GlobalRPh RX List - NeoProfen
- Product / population
- NeoProfen for clinically significant PDA in premature infants 500-1500 g and no more than 32 weeks gestational age; doses based on birth weight.
- Renal measure
- Urine output in mL/kg/hour; laboratory evidence of renal recovery.
RX mirror: this is not independent corroboration of its underlying label. Check dated-label and formulation limitations.
Renal dosing, restrictions and evidence limits
The labeled course is 10 mg/kg IV followed by 5 mg/kg at 24 and 48 hours, using birth weight. If anuria or urine output below 0.6 mL/kg/hour is present when dose two or three is due, give no further dose until laboratory studies show renal recovery to normal. This is a withholding rule, not a reduced adult-NSAID regimen. Review the full neonatal contraindications and PDA assessment before treatment.