Lopinavir/ritonavir tablets (KALETRA) | GlobalRPh Renal Dosing Master

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The renal percentage reduction belongs to clarithromycin

The source includes CrCl-dependent clarithromycin reductions within KALETRA interaction guidance; its own renal PK statement is a separate observation.

Before applying: Identify which coadministered drug is being adjusted. Do not reduce KALETRA by the clarithromycin percentages.

Also check: The renal percentage reduction belongs to clarithromycin

Rxlist source

GlobalRPh RX List - KALETRA tablets

Product / population: Oral KALETRA tablets; renal pharmacokinetics and separate clarithromycin interaction.
Renal measure: CrCl mL/min only for the coadministered clarithromycin adjustment.

RX mirror: this is not independent corroboration of its underlying label. Check dated-label and formulation limitations.

Renal dosing, restrictions and evidence limits

KALETRA renal-impairment pharmacokinetics have not been studied; negligible renal clearance suggests no important reduction in total clearance. This is not a tested dialysis regimen. Separately, with coadministered clarithromycin, the source reduces the clarithromycin dose by 50% at CrCl 30-60 and by 75% below 30. Those percentages modify clarithromycin, not the KALETRA tablet dose.

Source revision: Source revision date not established in selected retrieval. | Retrieved: 2026-09-07. Retrieval date is not the revision date.

Source: https://globalrph.com/rx-list/kaletra-tablets-drug/

Scope: Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph. GlobalRPh v6.6.

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GlobalRPh RX List

GlobalRPh RX List - KALETRA tablets

Pharmacokinetic observation only. A drug-exposure observation is not itself a dose recommendation.

Oral KALETRA tablets; renal pharmacokinetics and separate clarithromycin interaction.

Renal method: CrCl mL/min only for the coadministered clarithromycin adjustment.
Retrieved: 2026-09-07

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interaction scope

The renal percentage reduction belongs to clarithromycin

The source includes CrCl-dependent clarithromycin reductions within KALETRA interaction guidance; its own renal PK statement is a separate observation.

How to use this: Identify which coadministered drug is being adjusted. Do not reduce KALETRA by the clarithromycin percentages.

GlobalRPh RX List - KALETRA tablets

Source-specific interpretation; independent clinician adjudication pending.

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Renal dosing and precautions

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Rxlist source

GlobalRPh RX List - KALETRA tablets

Oral KALETRA tablets; renal pharmacokinetics and separate clarithromycin interaction.

Method: CrCl mL/min only for the coadministered clarithromycin adjustment.

Renal dosing, restrictions and evidence limits Read this complete source summary

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Original content / product scope GlobalRPh RX List - KALETRA tablets

Exact product and population matter. This added page contains locally stored, source-specific clinical summaries. Historical handbook information, when present, is identified separately and may conflict with U.S. labeling. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.

Locally stored source content

Exact product and population

Product identity selected for the separately displayed source protocols below. Reference: https://globalrph.com/rx-list/kaletra-tablets-drug/

Exact product and population

Oral KALETRA tablets; renal pharmacokinetics and separate clarithromycin interaction.

RDM42-SCOPE-lopinavir-ritonavir-kaletra-tablets · Source section: Selected source product scopeRenal section finder

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GlobalRPh RX List - KALETRA tablets

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GlobalRPh-hosted RX List · Oral KALETRA tablets; renal pharmacokinetics and separate clarithromycin interaction.

Renal method: CrCl mL/min only for the coadministered clarithromycin adjustment.
Source date: Source revision date not established in selected retrieval.
Retrieved: 2026-09-07

Label mirror, not independent corroboration. This is selected locally stored RX List content. Full monograph import and current official-label review are not implied.

Pharmacokinetic observation only. A drug-exposure observation is not itself a dose recommendation.

Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.

Renal dosing, restrictions and evidence limits

RDM42-rxlist-lopinavir-ritonavir-kaletra-tablets-15f2dcc4b3-C1 · Source locator: Renal Impairment; Drug Interactions / clarithromycin

Source identity and provenance

Source family: product_label_mirror
Source: https://globalrph.com/rx-list/kaletra-tablets-drug/
Retrieved: 2026-09-07
Renal-function method: CrCl mL/min only for the coadministered clarithromycin adjustment.
Source date/version: Source revision date not established in selected retrieval.
Hash meaning: SHA-256 of local authored summary only; not original HTML, PDF or SPL bytes.
Local summary SHA-256: 8ac879fbd70ad0bbb6224f49e00849a51fc0fff33c8ec0a9006971df66a2184c

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 1 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source: https://globalrph.com/rx-list/kaletra-tablets-drug/
Source retrieval: 2026-09-07. This is not the source publication or label revision date.
Original source type: rxlist summary
Local text SHA-256: c08bacde8ed880dffc9b82b2ae35364651db69c7d631b4b26a338a9db0dcc876
Import versus clinical validation: Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

This page is an additional exact-product entry, not a recovered GlobalRPh monograph. Its primary scope text and separately attributed clinical summaries are locally included.

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