Inamrinone | GlobalRPh Renal Dosing Master

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Usual Dosing (Adults)

Give loading doses undiluted as supplied. Maintenance infusions may use normal or half-normal saline at 1 to 3 mg/mL; use diluted solutions within 24 hours. May administer through a Y-connector into a running dextrose infusion or directly into tubing.

Do not dilute directly in dextrose: a chemical interaction develops over 24 hours. Do not give furosemide in a line containing inamrinone: immediate precipitation occurs.

Start 0.75 mg/kg over 2 to 3 minutes, then maintenance 5 to 10 micrograms/kg/min. An additional 0.75 mg/kg loading dose may be given 30 minutes after initiation based on response. Usual total including loads should not exceed 10 mg/kg/day; limited studies support up to 18 mg/kg/day for shortened durations.

Loading-dose chart (undiluted):

Weight (kg)	30	40	50	60	70	80	90	100	110	120
Volume (mL)	4.5	6	7.5	9	10.5	12	13.5	15	16.5	18

The infusion chart requires 2.5 mg/mL (2500 micrograms/mL), prepared by equal volumes of inamrinone solution and saline. Example: three 20 mL vials (60 mL) plus 60 mL saline = 120 mL at 2.5 mg/mL.

Dose/weight	30 kg	40 kg	50 kg	60 kg	70 kg	80 kg	90 kg	100 kg	110 kg	120 kg
5 micrograms/kg/min, mL/hour	4	5	6	7	8	10	11	12	13	14
7.5 micrograms/kg/min, mL/hour	5	7	9	11	13	14	16	18	20	22
10 micrograms/kg/min, mL/hour	7	10	12	14	17	19	22	24	26	29

The source example: 70 kg requires 10.5 mL undiluted loading dose; at 7.5 micrograms/kg/min, use 13 mL/hour of 2.5 mg/mL. These are rounded source chart values.

Adjust rate/duration to response and adverse effects, reducing/titrating down as necessary. Expected concentration is approximately 3 micrograms/mL; cardiac-index increases are linearly related over 0.5 to 7 micrograms/mL, without observations above that range.

Improvement may include increased cardiac output, reduced wedge pressure, and less dyspnea, orthopnea and fatigue. CVP monitoring may help assess hypotension/fluid balance. Correct or adjust fluids/electrolytes beforehand. Do not use particulate or discolored products.

Renal Dosing

CrCl >10 mL/min: no change. CrCl <10: administer 50% to 75% of dose.

Hemodialysis

Specific guidelines not available. Refer to CrCl <10 dosing.

Source revision: Historical source; revision not established here | Retrieved: 2026-09-05. Retrieval date is not the revision date.

Source: https://globalrph.com/renal/inamrinone/

Scope: Preserved historical source; no fresh clinical approval GlobalRPh v6.6.

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Retrieved: 2026-09-05

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Original GlobalRPh protocol

Clinical facts and comments transcribed into a structured reading format. This is not a byte-for-byte HTML archive. Original source: https://globalrph.com/renal/inamrinone/

Usual Dosing (Adults)

Do not dilute directly in dextrose: a chemical interaction develops over 24 hours. Do not give furosemide in a line containing inamrinone: immediate precipitation occurs.

Loading-dose chart (undiluted):

Weight (kg)	30	40	50	60	70	80	90	100	110	120
Volume (mL)	4.5	6	7.5	9	10.5	12	13.5	15	16.5	18

The infusion chart requires 2.5 mg/mL (2500 micrograms/mL), prepared by equal volumes of inamrinone solution and saline. Example: three 20 mL vials (60 mL) plus 60 mL saline = 120 mL at 2.5 mg/mL.

Dose/weight	30 kg	40 kg	50 kg	60 kg	70 kg	80 kg	90 kg	100 kg	110 kg	120 kg
5 micrograms/kg/min, mL/hour	4	5	6	7	8	10	11	12	13	14
7.5 micrograms/kg/min, mL/hour	5	7	9	11	13	14	16	18	20	22
10 micrograms/kg/min, mL/hour	7	10	12	14	17	19	22	24	26	29

The source example: 70 kg requires 10.5 mL undiluted loading dose; at 7.5 micrograms/kg/min, use 13 mL/hour of 2.5 mg/mL. These are rounded source chart values.

GRPH-inamrinone-01 · Source section: Usual Dosing (Adults)Renal section finder

Renal Dosing

CrCl >10 mL/min: no change. CrCl <10: administer 50% to 75% of dose.

GRPH-inamrinone-02 · Source section: Renal DosingRenal section finder

Hemodialysis

Specific guidelines not available. Refer to CrCl <10 dosing.

GRPH-inamrinone-03 · Source section: HemodialysisRenal section finder

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 0 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source: https://globalrph.com/renal/inamrinone/
Source retrieval: 2026-09-05. This is not the source publication or label revision date.
Original source type: globalrph individual
Local text SHA-256: a09cbd4a25fcfcd1f36682a6bb8b332e08df273e4f7f1a08ba574c9cee9f2b5d
Import versus clinical validation: Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

The original individual GlobalRPh pages commonly cite NIH/NLM DailyMed and instruct readers to review the applicable package insert for updates. That historical reference is preserved as context; it is not counted as an independently retrieved current label.

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