GlobalRPh Renal Dosing Masterv6.6
GlobalRPh source record

Metoclopramide

GlobalRPh source pageBase record retrieved 2026-09-05See the evidence for this drug1 sources available - open source summaries, references and comparisons

Reglan

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Historical source

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Product / population
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Renal measure
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Historical source: not automatically current. Review current official labeling and separately attributed additions before use.

Historical dosing, EPS management and stability statements require current product- and indication-specific review. Label narrative and GlobalRPh below-10 table are distinct recommendations.

Usual dosing and administration

Diabetic gastroparesis: oral treatment may be initiated for early manifestations; severe symptoms may require IM/IV treatment initially. A 10 mg IV dose is administered slowly over 1-2 minutes. Injection treatment for up to 10 days may be needed before oral conversion.

Emetogenic chemotherapy: dilute doses over 10 mg in 50 mL. Infuse over at least 15 minutes, beginning 30 minutes before chemotherapy; repeat every 2 hours for two doses, then every 3 hours for three doses. The initial two doses are 2 mg/kg with highly emetogenic agents such as cisplatin or dacarbazine; 1 mg/kg per dose may suffice with less-emetogenic regimens. The source describes 50 mg IM diphenhydramine for extrapyramidal symptoms.

Postoperative nausea/vomiting prevention: 10 mg IM near the end of surgery; 20 mg may be used.

Small-bowel intubation after failure to pass the pylorus with conventional maneuvers for 10 minutes: a single undiluted IV dose over 1-2 minutes. Adults and children over 14 years: 10 mg base; age 6-14: 2.5-5 mg; under 6: 0.1 mg/kg. The same single doses are described for radiologic examinations impaired by delayed gastric emptying.

Original preparation and stability comments

Normal saline is the preferred diluent. The source permits freezing a saline admixture for up to 4 weeks but reports degradation when frozen in D5W. Dilutions in saline, D5W, D5/0.45% saline, Ringer's or lactated Ringer's may be stored for 48 hours without freezing when protected from light, or 24 hours under ordinary lighting without protection. These are historical product-specific stability statements, not a newly assigned sterile-compounding beyond-use date.

Renal Dosing

The source label discussion recommends initiating approximately half the usual dose below CrCl 40 mL/min and adjusting to clinical response/safety. Its GlobalRPh table lists: above 40, no change; 10-40, 50% of normal; below 10, 25% of normal.

Hemodialysis

Use the below-10 regimen. Only 0-5% is dialyzable in the source; no supplemental dose is necessary.

Source revision: Historical source; revision not established here | Retrieved: 2026-09-05. Retrieval date is not the revision date.

Source: https://globalrph.com/renal/metoclopramide/

Scope: Preserved historical source; no fresh clinical approval GlobalRPh v6.6.

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Preserved GlobalRPh source

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Retrieved: 2026-09-05

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Renal dosing and precautions

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Original content / product scope
Historical source content is not a current prescription. Original GlobalRPh recommendations are preserved, not automatically certified as current. Product-label and professional additions below are separately attributed. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.

Important source distinctions

Historical dosing, EPS management and stability statements require current product- and indication-specific review. Label narrative and GlobalRPh below-10 table are distinct recommendations.

Locally stored source content

Original GlobalRPh protocol

Clinical facts and comments transcribed into a structured reading format. This is not a byte-for-byte HTML archive. Original source: https://globalrph.com/renal/metoclopramide/

Usual dosing and administration

Diabetic gastroparesis: oral treatment may be initiated for early manifestations; severe symptoms may require IM/IV treatment initially. A 10 mg IV dose is administered slowly over 1-2 minutes. Injection treatment for up to 10 days may be needed before oral conversion.

Emetogenic chemotherapy: dilute doses over 10 mg in 50 mL. Infuse over at least 15 minutes, beginning 30 minutes before chemotherapy; repeat every 2 hours for two doses, then every 3 hours for three doses. The initial two doses are 2 mg/kg with highly emetogenic agents such as cisplatin or dacarbazine; 1 mg/kg per dose may suffice with less-emetogenic regimens. The source describes 50 mg IM diphenhydramine for extrapyramidal symptoms.

Postoperative nausea/vomiting prevention: 10 mg IM near the end of surgery; 20 mg may be used.

Small-bowel intubation after failure to pass the pylorus with conventional maneuvers for 10 minutes: a single undiluted IV dose over 1-2 minutes. Adults and children over 14 years: 10 mg base; age 6-14: 2.5-5 mg; under 6: 0.1 mg/kg. The same single doses are described for radiologic examinations impaired by delayed gastric emptying.

GRPH-metoclopramide-01 · Source section: Usual dosing and administrationRenal section finder

Original preparation and stability comments

Normal saline is the preferred diluent. The source permits freezing a saline admixture for up to 4 weeks but reports degradation when frozen in D5W. Dilutions in saline, D5W, D5/0.45% saline, Ringer's or lactated Ringer's may be stored for 48 hours without freezing when protected from light, or 24 hours under ordinary lighting without protection. These are historical product-specific stability statements, not a newly assigned sterile-compounding beyond-use date.

GRPH-metoclopramide-02 · Source section: Original preparation and stability commentsRenal section finder

Renal Dosing

The source label discussion recommends initiating approximately half the usual dose below CrCl 40 mL/min and adjusting to clinical response/safety. Its GlobalRPh table lists: above 40, no change; 10-40, 50% of normal; below 10, 25% of normal.

GRPH-metoclopramide-03 · Source section: Renal DosingRenal section finder

Hemodialysis

Use the below-10 regimen. Only 0-5% is dialyzable in the source; no supplemental dose is necessary.

GRPH-metoclopramide-04 · Source section: HemodialysisRenal section finder

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 0 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://globalrph.com/renal/metoclopramide/
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
globalrph individual
Local text SHA-256
12cfac2e0fbf8363f5e8bf25188faf579ee19b2cfee1dba5fa8cfa4d6aa09257
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

The original individual GlobalRPh pages commonly cite NIH/NLM DailyMed and instruct readers to review the applicable package insert for updates. That historical reference is preserved as context; it is not counted as an independently retrieved current label.

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