GlobalRPh Renal Dosing Masterv7.4
Renal Dosing Master: fast drug lookup
Product-specific reference

Imipenem / cilastatin / relebactam (Recarbrio)

Read renal action and limits
Local official-label summarySource retrieved 2026-09-05See the evidence for this drug4 sources available - open source summaries, references and comparisons

Recarbrio

READ THE SOURCE-SPECIFIC ANSWER

Renal guidance at a glance

Cautions / source differences (1)
Review first - source-specific qualification

RECARBRIO: source applicability and renal evidence limits

Adult Cockcroft-Gault CrCl and pediatric indexed eGFR are distinct instructions. Matching numerical bands does not validate substitution between these methods or populations.

Before applying: Do not apply adult CrCl bands to pediatric indexed eGFR.

Evidence for this qualification

Selected-source comparison; independent clinician adjudication pending.

Use the renal measure and units named by this source. Confirm product, indication, age, stable versus changing kidney function, and exact dialysis modality. The selected summary is not a complete prescribing monograph. Renal method and dosing checklist

Choose a source to read (4)

Display order is not a clinical ranking. Date of retrieval is not the label revision date. Sources are never merged into one regimen. Other sources and conflicts remain below.

Official source

RECARBRIO: selected primary-label renal guidance and limits

This source only - not a merged recommendation

What matters first

Product: Adult IV RECARBRIO renal table only. Pediatric renal categories use a different measure and must be reviewed separately.

Renal action / finding
Adult renal bands below: every 6 hours over 30 minutes.
Evidence or dialysis limit
CrCl <15 without HD: not recommended unless HD starts within 48 hours; PD information inadequate.
Monitoring / application
Do not apply adult CrCl bands to pediatric indexed eGFR.

Selected-section summary, not a complete monograph. Independent clinician review remains pending. Read the exact renal measure, dates and full source below.

Product / population
Adult IV RECARBRIO renal table only. Pediatric renal categories use a different measure and must be reviewed separately.
Renal measure
Adult Cockcroft-Gault CrCl, mL/min; pediatric >=30 kg uses indexed eGFR, not this adult table
Source revision
Revision date not captured in selected review; retrieval date is not revision date.
Retrieved
2026-11-07 (not the revision date)
Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.
Before using this finding

CrCl <15 without HD: not recommended unless HD starts within 48 hours; PD information inadequate.

Selected renal section, not a complete prescribing monograph. A label and its mirror are not independent evidence.

Sections 2.1, 2.3 and 2.4; adult Table 2

Limits that apply to these rows

Read the complete source-specific limitations above and below this table. No patient dose is calculated.

Source-specific renal instructions
Adult CrCl (mL/min)Total combination dose
>=901.25 g
60-891 g
30-590.75 g
15-29, not on HD0.5 g
Hemodialysis0.5 g; post-HD timing
<15, no HDNot recommended; see 48-hour exception
Read the retained text before reformatting

Adult doses below are total combination grams, infused over 30 minutes every 6 hours; components remain in the 2:2:1 ratio. For HD, dose after the session and time subsequent intervals from its end. Do not administer below CrCl 15 without HD unless HD begins within 48 hours. Peritoneal-dialysis information is inadequate. The pediatric >=30 kg table uses indexed eGFR; renal impairment below 30 kg has no recommended regimen.

Source revision: Revision date not captured in selected review; retrieval date is not revision date. | Retrieved: 2026-11-07. Retrieval date is not the revision date.

Source: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=be32f468-738b-40df-a425-591e12f65159

Scope: Selected sections checked against the identified source; not a complete monograph or independent clinician approval. GlobalRPh v7.4.

Full source card / provenance

All sources, comparison tools and evidence navigation
Source-specific interpretation

What the dialysis evidence actually supports

Removal information alone does not define a maintenance dose, supplemental dose or dialysis schedule. A reported regimen still requires its product, indication, renal measure and dialysis assumptions to match the patient.

RECARBRIO: selected primary-label renal guidance and limits

Source retrieved 2026-11-07 - confirm current applicability

A regimen is reported in selected content

Read the source and its limits

RECARBRIO: selected RX renal passage

Source retrieved 2026-11-07 - confirm current applicability

A regimen is reported in selected content

Read the source and its limits

These manual classifications apply only to the identified selected sections, not every retained source or the entire prescribing information. They are not dosing clearance.

Source-first renal review

Evidence sources and renal implications

Choose a source to jump directly to its locally stored result. Qualitative precautions and evidence gaps remain visible even when no numerical clearance schedule is supplied.

Read 1 source difference / applicability notes

Official product label

RECARBRIO: selected primary-label renal guidance and limits

Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.
Before using this finding

CrCl <15 without HD: not recommended unless HD starts within 48 hours; PD information inadequate.

Dialysis evidence: A regimen is reported in selected content

Adult IV RECARBRIO renal table only. Pediatric renal categories use a different measure and must be reviewed separately.

Renal method: Adult Cockcroft-Gault CrCl, mL/min; pediatric >=30 kg uses indexed eGFR, not this adult table
Retrieved: 2026-11-07

Read local renal resultOpen this source quick answerOpen original reference
GlobalRPh RX List

RECARBRIO: selected RX renal passage

Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.
Before using this finding

CrCl <15 without HD: not recommended unless HD starts within 48 hours; PD information inadequate.

Dialysis evidence: A regimen is reported in selected content

Adult IV RECARBRIO renal table only. Pediatric renal categories use a different measure and must be reviewed separately.

Renal method: Adult Cockcroft-Gault CrCl, mL/min; pediatric >=30 kg uses indexed eGFR, not this adult table
Retrieved: 2026-11-07

Read local renal resultOpen this source quick answerOpen original reference

Source presence is not independent validation. A label mirror is not a second independent source; review the original reference and exact formulation.

Product / population check

Confirm the exact formulation before using a renal source

These links compare product identities, not interchangeable doses. A selected summary is not a complete prescribing monograph.

Source-specific review points

RECARBRIO: source applicability and renal evidence limits

Read the attributed comparison notes and source cards below. No conflict has been silently adjudicated.

Source-quality holds
Find text within this drug
Find a term without leaving this drug

Search the stored clinical text

Locate a word or phrase within this drug's source summaries. Choose all sources or one source to focus the search. The selection never hides warnings or source text, changes a dose, or proves that a renal finding is absent.

Find:

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All source summaries, original wording and provenance
Before applying a renal protocol

Check the setting. Compare whole sources.

No patient-specific dose is calculated. Context choices only display reminders; they do not validate, hide or change any regimen.

Share a reproducible source review

Choose sources below, then open a print-ready comparison with product scope, renal method, dates and cautions. Links can pin the exact local cards; they never contain patient values or choose a dose.

Open / share selected sources
Jump to renal guidanceRead 1 difference / caution notesClinician guide

Select two distinct source versions. The complete stored summaries will appear below.

Build a source-review outline for documentation

This creates a blank decision outline with the source identities you select, not a dose recommendation or completed clinical assessment. No patient fields are collected, saved or sent. Complete the clinical decisions in your approved documentation system.

Choose one or two sources above or use the source checkboxes below.

Renal-context checklist: population, kidney trend and dialysis

These prompts are a reading aid, not a prescription checklist or proof that all requirements have been met. No selections are stored or sent to a server.

Read the exact source scope, renal metric and date before selecting a row. No applicability assessment has been performed.

See source-specific renal methods and the clinical interpretation guide for the supporting context.

Read before choosing a regimen

Source differences and product cautions

Search differences across all drugs

These are specific issues found during source review, not an automated judgment that one source is universally correct. A label mirror and its original label are not independent evidence.

Source scope / renal recommendation differences

RECARBRIO: source applicability and renal evidence limits

Adult Cockcroft-Gault CrCl and pediatric indexed eGFR are distinct instructions. Matching numerical bands does not validate substitution between these methods or populations.

How to use this: Do not apply adult CrCl bands to pediatric indexed eGFR.

RECARBRIO: selected primary-label renal guidance and limitsRECARBRIO: selected RX renal passage

Selected-source comparison; independent clinician adjudication pending.

Go directly to the relevant source section

Renal dosing and precautions

Choose a source, then jump to its renal or dialysis section. These links locate stored text; they do not merge regimens or certify that sources agree.

Independent clinical review is pending. These selected summaries are not an approved institutional dosing protocol. Confirm the exact product, the complete current source and local policy before use.
Official source

RECARBRIO: selected primary-label renal guidance and limits

Adult IV RECARBRIO renal table only. Pediatric renal categories use a different measure and must be reviewed separately.

Method: Adult Cockcroft-Gault CrCl, mL/min; pediatric >=30 kg uses indexed eGFR, not this adult table

Read this complete source summary
Rxlist source

RECARBRIO: selected RX renal passage

Adult IV RECARBRIO renal table only. Pediatric renal categories use a different measure and must be reviewed separately.

Method: Adult Cockcroft-Gault CrCl, mL/min; pediatric >=30 kg uses indexed eGFR, not this adult table

Read this complete source summary

No dialysis or renal heading shown? Read the complete source summary. Absence of a heading is not evidence that dose adjustment is unnecessary.

Compare or copy source versions

All content below is stored locally. Read a whole source version; do not combine its dose with another source's interval, renal metric or dialysis assumptions.

Original content / product scopeRECARBRIO - adult renal dosingRECARBRIO: selected primary-label renal guidance and limitsRECARBRIO: selected RX renal passageUCSF - RECARBRIO
Choose two source checkboxes below.
Exact product and population matter. This added page contains locally stored, source-specific clinical summaries. Historical handbook information, when present, is identified separately and may conflict with U.S. labeling. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.
Locally stored source content

Exact product and population

Product identity selected for the separately displayed source protocols below. Reference: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=be32f468-738b-40df-a425-591e12f65159

Product and population scope

Adult Imipenem / cilastatin / relebactam (Recarbrio). Use only the product, route, indication and renal-replacement setting explicitly stated in the source protocol selected below. Sources are alternatives to compare, not ingredients of a blended regimen.

SCOPE-imipenem-cilastatin-relebactam · Source section: Editorial scope; each clinical recommendation is separately attributed belowRenal section finder
Separate U.S. product-label layer

FDA / DailyMed dosing and renal information

Official

RECARBRIO - adult renal dosing

Open original reference

Open / share this exact local source

NIH/NLM DailyMed - U.S. product labeling · Adults; exact named U.S. product. Selected dose/renal summary, not the full prescribing information.

Renal method: Cockcroft-Gault CrCl, mL/min, for adults.
Source date: Label updated 2025-12-09.
Retrieved: 2026-09-05

Locally included source-specific summary. Regimen differences are not automatically resolved.

Dosing / renal protocol and limits

All adult doses are total combination amounts, given IV every 6 hours over 30 minutes.

Cockcroft-Gault CrCl (mL/min)Dose
>=901.25 g (500/500/250 mg)
60-891 g (400/400/200 mg)
30-590.75 g (300/300/150 mg)
15-29 without HD0.5 g (200/200/100 mg)
Receiving HD0.5 g (200/200/100 mg)

Components are imipenem/cilastatin/relebactam. Below 15 without HD, use is not recommended; do not administer unless HD will begin within 48 hours. For established HD, give after the session and time subsequent intervals from session end. Peritoneal-dialysis dosing is not established. The label course is 4-14 days according to indication/response. Pediatric weight/eGFR schedules are separate.

RDM30-070-imipenem-cilastatin-relebactam-1 · Source locator: RECARBRIO - adult renal dosing; renal/dosing sections and stated qualifiers

Source identity and provenance
Source
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=be32f468-738b-40df-a425-591e12f65159
Retrieved
2026-09-05
DailyMed Set ID
be32f468-738b-40df-a425-591e12f65159
Renal-function method
Cockcroft-Gault CrCl, mL/min, for adults.
Source date/version
Label updated 2025-12-09.
Hash meaning
Locally authored summary text; not original SPL, HTML or PDF bytes
Local summary SHA-256
03b7654bfa175e14d2a613f6886ec6dc4ea4a70d9ad5dad12970c7e7127f1e9f
Official

RECARBRIO: selected primary-label renal guidance and limits

Open original reference

Open / share this exact local source

DailyMed / product prescribing information · Adult IV RECARBRIO renal table only. Pediatric renal categories use a different measure and must be reviewed separately.

Renal method: Adult Cockcroft-Gault CrCl, mL/min; pediatric >=30 kg uses indexed eGFR, not this adult table
Source date: Revision date not captured in selected review; retrieval date is not revision date.
Retrieved: 2026-11-07

Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.
Before using this finding

CrCl <15 without HD: not recommended unless HD starts within 48 hours; PD information inadequate.

Dialysis evidence: A regimen is reported in selected content

Selected sections checked against the identified source; not a complete monograph or independent clinician approval.

Sections 2.1, 2.3 and 2.4; adult Table 2

Limits that apply to these rows

Read the complete source-specific limitations above and below this table. No patient dose is calculated.

Source-specific renal instructions
Adult CrCl (mL/min)Total combination dose
>=901.25 g
60-891 g
30-590.75 g
15-29, not on HD0.5 g
Hemodialysis0.5 g; post-HD timing
<15, no HDNot recommended; see 48-hour exception
Read the retained text before reformatting

Adult doses below are total combination grams, infused over 30 minutes every 6 hours; components remain in the 2:2:1 ratio. For HD, dose after the session and time subsequent intervals from its end. Do not administer below CrCl 15 without HD unless HD begins within 48 hours. Peritoneal-dialysis information is inadequate. The pediatric >=30 kg table uses indexed eGFR; renal impairment below 30 kg has no recommended regimen.

RDM72-imipenem-cilastatin-relebactam-label-1 · Source locator: Sections 2.1, 2.3 and 2.4; adult Table 2

Source-specific limits

Selected renal section, not a complete prescribing monograph. A label and its mirror are not independent evidence.

Source identity and provenance
Source family
product_label
Source
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=be32f468-738b-40df-a425-591e12f65159
Retrieved
2026-11-07
Renal-function method
Adult Cockcroft-Gault CrCl, mL/min; pediatric >=30 kg uses indexed eGFR, not this adult table
Source date/version
Revision date not captured in selected review; retrieval date is not revision date.
Hash meaning
Locally authored summary text; not original source HTML, XML or PDF bytes
Local summary SHA-256
8945473e3b6781e2af908066eafad3b55b0054bd22220196671a81c4e928416b
Locally imported selected renal sections

GlobalRPh RX List renal information

Rxlist

RECARBRIO: selected RX renal passage

Open original reference

Open / share this exact local source

GlobalRPh RX List / label mirror · Adult IV RECARBRIO renal table only. Pediatric renal categories use a different measure and must be reviewed separately.

Renal method: Adult Cockcroft-Gault CrCl, mL/min; pediatric >=30 kg uses indexed eGFR, not this adult table
Source date: Revision date not established in reviewed mirror passage.
Retrieved: 2026-11-07

Label mirror, not independent corroboration. This is selected locally stored RX List content. Full monograph import and current official-label review are not implied.
Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.
Before using this finding

CrCl <15 without HD: not recommended unless HD starts within 48 hours; PD information inadequate.

Dialysis evidence: A regimen is reported in selected content

Selected sections checked against the identified source; not a complete monograph or independent clinician approval.

Sections 2.1, 2.3 and 2.4; adult Table 2

The mirror provides a reduced adult CrCl schedule with post-HD timing. Pediatric renal guidance must not be inferred from an adult clearance value; the current primary label distinguishes adult CrCl from pediatric indexed eGFR.

RDM72-imipenem-cilastatin-relebactam-rx-1 · Source locator: Sections 2.1, 2.3 and 2.4; adult Table 2

Source-specific limits

Selected renal section, not a complete prescribing monograph. A label and its mirror are not independent evidence.

Source identity and provenance
Source family
product_label_mirror
Source
https://globalrph.com/rx-list/recarbrio-drug/
Retrieved
2026-11-07
Renal-function method
Adult Cockcroft-Gault CrCl, mL/min; pediatric >=30 kg uses indexed eGFR, not this adult table
Source date/version
Revision date not established in reviewed mirror passage.
Hash meaning
Locally authored summary text; not original source HTML, XML or PDF bytes
Local summary SHA-256
8e751884a6ff5b18377353e1f4a00c5b9bfd44f0fb07c1b6d5aefe47e7e2aaf5
Separate professional-source layer

University and professional protocols

Professional

UCSF - RECARBRIO

Open original reference

Open / share this exact local source

UCSF Infectious Diseases Management Program · Adults; imipenem/cilastatin/relebactam total combined IV dose; not imipenem/cilastatin alone.

Renal method: CrCl in mL/min where specified; no equation inferred.
Source date: Revision date not stated in the reviewed page.
Retrieved: 2026-09-05

Locally included source-specific summary. Regimen differences are not automatically resolved.

Dosing / renal protocol and limits

Total combined IV doses every 6 hours: CrCl >90, 1.25 g; 60-90, 1 g; 30-60, 750 mg; 15-30, 500 mg. A 1.25 g dose comprises imipenem 500 mg, cilastatin 500 mg and relebactam 250 mg.

IHD: 500 mg every 6 hours. Continuous-HD dosing is not supplied. The website's adjacent renal ranges overlap at their exact endpoints; use the separately listed label boundaries when an exact 30, 60 or 90 mL/min value must be assigned.

RDM30-009-imipenem-cilastatin-relebactam-1 · Source locator: UCSF - RECARBRIO; renal/dosing sections and stated qualifiers

Source identity and provenance
Source
https://idmp.ucsf.edu/content/imipenem-cilastatin-relebactam
Retrieved
2026-09-05
Renal-function method
CrCl in mL/min where specified; no equation inferred.
Source date/version
Revision date not stated in the reviewed page.
Hash meaning
Locally authored summary text; not original SPL, HTML or PDF bytes
Local summary SHA-256
927e797e871f853cca711d6e593343cebf7a9f0d8ad0338d8e165f50ccc7097c

Provenance and preservation

Additional summaries stored on this page: 2 official-label, 1 RX List, 1 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=be32f468-738b-40df-a425-591e12f65159
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
multisource addition
Local text SHA-256
f557145282a4fc6f2dfcd296d43cd8eb7ced4875174648638d9729bcd70a137c
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

This page is an additional exact-product entry, not a recovered GlobalRPh monograph. Its primary scope text and separately attributed clinical summaries are locally included.

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