GlobalRPh RX List - FANAPT
- Product / population
- Oral iloperidone; selected single-dose renal pharmacokinetic study.
- Renal measure
- CrCl <30 mL/min; not a validated dialysis dosing method.
RX mirror: this is not independent corroboration of its underlying label. Check dated-label and formulation limitations.
Renal dosing, restrictions and evidence limits
After a single 3 mg dose in severe renal impairment, iloperidone exposure increased 24%; metabolite P88 exposure decreased 6%, and P95 exposure increased 52%. These observations are not a renal dose-reduction formula. The selected paragraph does not provide a dialysis schedule or justify multiplying the dose by an exposure percentage.