1,500 mg/day in 3-4 doses; maximum 2 g/day.

Renal Dosing

CrCl 50-80 mL/min: every 8 hours. 10-50: every 8-12 hours. Below 10: every 12-24 hours.

Hemodialysis

Dose as below CrCl 10; on dialysis days add one-third of the usual dose after dialysis.

Source revision: Historical source; revision not established here | Retrieved: 2026-09-05. Retrieval date is not the revision date.

Source: https://globalrph.com/renal/primidone/

Scope: Preserved historical source; no fresh clinical approval GlobalRPh v6.6.

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Retrieved: 2026-09-05

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Original content / product scope
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Locally stored source content

Original GlobalRPh protocol

Clinical facts and comments transcribed into a structured reading format. This is not a byte-for-byte HTML archive. Original source: https://globalrph.com/renal/primidone/

Usual Dosing (Adults)

Seizure disorders: start 125-250 mg orally at bedtime; increase by 125-250 mg/day every 3-7 days. Usual 750-1,500 mg/day in 3-4 doses; maximum 2 g/day.

GRPH-primidone-01 · Source section: Usual Dosing (Adults)Renal section finder

Renal Dosing

CrCl 50-80 mL/min: every 8 hours. 10-50: every 8-12 hours. Below 10: every 12-24 hours.

GRPH-primidone-02 · Source section: Renal DosingRenal section finder

Hemodialysis

Dose as below CrCl 10; on dialysis days add one-third of the usual dose after dialysis.

GRPH-primidone-03 · Source section: HemodialysisRenal section finder

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 0 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://globalrph.com/renal/primidone/
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
globalrph individual
Local text SHA-256
525efa2e4145ac29907c11e60b25a745f3fe42bb094418c5620249c8915f22c1
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

The original individual GlobalRPh pages commonly cite NIH/NLM DailyMed and instruct readers to review the applicable package insert for updates. That historical reference is preserved as context; it is not counted as an independently retrieved current label.

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