The U.S. label uses CrCl in mL/min. eviQ protocol 3737 uses indexed eGFR and leaves exactly 30 outside its printed bands. Use the renal estimate specified by the selected source.
Before applying: Consult the exact cited section and other applicable sources before use.
Use the renal measure and units named by this source. Confirm product, indication, age, stable versus changing kidney function, and exact dialysis modality. The selected summary is not a complete prescribing monograph. Renal method and dosing checklist
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Display order is not a clinical ranking. Date of retrieval is not the label revision date. Sources are never merged into one regimen. Other sources and conflicts remain below.
For indexed eGFR 31-50, eviQ gives 200 mg orally twice daily and calls for toxicity monitoring. Above 50 it specifies no renal change. The table identifies limited evidence below 30 and leaves exactly 30 outside its printed bands. Use the protocol's renal measure and confirm borderline values.
Source revision: Online guidance checked 2026-11-07; section revision not established. | Retrieved: 2026-11-07. Retrieval date is not the revision date.
All sources, comparison tools and evidence navigation
Source-first renal review
Evidence sources and renal implications
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Renal-context checklist: population, kidney trend and dialysis
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Read the exact source scope, renal metric and date before selecting a row. No applicability assessment has been performed.
These are specific issues found during source review, not an automated judgment that one source is universally correct. A label mirror and its original label are not independent evidence.
Source scope / renal recommendation differences
Lynparza - product and source limitations
The U.S. label uses CrCl in mL/min. eviQ protocol 3737 uses indexed eGFR and leaves exactly 30 outside its printed bands. Use the renal estimate specified by the selected source.
How to use this: The U.S. label uses CrCl in mL/min. eviQ protocol 3737 uses indexed eGFR and leaves exactly 30 outside its printed bands. Use the renal estimate specified by the selected source.
Choose a source, then jump to its renal or dialysis section. These links locate stored text; they do not merge regimens or certify that sources agree.
Independent clinical review is pending. These selected summaries are not an approved institutional dosing protocol. Confirm the exact product, the complete current source and local policy before use.
Official source
Olaparib tablets (Lynparza) - selected U.S. label sections
LYNPARZA oral tablets, not the historical capsule formulation.
No dialysis or renal heading shown? Read the complete source summary. Absence of a heading is not evidence that dose adjustment is unnecessary.
Compare or copy source versions
All content below is stored locally. Read a whole source version; do not combine its dose with another source's interval, renal metric or dialysis assumptions.
Exact product and population matter. This added page contains locally stored, source-specific clinical summaries. Historical handbook information, when present, is identified separately and may conflict with U.S. labeling. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.
U.S. product labeling / DailyMed · LYNPARZA oral tablets, not the historical capsule formulation.
Renal method: Creatinine clearance in mL/min Source date: Revision not captured; retrieval date is not the revision date. Retrieved: 2026-09-05
Local label summary; independent clinical review pending. Not a two-source validated protocol.
Renal dose comments
CrCl 51-80 mL/min does not require a renal dose adjustment. At CrCl 31-50, reduce the tablet dose to 200 mg twice daily. Data are absent for severe impairment or end-stage disease with CrCl at or below 30.
Selected renal sections only, not a complete monograph. Exact product, indication, patient population, renal method and all other contraindications/interactions remain controlling.
Second independent renal reference and clinician adjudication remain pending; no all-indication, dialysis or pediatric dose may be inferred from an omitted field.
At CrCl 31-50 mL/min, use 200 mg twice daily. At 51-80, no renal dose change is recommended. The selected label has no data for CrCl <=30 mL/min, including end-stage disease. Check interaction-related modifications separately.
RDM73-lynparza-official-1 · Source locator: Renal guidance: 2.5 and 8.6
Renal method: Use the renal measure explicitly present in the RX passage. Source date: Mirror revision not established in the reviewed passage. Retrieved: 2026-11-07
Label mirror, not independent corroboration. This is selected locally stored RX List content. Full monograph import and current official-label review are not implied.
Pharmacokinetic observation only. A drug-exposure observation is not itself a dose recommendation.
For indexed eGFR 31-50, eviQ gives 200 mg orally twice daily and calls for toxicity monitoring. Above 50 it specifies no renal change. The table identifies limited evidence below 30 and leaves exactly 30 outside its printed bands. Use the protocol's renal measure and confirm borderline values.
Additional summaries stored on this page: 2 official-label, 1 RX List, 1 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.
This page is an additional exact-product entry, not a recovered GlobalRPh monograph. Its primary scope text and separately attributed clinical summaries are locally included.
