Lenalidomide capsules (indication-specific adult renal table) - selected U.S. label sections
- Product / population
- Selected U.S. lenalidomide capsule label. MM=myeloma; MCL=mantle-cell lymphoma; FL=follicular lymphoma; MZL=marginal-zone lymphoma; MDS=myelodysplastic syndromes.
- Renal measure
- Cockcroft-Gault creatinine clearance in mL/min
Selected renal sections only, not a complete monograph. Exact product, indication, patient population, renal method and all other contraindications/interactions remain controlling.
Second independent renal reference and clinician adjudication remain pending; no all-indication, dialysis or pediatric dose may be inferred from an omitted field.
Renal dose table - keep the indication-specific cycle
| CrCl | MM/MCL combination | FL/MZL combination | MM post-transplant maintenance or MDS |
|---|---|---|---|
| 30-60 mL/min | 10 mg once daily | 10 mg once daily | 5 mg once daily |
| Below 30, without dialysis | 15 mg every other day | 5 mg once daily | 2.5 mg once daily |
| Below 30, requiring dialysis | 5 mg once daily | 5 mg once daily | 2.5 mg once daily |
On dialysis days, administer after dialysis. Apply these doses within the indicated treatment cycle, not an invented continuous schedule.
Subsequent adjustment
For MM combination therapy at CrCl 30-60, the label permits considering 15 mg after two cycles if 10 mg was tolerated without dose-limiting toxicity. Subsequent changes depend on indication and tolerability.
Source: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2166bbdf-eb12-4564-b9e4-b63ca21312bc