GlobalRPh RX List - KADIAN
- Product / population
- Oral extended-release morphine; renal initiation/titration guidance, not an opioid conversion algorithm.
- Renal measure
- Renal failure described qualitatively.
RX mirror: this is not independent corroboration of its underlying label. Check dated-label and formulation limitations.
Renal dosing, restrictions and evidence limits
Start with a lower-than-usual dose and titrate slowly in renal failure. Monitor sedation, respiratory depression and hypotension. Morphine glucuronide metabolites can accumulate. The source does not provide a numeric reduction percentage or a dialysis-specific schedule; do not invent one or treat this extended-release formulation as an as-needed opioid.