GlobalRPh Renal Dosing Masterv6.6
Evidence addition

Isavuconazonium sulfate (Cresemba)

Local official-label summaryBase record retrieved 2026-09-05See the evidence for this drug4 sources available - open source summaries, references and comparisons

Cresemba / Isavuconazole

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Official source

DailyMed CRESEMBA renal-impairment statement

Product / population
CRESEMBA isavuconazonium sulfate capsules/injection; selected renal eligibility statement, not age/weight-specific complete dosing.
Renal measure
Renal-impairment categories; indexed eGFR in trial description.

Renal dosing, restrictions and evidence limits

No dose adjustment is needed for mild, moderate or severe renal impairment, including ESRD. The clinical-trial description includes patients with eGFR below 60 mL/min/1.73 m2. This selected renal statement does not replace formulation-, age- and weight-specific dosing, interaction review or hepatic monitoring. No additional dialysis removal or post-HD supplement claim is inferred from the excerpt.

Source revision: Source revision date not established in selected retrieval. | Retrieved: 2026-09-07. Retrieval date is not the revision date.

Source: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8f7f73b8-586a-4df0-935f-fecd4696c16c

Scope: Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph. GlobalRPh v6.6.

Full source card / provenance

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Source-first renal review

Evidence sources and renal implications

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Official product label

CRESEMBA - adult prodrug dose and renal statement

Adults; named product and route only. Selected dosing and renal summary, not the full prescribing information.

Renal method: No renal-function dose bands specified for this summary.
Retrieved: 2026-09-05

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Official product label

DailyMed CRESEMBA renal-impairment statement

Qualified no-adjustment statement. Apply only to the population, product and renal range described in this source.

CRESEMBA isavuconazonium sulfate capsules/injection; selected renal eligibility statement, not age/weight-specific complete dosing.

Renal method: Renal-impairment categories; indexed eGFR in trial description.
Retrieved: 2026-09-07

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Professional guidance

UCSF - isavuconazonium: dosing units and dialysis

Adults; source-specific institutional guidance. Match route, indication and renal replacement modality.

Renal method: Qualitative no-adjustment guidance.
Retrieved: 2026-09-05

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Handbook

Renal Drug Handbook, 5th edition - Isavuconazole (administered as isavuconazonium sulfate)

Historical adult renal/RRT summary. U.S. product identity anchored to the separate locally included DailyMed label. This is not a current U.S. product label.

Renal method: Book table headed GFR (mL/min); its preface states renal adjustments generally derive from Cockcroft-Gault CrCl. Do not silently relabel as indexed eGFR.
Retrieved: 2026-09-05

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Source presence is not independent validation. A label mirror is not a second independent source; review the original reference and exact formulation.

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Renal-context checklist: population, kidney trend and dialysis

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Renal dosing and precautions

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Handbook source

Renal Drug Handbook, 5th edition - Isavuconazole (administered as isavuconazonium sulfate)

Historical adult renal/RRT summary. U.S. product identity anchored to the separate locally included DailyMed label. This is not a current U.S. product label.

Method: Book table headed GFR (mL/min); its preface states renal adjustments generally derive from Cockcroft-Gault CrCl. Do not silently relabel as indexed eGFR.

Historical renal / replacement-therapy guidanceRead this complete source summary

No dialysis or renal heading shown? Read the complete source summary. Absence of a heading is not evidence that dose adjustment is unnecessary.

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Original content / product scopeCRESEMBA - adult prodrug dose and renal statementDailyMed CRESEMBA renal-impairment statementUCSF - isavuconazonium: dosing units and dialysisRenal Drug Handbook, 5th edition - Isavuconazole (administered as isavuconazonium sulfate)
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Exact product and population matter. This added page contains locally stored, source-specific clinical summaries. Historical handbook information, when present, is identified separately and may conflict with U.S. labeling. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.
Locally stored source content

Exact product and population

Product identity selected for the separately displayed source protocols below. Reference: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8f7f73b8-586a-4df0-935f-fecd4696c16c

Product and population scope

Adult Isavuconazonium sulfate (Cresemba). Use only the product, route, indication and renal-replacement setting explicitly stated in the source protocol selected below. Sources are alternatives to compare, not ingredients of a blended regimen.

SCOPE-isavuconazonium · Source section: Editorial scope; each clinical recommendation is separately attributed belowRenal section finder
Separate U.S. product-label layer

FDA / DailyMed dosing and renal information

Official

CRESEMBA - adult prodrug dose and renal statement

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NIH/NLM DailyMed - U.S. product labeling · Adults; named product and route only. Selected dosing and renal summary, not the full prescribing information.

Renal method: No renal-function dose bands specified for this summary.
Source date: DailyMed updated 2025-04-25.
Retrieved: 2026-09-05

Locally included source-specific summary. Regimen differences are not automatically resolved.

Dosing / renal protocol and limits

For adult invasive aspergillosis or mucormycosis, give 372 mg isavuconazonium sulfate IV or orally every 8 hours for 6 doses, then 372 mg once daily. Begin maintenance 12-24 hours after the final loading dose. Each 372-mg prodrug dose equals 200 mg isavuconazole. Infuse IV doses over at least 1 hour, never as a bolus.

No adjustment is needed for mild, moderate or severe renal impairment, including ESRD. Isavuconazole is not readily removed by dialysis. Pediatric regimens and nasogastric preparation instructions require their separate label sections; this card is adult-only.

RDM30-075-isavuconazonium-1 · Source locator: CRESEMBA - adult prodrug dose and renal statement; renal/dosing sections and stated qualifiers

Source identity and provenance
Source
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8f7f73b8-586a-4df0-935f-fecd4696c16c
Retrieved
2026-09-05
DailyMed Set ID
8f7f73b8-586a-4df0-935f-fecd4696c16c
Renal-function method
No renal-function dose bands specified for this summary.
Source date/version
DailyMed updated 2025-04-25.
Hash meaning
Locally authored summary text; not original SPL, HTML or PDF bytes
Local summary SHA-256
d76cdb8e7333a9c11a2211daf57b7cb262657b4d9b10ad3ceb177dabd9e5581d
Official

DailyMed CRESEMBA renal-impairment statement

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DailyMed / Astellas Pharma US, Inc. · CRESEMBA isavuconazonium sulfate capsules/injection; selected renal eligibility statement, not age/weight-specific complete dosing.

Renal method: Renal-impairment categories; indexed eGFR in trial description.
Source date: Source revision date not established in selected retrieval.
Retrieved: 2026-09-07

Qualified no-adjustment statement. Apply only to the population, product and renal range described in this source.

Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.

Renal dosing, restrictions and evidence limits

No dose adjustment is needed for mild, moderate or severe renal impairment, including ESRD. The clinical-trial description includes patients with eGFR below 60 mL/min/1.73 m2. This selected renal statement does not replace formulation-, age- and weight-specific dosing, interaction review or hepatic monitoring. No additional dialysis removal or post-HD supplement claim is inferred from the excerpt.

RDM43-official-isavuconazonium-f759c4c6b1-C1 · Source locator: Section 8.6 Renal Impairment.

Source identity and provenance
Source family
product_label
Source
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8f7f73b8-586a-4df0-935f-fecd4696c16c
Retrieved
2026-09-07
Exact label title
DailyMed CRESEMBA renal-impairment statement
DailyMed Set ID
8f7f73b8-586a-4df0-935f-fecd4696c16c
Labeler
Astellas Pharma US, Inc.
Renal-function method
Renal-impairment categories; indexed eGFR in trial description.
Source date/version
Source revision date not established in selected retrieval.
Hash meaning
SHA-256 of local authored summary only; not original HTML, PDF or SPL bytes.
Local summary SHA-256
68b448619408b662b19660c4f2f7e18bf52a8bf78d102c8b2f222770084a98a0
Separate handbook layer

Renal Drug Handbook cross-check

Handbook

Renal Drug Handbook, 5th edition - Isavuconazole (administered as isavuconazonium sulfate)

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UK Renal Pharmacy Group / CRC Press · Historical adult renal/RRT summary. U.S. product identity anchored to the separate locally included DailyMed label. This is not a current U.S. product label.

Renal method: Book table headed GFR (mL/min); its preface states renal adjustments generally derive from Cockcroft-Gault CrCl. Do not silently relabel as indexed eGFR.
Source date: 5th edition; 2019 copyright; historical reference
Retrieved: 2026-09-05

Historical handbook cross-check; not a current U.S. protocol

Historical renal / replacement-therapy guidance

The 20-50, 10-20 and <10 mL/min bands retain the usual indication-specific dose. PD, HD, high-flux and continuous therapy also retain usual doses; the book describes no dialytic removal. Its dose is expressed as 200 mg active isavuconazole every 8 hours for six doses then daily, beginning 12-24 hours after the final load. The U.S. CRESEMBA section expresses the equivalent as 372 mg prodrug. Do not confuse the masses.

HB30-isavuconazonium-1 · Source locator: Printed page 542: renal impairment, RRT and other information

Source-specific limits

Separate source recommendation, not proof of agreement or contemporary clinical validation. Dialysis predictions are retained with their original certainty.

Source identity and provenance
Retrieved
2026-09-05
Handbook page
5th edition, printed p. 542; uploaded PDF p. 561
Renal-function method
Book table headed GFR (mL/min); its preface states renal adjustments generally derive from Cockcroft-Gault CrCl. Do not silently relabel as indexed eGFR.
Source date/version
5th edition; 2019 copyright; historical reference
U.S. product identity basis
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8f7f73b8-586a-4df0-935f-fecd4696c16c
Hash meaning
Local paraphrase; original book not redistributed
Local summary SHA-256
107c0b00378911a5e40d88d5cff8157934862f4561614d5b27a2a0984292bc3f
Separate professional-source layer

University and professional protocols

Professional

UCSF - isavuconazonium: dosing units and dialysis

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UCSF Infectious Diseases Management Program · Adults; source-specific institutional guidance. Match route, indication and renal replacement modality.

Renal method: Qualitative no-adjustment guidance.
Source date: Revision date not stated in the reviewed page.
Retrieved: 2026-09-05

Locally included source-specific summary. Regimen differences are not automatically resolved.

Dosing / renal protocol and limits

The regimen is expressed as isavuconazonium: 372 mg IV/orally every 8 hours for six doses, then 372 mg daily. Each 372 mg prodrug dose corresponds to 200 mg isavuconazole.

UCSF retains this schedule without renal or hemodialysis reduction. Check interactions and use antifungal-level consultation when indicated. The prodrug and active-moiety dose numbers must not be interchanged.

RDM30-052-isavuconazonium-1 · Source locator: UCSF - isavuconazonium: dosing units and dialysis; renal/dosing sections and stated qualifiers

Source identity and provenance
Source
https://idmp.ucsf.edu/content/isavuconazole
Retrieved
2026-09-05
Renal-function method
Qualitative no-adjustment guidance.
Source date/version
Revision date not stated in the reviewed page.
Hash meaning
Locally authored summary text; not original SPL, HTML or PDF bytes
Local summary SHA-256
f1469207945dd4f2c847ea79dfde9a6ce662976618a5baf051429c51971d8f2b

Provenance and preservation

Additional summaries stored on this page: 2 official-label, 0 RX List, 1 professional, 1 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8f7f73b8-586a-4df0-935f-fecd4696c16c
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
multisource addition
Local text SHA-256
9945a7c03bd3735f620403d137b81acaaa5d3590eef2962dce9bb392dce2a85b
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

This page is an additional exact-product entry, not a recovered GlobalRPh monograph. Its primary scope text and separately attributed clinical summaries are locally included.

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