Original GlobalRPh source
- Product / population
- Preserved GlobalRPh source, not a freshly verified product label
- Renal measure
- Use the method specified in the original source
Historical source: not automatically current. Review current official labeling and separately attributed additions before use.
Usual dosing source scope
The original usual-dosing section links to a separate magnesium-supplement guide rather than supplying a specific regimen. No numeric replacement dose is inferred from that link.
Renal Dosing
Magnesium is eliminated by the kidneys. Severe impairment (CrCl below 30 mL/min) requires lower doses and frequent serum-level monitoring in the GlobalRPh discussion. Use caution when replacing magnesium in any degree of renal insufficiency.
GlobalRPh physiological comments
Magnesium balance is regulated primarily by the kidneys; intake itself is not regulated. Dietary intake is approximately 20-30 mEq/day, with net absorption around 7 mEq/day. Normal urinary excretion equals net intake; during deficiency minimum urinary excretion is approximately 2 mEq/day.
About 30% of filtered magnesium is reabsorbed proximally and 65% in the thick ascending limb of Henle. Reabsorption is saturable: increased intake produces a proportionate increase in excretion. Consequently, hypermagnesemia is difficult to produce with normal renal function.
Hemodialysis
The source refers back to its preceding comments; no separate dialysis replacement regimen is supplied.