GlobalRPh Renal Dosing Masterv6.6
GlobalRPh source record

Lurasidone

GlobalRPh source pageBase record retrieved 2026-09-05See the evidence for this drug1 sources available - open source summaries, references and comparisons
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Historical source

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Renal measure
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Historical dose ceilings and approved-use descriptions are preserved, not asserted to be current FDA labeling.

Mechanism and historical indication context

The mechanism is unknown; central dopamine D2 and serotonin 5-HT2A antagonism is proposed. The source describes adult schizophrenia efficacy in four 6-week studies and states that efficacy beyond 6 weeks had not been established in that labeling context. Reevaluate patients receiving extended treatment.

Usual Dosing (Adults)

Start 40 mg once daily without initial titration. The historical source reports effectiveness from 40-120 mg/day, no additional benefit at 120 mg with more adverse reactions, and a maximum recommended dose of 80 mg/day. Take with food of at least 350 calories.

Renal and hepatic dosing

CrCl at least 10 but below 50 mL/min: maximum 40 mg/day in this historical source. After a single 40 mg dose, Cmax increased 40%, 92% and 54% in mild, moderate and severe impairment; AUC increased 53%, 91% and approximately 2-fold respectively.

Moderate/severe hepatic impairment: source maximum 40 mg/day.

Interaction comments

With a moderate CYP3A4 inhibitor such as diltiazem: source maximum 40 mg/day. Do not use with a strong CYP3A4 inhibitor such as ketoconazole or a strong inducer such as rifampin.

Hemodialysis

No additional hemodialysis recommendation was present under this heading in the retrieved source.

Source revision: Historical source; revision not established here | Retrieved: 2026-09-05. Retrieval date is not the revision date.

Source: https://globalrph.com/renal/lurasidone/

Scope: Preserved historical source; no fresh clinical approval GlobalRPh v6.6.

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Retrieved: 2026-09-05

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Original content / product scope
Historical source content is not a current prescription. Original GlobalRPh recommendations are preserved, not automatically certified as current. Product-label and professional additions below are separately attributed. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.

Important source distinctions

Historical dose ceilings and approved-use descriptions are preserved, not asserted to be current FDA labeling.

Locally stored source content

Original GlobalRPh protocol

Clinical facts and comments transcribed into a structured reading format. This is not a byte-for-byte HTML archive. Original source: https://globalrph.com/renal/lurasidone/

Mechanism and historical indication context

The mechanism is unknown; central dopamine D2 and serotonin 5-HT2A antagonism is proposed. The source describes adult schizophrenia efficacy in four 6-week studies and states that efficacy beyond 6 weeks had not been established in that labeling context. Reevaluate patients receiving extended treatment.

GRPH-lurasidone-01 · Source section: Mechanism and historical indication contextRenal section finder

Usual Dosing (Adults)

Start 40 mg once daily without initial titration. The historical source reports effectiveness from 40-120 mg/day, no additional benefit at 120 mg with more adverse reactions, and a maximum recommended dose of 80 mg/day. Take with food of at least 350 calories.

GRPH-lurasidone-02 · Source section: Usual Dosing (Adults)Renal section finder

Renal and hepatic dosing

CrCl at least 10 but below 50 mL/min: maximum 40 mg/day in this historical source. After a single 40 mg dose, Cmax increased 40%, 92% and 54% in mild, moderate and severe impairment; AUC increased 53%, 91% and approximately 2-fold respectively.

Moderate/severe hepatic impairment: source maximum 40 mg/day.

GRPH-lurasidone-03 · Source section: Renal and hepatic dosingRenal section finder

Interaction comments

With a moderate CYP3A4 inhibitor such as diltiazem: source maximum 40 mg/day. Do not use with a strong CYP3A4 inhibitor such as ketoconazole or a strong inducer such as rifampin.

GRPH-lurasidone-04 · Source section: Interaction commentsRenal section finder

Hemodialysis

No additional hemodialysis recommendation was present under this heading in the retrieved source.

GRPH-lurasidone-05 · Source section: HemodialysisRenal section finder

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 0 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://globalrph.com/renal/lurasidone/
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
globalrph individual
Local text SHA-256
08a4657dce5e70786b8f5d6aaf2f48d4ca3a1111d2f0db637ded71391c77e83d
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

The original individual GlobalRPh pages commonly cite NIH/NLM DailyMed and instruct readers to review the applicable package insert for updates. That historical reference is preserved as context; it is not counted as an independently retrieved current label.

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