GlobalRPh Renal Dosing Masterv6.6
Evidence addition

Metoprolol tartrate immediate-release tablets

Local official-label summaryBase record retrieved 2026-09-05See the evidence for this drug2 sources available - open source summaries, references and comparisons

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Official source

Metoprolol tartrate immediate-release tablets - selected U.S. labeling

Product / population
Adults treated for hypertension with oral metoprolol tartrate immediate-release tablets. Excludes metoprolol succinate extended-release and intravenous acute-MI regimens.
Renal measure
Qualitative renal guidance; no CrCl dose-reduction table.
Labeled basic dosing

For hypertension, the selected label starts 100 mg/day in one or divided doses, with food or immediately after meals. Increase at weekly or longer intervals. The labeled effective range is 100-450 mg/day; doses above 450 mg/day were not studied.

Renal information and dialysis

No renal dose adjustment is required by the selected label. Systemic availability and half-life in renal failure do not differ meaningfully from normal renal function.

Selected warnings and limits

Follow blood pressure and pulse. Avoid abrupt withdrawal. Bradycardia, conduction disease, decompensated heart failure and interacting rate-slowing drugs affect individual suitability.

Source revision: Label revision date not separately recorded; retrieval date is not the revision date. | Retrieved: 2026-09-05. Retrieval date is not the revision date.

Source: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=991b445a-8cdc-4b99-bfd4-7da833f3f5c7

Scope: Selected dosing/renal sections read; concise local summary, not full prescribing information. GlobalRPh v6.6.

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Evidence sources and renal implications

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Official product label

Metoprolol tartrate immediate-release tablets - selected U.S. labeling

Adults treated for hypertension with oral metoprolol tartrate immediate-release tablets. Excludes metoprolol succinate extended-release and intravenous acute-MI regimens.

Renal method: Qualitative renal guidance; no CrCl dose-reduction table.
Retrieved: 2026-09-05

Read local renal resultOpen original reference
Handbook

Renal Drug Handbook, fifth edition - Metoprolol tartrate immediate-release tablets

Historical renal/RRT cross-check for the named ingredient; not a current U.S. prescribing instruction.

Renal method: Book table headings say GFR (mL/min); the preface states adjustment information is based on Cockcroft-Gault CrCl, not indexed eGFR. Do not substitute methods.
Retrieved: 2026-09-05

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Renal dosing and precautions

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Official source

Metoprolol tartrate immediate-release tablets - selected U.S. labeling

Adults treated for hypertension with oral metoprolol tartrate immediate-release tablets. Excludes metoprolol succinate extended-release and intravenous acute-MI regimens.

Method: Qualitative renal guidance; no CrCl dose-reduction table.

Renal information and dialysisRead this complete source summary
Handbook source

Renal Drug Handbook, fifth edition - Metoprolol tartrate immediate-release tablets

Historical renal/RRT cross-check for the named ingredient; not a current U.S. prescribing instruction.

Method: Book table headings say GFR (mL/min); the preface states adjustment information is based on Cockcroft-Gault CrCl, not indexed eGFR. Do not substitute methods.

Historical renal and dialysis observationsRead this complete source summary

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Original content / product scopeMetoprolol tartrate immediate-release tablets - selected U.S. labelingRenal Drug Handbook, fifth edition - Metoprolol tartrate immediate-release tablets
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Exact product and population matter. This added page contains locally stored, source-specific clinical summaries. Historical handbook information, when present, is identified separately and may conflict with U.S. labeling. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.
Locally stored source content

Exact product and population

Product identity selected for the separately displayed source protocols below. Reference: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=991b445a-8cdc-4b99-bfd4-7da833f3f5c7

Product and population scope

Adults treated for hypertension with oral metoprolol tartrate immediate-release tablets. Excludes metoprolol succinate extended-release and intravenous acute-MI regimens.

RDM31-metoprolol-tartrate-ir-scope · Source section: Editorial scope tied to selected U.S. labelRenal section finder
Separate U.S. product-label layer

FDA / DailyMed dosing and renal information

Official

Metoprolol tartrate immediate-release tablets - selected U.S. labeling

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U.S. product labeling / DailyMed · Adults treated for hypertension with oral metoprolol tartrate immediate-release tablets. Excludes metoprolol succinate extended-release and intravenous acute-MI regimens.

Renal method: Qualitative renal guidance; no CrCl dose-reduction table.
Source date: Label revision date not separately recorded; retrieval date is not the revision date.
Retrieved: 2026-09-05

Selected dosing/renal sections read; concise local summary, not full prescribing information.

Labeled basic dosing

For hypertension, the selected label starts 100 mg/day in one or divided doses, with food or immediately after meals. Increase at weekly or longer intervals. The labeled effective range is 100-450 mg/day; doses above 450 mg/day were not studied.

RDM31-metoprolol-tartrate-ir-label-dose · Source locator: Dosage and Administration: Hypertension

Renal information and dialysis

No renal dose adjustment is required by the selected label. Systemic availability and half-life in renal failure do not differ meaningfully from normal renal function.

RDM31-metoprolol-tartrate-ir-label-renal · Source locator: Dosage and Administration: Renal Impairment; Clinical Pharmacology

Selected warnings and limits

Follow blood pressure and pulse. Avoid abrupt withdrawal. Bradycardia, conduction disease, decompensated heart failure and interacting rate-slowing drugs affect individual suitability.

RDM31-metoprolol-tartrate-ir-label-limits · Source locator: Boxed warning; Contraindications; Warnings

Source identity and provenance
Source
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=991b445a-8cdc-4b99-bfd4-7da833f3f5c7
Retrieved
2026-09-05
DailyMed Set ID
991b445a-8cdc-4b99-bfd4-7da833f3f5c7
Renal-function method
Qualitative renal guidance; no CrCl dose-reduction table.
Source date/version
Label revision date not separately recorded; retrieval date is not the revision date.
Hash meaning
SHA-256 identifies this local summary, not original SPL XML or label PDF.
Local summary SHA-256
172f1a745a7b3798f5470f7abd76a08ec654043a1827141d261b475d55abdb65
Separate handbook layer

Renal Drug Handbook cross-check

Handbook

Renal Drug Handbook, fifth edition - Metoprolol tartrate immediate-release tablets

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UK Renal Pharmacy Group / CRC Press · Historical renal/RRT cross-check for the named ingredient; not a current U.S. prescribing instruction.

Renal method: Book table headings say GFR (mL/min); the preface states adjustment information is based on Cockcroft-Gault CrCl, not indexed eGFR. Do not substitute methods.
Source date: Fifth edition, 2019
Retrieved: 2026-09-05

Historical source, separately displayed. Renal tables were read with page-image inspection.

Historical renal and dialysis observations

The book retains ordinary dosing at 20-50 mL/min and advises a small starting dose with response-based titration at 10-20 and below 10. It distinguishes conventional HD/peritoneal therapy (not dialysed) from high-flux/HDF and continuous therapy (dialysed).

RDM31-metoprolol-tartrate-ir-book · Source locator: Dose in renal impairment; renal replacement therapies; Other information

Source-specific limits

Dialyzer-dependent historical statements must not be treated as interchangeable. The more conservative starting-dose advice is not a new labeled renal adjustment.

Source identity and provenance
Retrieved
2026-09-05
Handbook page
Printed page(s) 650-651; PDF page(s) 669,670
Renal-function method
Book table headings say GFR (mL/min); the preface states adjustment information is based on Cockcroft-Gault CrCl, not indexed eGFR. Do not substitute methods.
Source date/version
Fifth edition, 2019
U.S. product identity basis
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=991b445a-8cdc-4b99-bfd4-7da833f3f5c7
Hash meaning
SHA-256 identifies the local paraphrase; the source PDF is not redistributed.
Local summary SHA-256
96820f758ea2573752a5ae28e6581fc86969fb1464e83d093a9d511c492569f8

Provenance and preservation

Additional summaries stored on this page: 1 official-label, 0 RX List, 0 professional, 1 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=991b445a-8cdc-4b99-bfd4-7da833f3f5c7
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
multisource addition
Local text SHA-256
1a4b464d281e8145310cea379589ed1b66783083f3ee280784b475ecfa24aec8
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

This page is an additional exact-product entry, not a recovered GlobalRPh monograph. Its primary scope text and separately attributed clinical summaries are locally included.

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