GlobalRPh RX List - PIVYA
- Product / population
- Pivmecillinam - PIVYA tablets; selected renal passages, not a complete prescribing monograph.
- Renal measure
- Qualitative renal statement; no numerical renal-function threshold inferred.
RX mirror: this is not independent corroboration of its underlying label. Check dated-label and formulation limitations.
Renal dosing, restrictions and evidence limits
Consider an alternative antibacterial in patients at risk of reduced serum carnitine, including significant renal impairment or reduced muscle mass. The warning supplies no numerical kidney-function cutoff. Avoid concomitant valproate/valproic acid or other pivalate-generating drugs because of carnitine depletion risk. Mecillinam elimination and urinary excretion decline with renal impairment, but that PK observation does not provide a numerical renal dose reduction. Do not mislabel this caution as either a specific CrCl contraindication or a blanket no-adjustment instruction.