Granisetron extended-release injection (SUSTOL) | GlobalRPh Renal Dosing Master

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SUSTOL: depot formulation matters despite IV granisetron PK

SUSTOL has a longer minimum interval in moderate impairment and avoidance in severe impairment. The separate IV KYTRIL single-dose clearance observation cannot be applied to the polymer depot.

Before applying: Check route and release mechanism; read the local IV record only as a related, noninterchangeable product.

Also check: SUSTOL: depot formulation matters despite IV granisetron PK

Rxlist source

GlobalRPh RX List - Granisetron ER (Sustol)

Product / population: SUSTOL 10 mg subcutaneous extended-release product for chemotherapy-associated nausea/vomiting; not IV KYTRIL.
Renal measure: Creatinine clearance (mL/min).

RX mirror: this is not independent corroboration of its underlying label. Check dated-label and formulation limitations.

Dose and route separately confirmed in turn948264view8.

Renal dosing, restrictions and evidence limits

The usual product dose is 10 mg subcutaneously on day 1 before the specified chemotherapy, with the accompanying antiemetic regimen. At CrCl 30-59, do not administer more often than every 14 days. Avoid SUSTOL below CrCl 30. The polymer vehicle's elimination in renal impairment is uncharacterized; renal restrictions cannot be dismissed because granisetron itself is mainly metabolized hepatically. Do not substitute IV granisetron pharmacokinetic findings for this long-acting formulation's instructions.

Source revision: Source revision date not established in selected retrieval. | Retrieved: 2026-09-07. Retrieval date is not the revision date.

Source: https://globalrph.com/rx-list/sustol-drug/

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GlobalRPh RX List

GlobalRPh RX List - Granisetron ER (Sustol)

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SUSTOL 10 mg subcutaneous extended-release product for chemotherapy-associated nausea/vomiting; not IV KYTRIL.

Renal method: Creatinine clearance (mL/min).
Retrieved: 2026-09-07

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formulation distinction

SUSTOL: depot formulation matters despite IV granisetron PK

SUSTOL has a longer minimum interval in moderate impairment and avoidance in severe impairment. The separate IV KYTRIL single-dose clearance observation cannot be applied to the polymer depot.

How to use this: Check route and release mechanism; read the local IV record only as a related, noninterchangeable product.

GlobalRPh RX List - Granisetron ER (Sustol)Granisetron injection (KYTRIL)

Source-specific interpretation; independent clinician adjudication pending.

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Rxlist source

GlobalRPh RX List - Granisetron ER (Sustol)

SUSTOL 10 mg subcutaneous extended-release product for chemotherapy-associated nausea/vomiting; not IV KYTRIL.

Method: Creatinine clearance (mL/min).

Renal dosing, restrictions and evidence limits Read this complete source summary

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Original content / product scope GlobalRPh RX List - Granisetron ER (Sustol)

Exact product and population matter. This added page contains locally stored, source-specific clinical summaries. Historical handbook information, when present, is identified separately and may conflict with U.S. labeling. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.

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Exact product and population

Product identity selected for the separately displayed source protocols below. Reference: https://globalrph.com/rx-list/sustol-drug/

Exact product and population

SUSTOL 10 mg subcutaneous extended-release product for chemotherapy-associated nausea/vomiting; not IV KYTRIL.

RDM39-SCOPE-granisetron-sustol-sc · Source section: Selected source product scopeRenal section finder

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GlobalRPh RX List - Granisetron ER (Sustol)

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GlobalRPh-hosted RX List · SUSTOL 10 mg subcutaneous extended-release product for chemotherapy-associated nausea/vomiting; not IV KYTRIL.

Renal method: Creatinine clearance (mL/min).
Source date: Source revision date not established in selected retrieval.
Retrieved: 2026-09-07

Label mirror, not independent corroboration. This is selected locally stored RX List content. Full monograph import and current official-label review are not implied.

Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.

Renal dosing, restrictions and evidence limits

RDM39-rxlist-granisetron-sustol-sc-fc15ac27e0-C1 · Source locator: Selected renal dosing, use in renal impairment, warnings and clinical pharmacology subsections; see named sections in summary.

Source-specific limits

Dose and route separately confirmed in turn948264view8.

Source identity and provenance

Source family: product_label_mirror
Source: https://globalrph.com/rx-list/sustol-drug/
Retrieved: 2026-09-07
Renal-function method: Creatinine clearance (mL/min).
Source date/version: Source revision date not established in selected retrieval.
Hash meaning: SHA-256 of local authored summary only; not original HTML, PDF or SPL bytes.
Local summary SHA-256: 88455efeb30692419730213463e9d35a717aa59bfbfe0df8bf2bc1de9ed8e31d

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 1 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source: https://globalrph.com/rx-list/sustol-drug/
Source retrieval: 2026-09-07. This is not the source publication or label revision date.
Original source type: rxlist summary
Local text SHA-256: 91f012cebeb4fec30d090e0289a1289fa122fff1edf832e9c74f16ae105fce47
Import versus clinical validation: Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

This page is an additional exact-product entry, not a recovered GlobalRPh monograph. Its primary scope text and separately attributed clinical summaries are locally included.

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