GlobalRPh Renal Dosing Masterv6.6
GlobalRPh source record

Ketorolac

GlobalRPh source pageBase record retrieved 2026-09-05See the evidence for this drug1 sources available - open source summaries, references and comparisons

Toradol

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Usual Dosing (Adults)

Combined adult injection plus tablet duration must not exceed 5 days. Oral tablets are only continuation after injection. Used for moderately severe acute pain requiring opioid-level analgesia, usually postoperative. Correct hypovolemia first and switch to other analgesics as soon as possible.

IV bolus over at least 15 seconds; IM slowly/deeply. Onset about 30 minutes, peak 1 to 2 hours, usual duration 4 to 6 hours.

Single IM dose: <65 years, 60 mg; age >=65, renal impairment and/or weight <50 kg, 30 mg.

Single IV dose: <65 years, 30 mg; age >=65, renal impairment and/or weight <50 kg, 15 mg.

Multiple IV/IM dosing: <65 years, 30 mg every 6 hours, maximum 120 mg/day. Age >=65, renal impairment or weight <50 kg: 15 mg every 6 hours, maximum 60 mg/day. Do not increase dose/frequency for breakthrough pain; consider low-dose opioid supplementation when not contraindicated.

Renal Dosing

Contraindicated in advanced renal impairment and in risk of renal failure from volume depletion. Ketorolac/metabolites are primarily renally cleared, with diminished clearance when CrCl falls. Use cautiously and follow closely in impaired function. Acute renal failure, nephritis and nephrotic syndrome have been reported; weigh risks/benefits in pre-existing insufficiency. In moderately elevated serum creatinine, halve the injection daily dose, not exceeding 60 mg/day. Contraindicated when creatinine indicates advanced impairment. Correct hypovolemia before initiation.

Hemodialysis

Specific guidelines not available.

Source revision: Historical source; revision not established here | Retrieved: 2026-09-05. Retrieval date is not the revision date.

Source: https://globalrph.com/renal/ketorolac/

Scope: Preserved historical source; no fresh clinical approval GlobalRPh v6.6.

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Retrieved: 2026-09-05

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Locally stored source content

Original GlobalRPh protocol

Clinical facts and comments transcribed into a structured reading format. This is not a byte-for-byte HTML archive. Original source: https://globalrph.com/renal/ketorolac/

Usual Dosing (Adults)

Combined adult injection plus tablet duration must not exceed 5 days. Oral tablets are only continuation after injection. Used for moderately severe acute pain requiring opioid-level analgesia, usually postoperative. Correct hypovolemia first and switch to other analgesics as soon as possible.

IV bolus over at least 15 seconds; IM slowly/deeply. Onset about 30 minutes, peak 1 to 2 hours, usual duration 4 to 6 hours.

Single IM dose: <65 years, 60 mg; age >=65, renal impairment and/or weight <50 kg, 30 mg.

Single IV dose: <65 years, 30 mg; age >=65, renal impairment and/or weight <50 kg, 15 mg.

Multiple IV/IM dosing: <65 years, 30 mg every 6 hours, maximum 120 mg/day. Age >=65, renal impairment or weight <50 kg: 15 mg every 6 hours, maximum 60 mg/day. Do not increase dose/frequency for breakthrough pain; consider low-dose opioid supplementation when not contraindicated.

GRPH-ketorolac-01 · Source section: Usual Dosing (Adults)Renal section finder

Renal Dosing

Contraindicated in advanced renal impairment and in risk of renal failure from volume depletion. Ketorolac/metabolites are primarily renally cleared, with diminished clearance when CrCl falls. Use cautiously and follow closely in impaired function. Acute renal failure, nephritis and nephrotic syndrome have been reported; weigh risks/benefits in pre-existing insufficiency. In moderately elevated serum creatinine, halve the injection daily dose, not exceeding 60 mg/day. Contraindicated when creatinine indicates advanced impairment. Correct hypovolemia before initiation.

GRPH-ketorolac-02 · Source section: Renal DosingRenal section finder

Hemodialysis

Specific guidelines not available.

GRPH-ketorolac-03 · Source section: HemodialysisRenal section finder

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 0 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://globalrph.com/renal/ketorolac/
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
globalrph individual
Local text SHA-256
9e4d7e5c27c9dc30cd2cc18756e7409112feee59134b300cde2bc234be896e48
Import versus clinical validation
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The original individual GlobalRPh pages commonly cite NIH/NLM DailyMed and instruct readers to review the applicable package insert for updates. That historical reference is preserved as context; it is not counted as an independently retrieved current label.

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