GlobalRPh Renal Dosing Masterv6.6
Evidence addition

Lorlatinib - LORBRENA

Local RX List renal extractBase record retrieved 2026-09-08See the evidence for this drug1 sources available - open source summaries, references and comparisons

LORBRENA / Lorlatinib

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Rxlist source

GlobalRPh RX List - LORBRENA

Product / population
Lorlatinib - LORBRENA; selected renal source sections only, not a complete prescribing monograph.
Renal measure
Cockcroft-Gault creatinine clearance (CrCl), mL/min.

RX mirror: this is not independent corroboration of its underlying label. Check dated-label and formulation limitations.

Renal dosing, restrictions and evidence limits

At Cockcroft-Gault CrCl 15 to <30 mL/min, reduce LORBRENA from 100 mg to 75 mg orally once daily. No adjustment is recommended for CrCl 30-89 mL/min. ESRD requiring hemodialysis has not been studied. These renal instructions do not replace CYP3A interaction, hepatic, CNS or cardiac assessment, and no dose is invented for an unstudied dialysis population.

Source revision: Source revision date not established in selected retrieval. | Retrieved: 2026-09-08. Retrieval date is not the revision date.

Source: https://globalrph.com/rx-list/lorbrena-drug/

Scope: Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph. GlobalRPh v6.6.

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Evidence sources and renal implications

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GlobalRPh RX List

GlobalRPh RX List - LORBRENA

Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Lorlatinib - LORBRENA; selected renal source sections only, not a complete prescribing monograph.

Renal method: Cockcroft-Gault creatinine clearance (CrCl), mL/min.
Retrieved: 2026-09-08

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Renal dosing and precautions

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New source summary - independent clinical review pending. Summaries of the identified label sections are included locally. Source import and numeric transcription checks are not independent two-reference validation. Do not treat this card as an approved institutional dosing protocol.

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Original content / product scopeGlobalRPh RX List - LORBRENA
Exact product and population matter. This added page contains locally stored, source-specific clinical summaries. Historical handbook information, when present, is identified separately and may conflict with U.S. labeling. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.
Locally stored source content

Exact product and population

Product identity selected for the separately displayed source protocols below. Reference: https://globalrph.com/rx-list/lorbrena-drug/

Exact product and population

Lorlatinib - LORBRENA; selected renal source sections only, not a complete prescribing monograph.

RDM47-SCOPE-lorlatinib-lorbrena · Source section: Selected source product scopeRenal section finder
Locally imported selected renal sections

GlobalRPh RX List renal information

Rxlist

GlobalRPh RX List - LORBRENA

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GlobalRPh-hosted RX List · Lorlatinib - LORBRENA; selected renal source sections only, not a complete prescribing monograph.

Renal method: Cockcroft-Gault creatinine clearance (CrCl), mL/min.
Source date: Source revision date not established in selected retrieval.
Retrieved: 2026-09-08

Label mirror, not independent corroboration. This is selected locally stored RX List content. Full monograph import and current official-label review are not implied.
Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.

Renal dosing, restrictions and evidence limits

At Cockcroft-Gault CrCl 15 to <30 mL/min, reduce LORBRENA from 100 mg to 75 mg orally once daily. No adjustment is recommended for CrCl 30-89 mL/min. ESRD requiring hemodialysis has not been studied. These renal instructions do not replace CYP3A interaction, hepatic, CNS or cardiac assessment, and no dose is invented for an unstudied dialysis population.

RDM47-rxlist-lorlatinib-lorbrena-756bcb3554-C1 · Source locator: Dosage: severe renal impairment, lines 102-104; renal population and pharmacokinetics 502-557.

Source identity and provenance
Source family
product_label_mirror
Source
https://globalrph.com/rx-list/lorbrena-drug/
Retrieved
2026-09-08
Renal-function method
Cockcroft-Gault creatinine clearance (CrCl), mL/min.
Source date/version
Source revision date not established in selected retrieval.
Hash meaning
SHA-256 of local authored summary only; not original HTML, PDF or SPL bytes.
Local summary SHA-256
68a2fb837d42d9827281f962073f08d86d68a48000c852e1f1f54501878c133f

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 1 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://globalrph.com/rx-list/lorbrena-drug/
Source retrieval
2026-09-08. This is not the source publication or label revision date.
Original source type
rxlist summary
Local text SHA-256
1e159dd9b4456dfe0b7a9248b1682df0cf1d9ccbc051d1815d90c4c806135d3b
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

This page is an additional exact-product entry, not a recovered GlobalRPh monograph. Its primary scope text and separately attributed clinical summaries are locally included.

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