GlobalRPh Renal Dosing Masterv6.6
Evidence addition

Losartan potassium - single agent

Local official-label summaryBase record retrieved 2026-09-05See the evidence for this drug2 sources available - open source summaries, references and comparisons
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Official source

Losartan single-agent tablets - adult renal precautions

Product / population
Adults; named product and route only. Selected dosing and renal summary, not the full prescribing information.
Renal measure
No renal-function dose bands specified for this summary.

Dosing / renal protocol and limits

Adult hypertension or diabetic nephropathy: usual starting dose 50 mg orally once daily; increase to 100 mg daily according to blood pressure response. A 25-mg start is recommended with possible intravascular depletion. Renal impairment alone does not require adjustment unless volume depletion is also present. Monitor creatinine and potassium and reassess volume status. The fetal-toxicity warning remains applicable. This adult single-agent statement does not apply to pediatric low-GFR use or a losartan/hydrochlorothiazide combination.

Source revision: DailyMed updated 2024-11-13. | Retrieved: 2026-09-05. Retrieval date is not the revision date.

Source: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=26cfdc1c-d017-ed31-e063-6394a90a54df

Scope: Locally included source-specific summary. Regimen differences are not automatically resolved. GlobalRPh v6.6.

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Official product label

Losartan single-agent tablets - adult renal precautions

Adults; named product and route only. Selected dosing and renal summary, not the full prescribing information.

Renal method: No renal-function dose bands specified for this summary.
Retrieved: 2026-09-05

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Handbook

Renal Drug Handbook, 5th edition - Losartan potassium

Historical adult renal/RRT summary. U.S. product identity anchored to the separate locally included DailyMed label. This is not a current U.S. product label.

Renal method: Book table headed GFR (mL/min); its preface states renal adjustments generally derive from Cockcroft-Gault CrCl. Do not silently relabel as indexed eGFR.
Retrieved: 2026-09-05

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Renal dosing and precautions

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Handbook source

Renal Drug Handbook, 5th edition - Losartan potassium

Historical adult renal/RRT summary. U.S. product identity anchored to the separate locally included DailyMed label. This is not a current U.S. product label.

Method: Book table headed GFR (mL/min); its preface states renal adjustments generally derive from Cockcroft-Gault CrCl. Do not silently relabel as indexed eGFR.

Historical renal / replacement-therapy guidanceRead this complete source summary

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Original content / product scopeLosartan single-agent tablets - adult renal precautionsRenal Drug Handbook, 5th edition - Losartan potassium
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Exact product and population matter. This added page contains locally stored, source-specific clinical summaries. Historical handbook information, when present, is identified separately and may conflict with U.S. labeling. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.
Locally stored source content

Exact product and population

Product identity selected for the separately displayed source protocols below. Reference: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=26cfdc1c-d017-ed31-e063-6394a90a54df

Product and population scope

Adult Losartan potassium - single agent. Use only the product, route, indication and renal-replacement setting explicitly stated in the source protocol selected below. Sources are alternatives to compare, not ingredients of a blended regimen.

SCOPE-losartan · Source section: Editorial scope; each clinical recommendation is separately attributed belowRenal section finder
Separate U.S. product-label layer

FDA / DailyMed dosing and renal information

Official

Losartan single-agent tablets - adult renal precautions

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NIH/NLM DailyMed - U.S. product labeling · Adults; named product and route only. Selected dosing and renal summary, not the full prescribing information.

Renal method: No renal-function dose bands specified for this summary.
Source date: DailyMed updated 2024-11-13.
Retrieved: 2026-09-05

Locally included source-specific summary. Regimen differences are not automatically resolved.

Dosing / renal protocol and limits

Adult hypertension or diabetic nephropathy: usual starting dose 50 mg orally once daily; increase to 100 mg daily according to blood pressure response. A 25-mg start is recommended with possible intravascular depletion. Renal impairment alone does not require adjustment unless volume depletion is also present. Monitor creatinine and potassium and reassess volume status. The fetal-toxicity warning remains applicable. This adult single-agent statement does not apply to pediatric low-GFR use or a losartan/hydrochlorothiazide combination.

RDM30-087-losartan-1 · Source locator: Losartan single-agent tablets - adult renal precautions; renal/dosing sections and stated qualifiers

Source identity and provenance
Source
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=26cfdc1c-d017-ed31-e063-6394a90a54df
Retrieved
2026-09-05
DailyMed Set ID
26cfdc1c-d017-ed31-e063-6394a90a54df
Renal-function method
No renal-function dose bands specified for this summary.
Source date/version
DailyMed updated 2024-11-13.
Hash meaning
Locally authored summary text; not original SPL, HTML or PDF bytes
Local summary SHA-256
ea158db05be7db750bb578ceb85cce5e7992e339fac26b92893b1d317bfc74e5
Separate handbook layer

Renal Drug Handbook cross-check

Handbook

Renal Drug Handbook, 5th edition - Losartan potassium

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UK Renal Pharmacy Group / CRC Press · Historical adult renal/RRT summary. U.S. product identity anchored to the separate locally included DailyMed label. This is not a current U.S. product label.

Renal method: Book table headed GFR (mL/min); its preface states renal adjustments generally derive from Cockcroft-Gault CrCl. Do not silently relabel as indexed eGFR.
Source date: 5th edition; 2019 copyright; historical reference
Retrieved: 2026-09-05

Historical handbook cross-check; not a current U.S. protocol

Historical renal / replacement-therapy guidance

At 20-50 mL/min, retain the usual indication dose. At 10-20 and <10, the book recommends an initial 25 mg dose and response-based titration. PD/HD/high-flux use the <10 band; continuous therapy uses 10-20; the drug is described as not dialyzed. This conservative low-function starting approach is distinct from the U.S. label, which ties lower starting doses especially to volume depletion. Monitor potassium and renal function.

HB30-losartan-1 · Source locator: Printed page 611: renal impairment, RRT and other information

Source-specific limits

Separate source recommendation, not proof of agreement or contemporary clinical validation. Dialysis predictions are retained with their original certainty.

Source identity and provenance
Retrieved
2026-09-05
Handbook page
5th edition, printed p. 611; uploaded PDF p. 630
Renal-function method
Book table headed GFR (mL/min); its preface states renal adjustments generally derive from Cockcroft-Gault CrCl. Do not silently relabel as indexed eGFR.
Source date/version
5th edition; 2019 copyright; historical reference
U.S. product identity basis
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=26cfdc1c-d017-ed31-e063-6394a90a54df
Hash meaning
Local paraphrase; original book not redistributed
Local summary SHA-256
5e16af2db65f36bfd5fd96082b089ec510fa7c2ab2fc42ab7a26f9ee22b9d37e

Provenance and preservation

Additional summaries stored on this page: 1 official-label, 0 RX List, 0 professional, 1 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=26cfdc1c-d017-ed31-e063-6394a90a54df
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
multisource addition
Local text SHA-256
e2c96f5eed895a163dcf4349735da70764da4a225717cfe4eaeac5e78a8ae9bd
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

This page is an additional exact-product entry, not a recovered GlobalRPh monograph. Its primary scope text and separately attributed clinical summaries are locally included.

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