GlobalRPh Renal Dosing Masterv6.6
GlobalRPh source record

Lepirudin

GlobalRPh source pageBase record retrieved 2026-09-05See the evidence for this drug1 sources available - open source summaries, references and comparisons
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Usual Dosing (Adults)

Heparin-induced thrombocytopenia: 0.4 mg/kg IV push over 15 to 20 seconds, then 0.15 mg/kg/hour continuous infusion. Reduce both load/infusion in renal insufficiency. Do not exceed 0.21 mg/kg/hour. Maximum initial bolus 44 mg and initial infusion 16.5 mg/hour.

Renal Dosing

CrCl >60 mL/min: no changes. CrCl 45 to 60 or serum creatinine 1.6 to 2 mg/dL: 0.2 mg/kg IV over 15 to 20 seconds, then 50% usual infusion, 0.075 mg/kg/hour. CrCl 30 to 44 or creatinine 2.1 to 3: same 0.2 mg/kg load, then 30% infusion, 0.045 mg/kg/hour. CrCl 15 to 29 or creatinine 3.1 to 6: same 0.2 mg/kg load, then 15% infusion, 0.0225 mg/kg/hour. CrCl <15 or creatinine >6: avoid or STOP infusion.

Hemodialysis

Avoid use.

Source revision: Historical source; revision not established here | Retrieved: 2026-09-05. Retrieval date is not the revision date.

Source: https://globalrph.com/renal/lepirudin/

Scope: Preserved historical source; no fresh clinical approval GlobalRPh v6.6.

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Retrieved: 2026-09-05

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Original content / product scope
Historical source content is not a current prescription. Original GlobalRPh recommendations are preserved, not automatically certified as current. Product-label and professional additions below are separately attributed. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.
Locally stored source content

Original GlobalRPh protocol

Clinical facts and comments transcribed into a structured reading format. This is not a byte-for-byte HTML archive. Original source: https://globalrph.com/renal/lepirudin/

Usual Dosing (Adults)

Heparin-induced thrombocytopenia: 0.4 mg/kg IV push over 15 to 20 seconds, then 0.15 mg/kg/hour continuous infusion. Reduce both load/infusion in renal insufficiency. Do not exceed 0.21 mg/kg/hour. Maximum initial bolus 44 mg and initial infusion 16.5 mg/hour.

GRPH-lepirudin-01 · Source section: Usual Dosing (Adults)Renal section finder

Renal Dosing

CrCl >60 mL/min: no changes. CrCl 45 to 60 or serum creatinine 1.6 to 2 mg/dL: 0.2 mg/kg IV over 15 to 20 seconds, then 50% usual infusion, 0.075 mg/kg/hour. CrCl 30 to 44 or creatinine 2.1 to 3: same 0.2 mg/kg load, then 30% infusion, 0.045 mg/kg/hour. CrCl 15 to 29 or creatinine 3.1 to 6: same 0.2 mg/kg load, then 15% infusion, 0.0225 mg/kg/hour. CrCl <15 or creatinine >6: avoid or STOP infusion.

GRPH-lepirudin-02 · Source section: Renal DosingRenal section finder

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 0 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://globalrph.com/renal/lepirudin/
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
globalrph individual
Local text SHA-256
b09ba01835011d3a1678ebb6e8047e7b2743b8312199e95cdf9d1e1550269d7f
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

The original individual GlobalRPh pages commonly cite NIH/NLM DailyMed and instruct readers to review the applicable package insert for updates. That historical reference is preserved as context; it is not counted as an independently retrieved current label.

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