GlobalRPh RX List - ZEMDRI
- Product / population
- Adult IV plazomicin for complicated UTI; no extrapolated HD, CRRT or pediatric regimen.
- Renal measure
- Cockcroft-Gault CrCl, mL/min. Renal-estimation weight and mg/kg dosing weight differ.
RX mirror: this is not independent corroboration of its underlying label. Check dated-label and formulation limitations.
Renal dosing, restrictions and evidence limits
Adult cUTI, including pyelonephritis: initial IV doses over 30 minutes are 15 mg/kg every 24 hours at CrCl at least 60; 10 mg/kg every 24 hours at 30 to below 60; and 10 mg/kg every 48 hours at 15 to below 30 mL/min. The label uses Cockcroft-Gault with total body weight, switching to ideal body weight when total weight is at least 25% above ideal. Dose weight differs: use total weight, or adjusted weight = ideal + 0.4 x (total - ideal) at that same threshold. Check CrCl daily. For CrCl 15 to below 90, obtain a trough about 30 minutes before dose two; a trough at least 3 mcg/mL triggers a 1.5-fold interval extension (24 to 36 hours or 48 to 72 hours). Below CrCl 15 or during renal replacement therapy, evidence is insufficient for a regimen.