Hydroxocobalamin cyanide antidote - CYANOKIT | GlobalRPh Renal Dosing Master

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Renal injury and laboratory or dialysis-device interference can coexist

The source describes genuine kidney injury, analyzer-dependent creatinine interference and false dialysis blood-leak alarms. These are separate problems and can occur in the same clinical episode.

Before applying: Notify the laboratory and dialysis team and reassess the measurement method and device. Do not dismiss an apparent creatinine rise automatically or derive a renal antidote reduction from assay interference.

Also check: Renal injury and laboratory or dialysis-device interference can coexist

Rxlist source

GlobalRPh RX List - CYANOKIT

Product / population: IV hydroxocobalamin antidote for cyanide poisoning; not low-dose vitamin B12 replacement
Renal measure: No established CrCl regimen; renal monitoring and assay/dialysis interference

RX mirror: this is not independent corroboration of its underlying label. Check dated-label and formulation limitations.

Renal dosing, restrictions and evidence limits

Renal impairment has not been studied sufficiently to establish a renal dose-adjustment regimen. Acute renal injury, including tubular necrosis and urinary calcium oxalate crystals, has been reported; some cases required hemodialysis. Monitor renal function, including BUN and creatinine, for seven days after treatment.

The red chromophore can cause analyzer-dependent interference, including falsely increased creatinine on some methods. It can also trigger false blood-leak detection and dialysis-machine shutdown. Alert the laboratory and dialysis team; an apparent creatinine rise requires interpretation in context, not automatic attribution solely to assay interference. These precautions do not justify delaying emergency antidote treatment.

Source revision: May 2021 | Retrieved: 2026-09-07. Retrieval date is not the revision date.

Source: https://globalrph.com/rx-list/cyanokit-drug/

Scope: Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph. GlobalRPh v6.6.

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GlobalRPh RX List

GlobalRPh RX List - CYANOKIT

Monitoring or renal-toxicity guidance. This finding concerns risk or surveillance; it may not establish a dose adjustment.

IV hydroxocobalamin antidote for cyanide poisoning; not low-dose vitamin B12 replacement

Renal method: No established CrCl regimen; renal monitoring and assay/dialysis interference
Retrieved: 2026-09-07

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monitoring and measurement

Renal injury and laboratory or dialysis-device interference can coexist

The source describes genuine kidney injury, analyzer-dependent creatinine interference and false dialysis blood-leak alarms. These are separate problems and can occur in the same clinical episode.

How to use this: Notify the laboratory and dialysis team and reassess the measurement method and device. Do not dismiss an apparent creatinine rise automatically or derive a renal antidote reduction from assay interference.

GlobalRPh RX List - CYANOKIT

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Rxlist source

GlobalRPh RX List - CYANOKIT

IV hydroxocobalamin antidote for cyanide poisoning; not low-dose vitamin B12 replacement

Method: No established CrCl regimen; renal monitoring and assay/dialysis interference

Renal dosing, restrictions and evidence limits Read this complete source summary

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Original content / product scope GlobalRPh RX List - CYANOKIT

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Product identity selected for the separately displayed source protocols below. Reference: https://globalrph.com/rx-list/cyanokit-drug/

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IV hydroxocobalamin antidote for cyanide poisoning; not low-dose vitamin B12 replacement

RDM38-SCOPE-hydroxocobalamin-cyanokit · Source section: Selected source product scopeRenal section finder

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GlobalRPh RX List - CYANOKIT

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GlobalRPh-hosted RX List · IV hydroxocobalamin antidote for cyanide poisoning; not low-dose vitamin B12 replacement

Renal method: No established CrCl regimen; renal monitoring and assay/dialysis interference
Source date: May 2021
Retrieved: 2026-09-07

Label mirror, not independent corroboration. This is selected locally stored RX List content. Full monograph import and current official-label review are not implied.

Monitoring or renal-toxicity guidance. This finding concerns risk or surveillance; it may not establish a dose adjustment.

Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.

Renal dosing, restrictions and evidence limits

RDM38-rxlist-hydroxocobalamin-cyanokit-bb8b478ffc-C1 · Source locator: Precautions: renal injury, laboratory interference and clinical methods; renal impairment

Source identity and provenance

Source family: product_label_mirror
Source: https://globalrph.com/rx-list/cyanokit-drug/
Retrieved: 2026-09-07
Renal-function method: No established CrCl regimen; renal monitoring and assay/dialysis interference
Source date/version: May 2021
Hash meaning: SHA-256 of local authored summary only; not original HTML, PDF or SPL bytes.
Local summary SHA-256: 97391dea6e8e6bce826b59a44d4ee30b151cfbba825621e4968fc8f3f2326377

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 1 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source: https://globalrph.com/rx-list/cyanokit-drug/
Source retrieval: 2026-09-07. This is not the source publication or label revision date.
Original source type: rxlist summary
Local text SHA-256: c41be8e9004a07a97a21392a6cb127515e8a465ef402971ff913e0f9d2c3e07f
Import versus clinical validation: Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

This page is an additional exact-product entry, not a recovered GlobalRPh monograph. Its primary scope text and separately attributed clinical summaries are locally included.

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