GlobalRPh Renal Dosing Masterv7.4
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Maraviroc (Selzentry)

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Local official-label summarySource retrieved 2026-09-05See the evidence for this drug3 sources available - open source summaries, references and comparisons

Selzentry / Maraviroc

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Renal guidance at a glance

Cautions / source differences (1)

Use the renal measure and units named by this source. Confirm product, indication, age, stable versus changing kidney function, and exact dialysis modality. The selected summary is not a complete prescribing monograph. Renal method and dosing checklist

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Display order is not a clinical ranking. Date of retrieval is not the label revision date. Sources are never merged into one regimen. Other sources and conflicts remain below.

1 additional source qualifications - review before use
Selzentry - product and source limitations

Consider use in this renal population only if alternatives are unavailable. Check concomitant drugs, age and orthostatic symptoms.

Before applying: Apply only to the stated formulation, indication and renal population.

Also check: Selzentry - product and source limitations

Official source

Selzentry - labeled renal guidance

Renal action and limits

Maraviroc (Selzentry), oral tablet
Creatinine clearance (CrCl), mL/min

Action or finding
At CrCl below 30 mL/min or in ESRD, potent CYP3A inhibitors or inducers contraindicate maraviroc. In adults without such interacting drugs, postural hypotension on 300 mg twice daily warrants reduction to 150 mg twice daily.
Limits and monitoring
Consider use in this renal population only if alternatives are unavailable. Check concomitant drugs, age and orthostatic symptoms.
Before use
Apply only to the stated formulation, indication and renal population.

DailyMed SPL version 26, posted Jun 24, 2026 | Selected sections checked 2026-11-07. Independent clinical review pending.

Choose a product and source Selzentry | GlobalRPh RX passage All evidence
Product / population
Maraviroc (Selzentry), oral tablet
Renal measure
Creatinine clearance (CrCl), mL/min
Source revision
DailyMed SPL version 26, posted Jun 24, 2026
Retrieved
2026-11-07 (not the revision date)
Restriction or avoidance guidance. Read the specific threshold, age, formulation and dialysis exclusions; do not generalize across products.

Renal guidance: 2.5 Recommended Dosage in Patients with Renal Impairment / 8.6 Renal Impairment

At CrCl below 30 mL/min or in ESRD, potent CYP3A inhibitors or inducers contraindicate maraviroc. In adults without such interacting drugs, postural hypotension on 300 mg twice daily warrants reduction to 150 mg twice daily. Consider use in this renal population only if alternatives are unavailable. Check concomitant drugs, age and orthostatic symptoms.

Source revision: DailyMed SPL version 26, posted Jun 24, 2026 | Retrieved: 2026-11-07. Retrieval date is not the revision date.

Source: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=46f30ac5-c96b-429e-976d-8c5ee1c0761b

Scope: Selected renal passages reviewed; independent clinician adjudication pending. GlobalRPh v7.4.

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Official

Selzentry - labeled renal guidance

Retrieved: 2026-11-07
Source revision: DailyMed SPL version 26, posted Jun 24, 2026

Renal measure: Creatinine clearance (CrCl), mL/min

Read this dated source finding
Rxlist

Selzentry - selected RX renal passage

Retrieved: 2026-11-07
Source revision: Mirror revision not established in the reviewed passage.

Renal measure: Use the renal measure explicitly present in the RX passage.

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Source-first renal review

Evidence sources and renal implications

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Read 1 source difference / applicability notes

Official product label

Selzentry - labeled renal guidance

Restriction or avoidance guidance. Read the specific threshold, age, formulation and dialysis exclusions; do not generalize across products.

Maraviroc (Selzentry), oral tablet

Renal method: Creatinine clearance (CrCl), mL/min
Retrieved: 2026-11-07

Read local renal resultOpen this source quick answerOpen original reference
GlobalRPh RX List

Selzentry - selected RX renal passage

Restriction or avoidance guidance. Read the specific threshold, age, formulation and dialysis exclusions; do not generalize across products.

Maraviroc (Selzentry), oral tablet

Renal method: Use the renal measure explicitly present in the RX passage.
Retrieved: 2026-11-07

Read local renal resultOpen this source quick answerOpen original reference

Source presence is not independent validation. A label mirror is not a second independent source; review the original reference and exact formulation.

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Source-specific review points

Selzentry - product and source limitations

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Source-quality holds
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Source differences and product cautions

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Source scope / renal recommendation differences

Selzentry - product and source limitations

Consider use in this renal population only if alternatives are unavailable. Check concomitant drugs, age and orthostatic symptoms.

How to use this: Apply only to the stated formulation, indication and renal population.

Selzentry - labeled renal guidanceSelzentry - selected RX renal passage

Selected renal passages reviewed; independent clinician adjudication pending.

Go directly to the relevant source section

Renal dosing and precautions

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Independent clinical review is pending. These selected summaries are not an approved institutional dosing protocol. Confirm the exact product, the complete current source and local policy before use.

No dialysis or renal heading shown? Read the complete source summary. Absence of a heading is not evidence that dose adjustment is unnecessary.

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Original content / product scopeSelzentry - labeled renal guidanceSelzentry - selected RX renal passage
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Historical source content is not a current prescription. Original GlobalRPh recommendations are preserved, not automatically certified as current. Product-label and professional additions below are separately attributed. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.
Locally stored source content

Original GlobalRPh protocol

Clinical facts and comments transcribed into a structured reading format. Read the original source for its complete context: https://globalrph.com/renal/maraviroc-selzentry/

Indication and tropism comments

SELZENTRY is used in combination for adult HIV-1 infection with only CCR5-tropic virus. The source describes two studies in treatment-experienced adults with three-class experience (NRTI, NNRTI, protease inhibitor and/or enfuvirtide) and ongoing replication, and one study in treatment-naive adults.

A highly sensitive validated tropism test is required. Outgrowth of previously undetected low-level CXCR4-tropic or dual/mixed virus can cause failure. The source reports no efficacy in a phase 2 study of dual/mixed or CXCR4 virus. It also describes unestablished pediatric use in that historical labeling and more virologic failure/lamivudine resistance in treatment-naive recipients than with efavirenz.

GRPH-maraviroc-selzentry-01 · Source section: Indication and tropism commentsRenal section finder

Usual Dosing (Adults)

Always combine with other antiretrovirals; take with or without food. Dose depends on coadministered drugs:

  • Potent CYP3A inhibitors, with or without an inducer: 150 mg twice daily. Examples include protease inhibitors except tipranavir/ritonavir, delavirdine, ketoconazole, itraconazole, clarithromycin, nefazodone and telithromycin.
  • Other drugs: 300 mg twice daily. Examples include tipranavir/ritonavir, nevirapine, raltegravir, NRTIs and enfuvirtide.
  • Potent CYP3A inducers without a potent inhibitor: 600 mg twice daily. Examples include efavirenz, rifampin, etravirine, carbamazepine, phenobarbital and phenytoin.
GRPH-maraviroc-selzentry-02 · Source section: Usual Dosing (Adults)Renal section finder

Renal Dosing and hemodialysis

For normal (CrCl above 80), mild (above 50 to 80) or moderate (30-50 mL/min) impairment: use the interaction-specific regimens above.

For severe impairment (CrCl below 30) and ESRD receiving hemodialysis:

  • With potent CYP3A inhibitors, with or without inducers: not recommended in the source table.
  • With drugs in the 'other' group: 300 mg twice daily; reduce to 150 mg twice daily if postural hypotension occurs.
  • With potent CYP3A inducers without an inhibitor: not recommended.

The separate hemodialysis heading supplies no additional instruction beyond this table.

GRPH-maraviroc-selzentry-03 · Source section: Renal Dosing and hemodialysisRenal section finder
Separate U.S. product-label layer

FDA / DailyMed dosing and renal information

Official

Selzentry - labeled renal guidance

Open original reference

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DailyMed / product prescribing information · Maraviroc (Selzentry), oral tablet

Renal method: Creatinine clearance (CrCl), mL/min
Source date: DailyMed SPL version 26, posted Jun 24, 2026
Retrieved: 2026-11-07

Restriction or avoidance guidance. Read the specific threshold, age, formulation and dialysis exclusions; do not generalize across products.

Selected renal passages reviewed; independent clinician adjudication pending.

Renal guidance: 2.5 Recommended Dosage in Patients with Renal Impairment / 8.6 Renal Impairment

At CrCl below 30 mL/min or in ESRD, potent CYP3A inhibitors or inducers contraindicate maraviroc. In adults without such interacting drugs, postural hypotension on 300 mg twice daily warrants reduction to 150 mg twice daily. Consider use in this renal population only if alternatives are unavailable. Check concomitant drugs, age and orthostatic symptoms.

RDM74-selzentry-official-1 · Source locator: Renal guidance: 2.5 Recommended Dosage in Patients with Renal Impairment / 8.6 Renal Impairment

Source identity and provenance
Source family
product_label
Source
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=46f30ac5-c96b-429e-976d-8c5ee1c0761b
Retrieved
2026-11-07
Renal-function method
Creatinine clearance (CrCl), mL/min
Source date/version
DailyMed SPL version 26, posted Jun 24, 2026
Hash meaning
SHA-256 of the local selected-source summary
Local summary SHA-256
f25e683c75c835c40c7c2ff80ae0e025185937db9d806041caf0c40675bf81d7
Locally imported selected renal sections

GlobalRPh RX List renal information

Rxlist

Selzentry - selected RX renal passage

Open original reference

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GlobalRPh RX List / product-label mirror · Maraviroc (Selzentry), oral tablet

Renal method: Use the renal measure explicitly present in the RX passage.
Source date: Mirror revision not established in the reviewed passage.
Retrieved: 2026-11-07

Label mirror, not independent corroboration. This is selected locally stored RX List content. Full monograph import and current official-label review are not implied.
Restriction or avoidance guidance. Read the specific threshold, age, formulation and dialysis exclusions; do not generalize across products.

Selected renal passages reviewed; independent clinician adjudication pending.

RX List: selected renal passage

At CrCl below 30 mL/min or in ESRD, potent CYP3A inhibitors or inducers contraindicate maraviroc. In adults without such interacting drugs, postural hypotension on 300 mg twice daily warrants reduction to 150 mg twice daily.

RDM74-selzentry-rxlist-1 · Source locator: RX List: selected renal passage

Source-specific limits

This mirror and the underlying product label share a source family.

Source identity and provenance
Source family
product_label_mirror
Source
https://globalrph.com/rx-list/selzentry-drug/
Retrieved
2026-11-07
Renal-function method
Use the renal measure explicitly present in the RX passage.
Source date/version
Mirror revision not established in the reviewed passage.
Hash meaning
SHA-256 of the local selected-source summary
Local summary SHA-256
3776f7e47322fa8e6232c4d9ed954ebbf30d09dd68c2dab56f3c254b590b4fa3

Provenance and preservation

Additional summaries stored on this page: 1 official-label, 1 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://globalrph.com/renal/maraviroc-selzentry/
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
globalrph individual
Local text SHA-256
dddec5fedae3a0fcd722be28136c95a605527a44990ba3bf697e2c40f226c8b1
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

The original individual GlobalRPh pages commonly cite NIH/NLM DailyMed and instruct readers to review the applicable package insert for updates. That historical reference is preserved as context; it is not counted as an independently retrieved current label.

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