GlobalRPh Renal Dosing Masterv6.6
GlobalRPh source record

Gentamicin

GlobalRPh source pageBase record retrieved 2026-09-05See the evidence for this drug2 sources available - open source summaries, references and comparisons

Garamycin

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Professional source

Stanford - Hartford initial interval selection

Product / population
Adults; gram-negative Hartford approach, not endocarditis synergy or cystic fibrosis
Renal measure
CrCl mL/min plus measured aminoglycoside level

Dosing / renal protocol and limits

Gentamicin, adult Hartford method: 7 mg/kg IV; CrCl >=60 every 24 hours, 40-59 every 36 hours, 30-39 every 48 hours. Not recommended below 30, on HD or CRRT. Check a level 8-12 hours after dose one and use the actual nomogram. Exclude pregnancy, major burns and significant ascites; use adjusted weight for obesity. Initial schedule only.

Source revision: Revision date not stated in the reviewed page. | Retrieved: 2026-09-05. Retrieval date is not the revision date.

Source: https://med.stanford.edu/content/dam/sm/bugsanddrugs/documents/antimicrobial-dosing-protocols/SHC-Aminoglycoside-Dosing-Guide.pdf

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Retrieved: 2026-09-05

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Professional guidance

Stanford - Hartford initial interval selection

Adults; gram-negative Hartford approach, not endocarditis synergy or cystic fibrosis

Renal method: CrCl mL/min plus measured aminoglycoside level
Retrieved: 2026-09-05

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Original content / product scopeStanford - Hartford initial interval selection
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Historical source content is not a current prescription. Original GlobalRPh recommendations are preserved, not automatically certified as current. Product-label and professional additions below are separately attributed. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.

Important source distinctions

Historical endocarditis prophylaxis statements are retained for continuity, not current procedure-specific guidance. Do not apply conventional intervals to an extended-interval regimen automatically.

Locally stored source content

Original GlobalRPh protocol

Clinical facts and comments transcribed into a structured reading format. This is not a byte-for-byte HTML archive. Original source: https://globalrph.com/renal/gentamicin/

Usual Dosing (Adults)

Adults IM/IV systemic severe life-threatening infections: conventional 2 to 2.5 mg/kg/dose every 8 to 12 hours. Higher initial doses may be considered in selected patients with expanded extracellular water (edema, septic shock, postoperative or trauma) to obtain adequate early peaks. Some clinicians suggest 4 to 7 mg/kg once daily with normal renal function; the source describes similar efficacy and similar or possibly less toxicity versus conventional dosing.

Urinary tract infection: 1.5 mg/kg/dose every 8 hours. Gram-positive synergy: 1 mg/kg/dose (no interval specified in this source sentence).

Historical endocarditis prevention: dental/oral/upper respiratory procedures, 1.5 mg/kg (maximum 80 mg) with ampicillin 1 to 2 g, 30 minutes before procedure. GI/GU surgery: 1.5 mg/kg (maximum 80 mg) with ampicillin 2 g, 30 minutes before procedure.

GRPH-gentamicin-01 · Source section: Usual Dosing (Adults)Renal section finder

Renal Dosing

Conventional intervals: CrCl >=60 mL/min every 8 hours; 40 to 60 every 12 hours; 20 to 40 every 24 hours; <20 give loading dose then monitor levels. High-dose therapy: may extend interval (e.g. every 48 hours) in moderate impairment, CrCl 30 to 59, and/or adjust based on serum concentrations.

GRPH-gentamicin-02 · Source section: Renal DosingRenal section finder

Hemodialysis

Dialyzable. The source states about 30% aminoglycoside removal during 4 hours of HD. Give after dialysis and follow levels.

GRPH-gentamicin-03 · Source section: HemodialysisRenal section finder
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University and professional protocols

Professional

Stanford - Hartford initial interval selection

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Stanford Health Care · Adults; gram-negative Hartford approach, not endocarditis synergy or cystic fibrosis

Renal method: CrCl mL/min plus measured aminoglycoside level
Source date: Revision date not stated in the reviewed page.
Retrieved: 2026-09-05

Locally included source-specific summary. Regimen differences are not automatically resolved.

Dosing / renal protocol and limits

Gentamicin, adult Hartford method: 7 mg/kg IV; CrCl >=60 every 24 hours, 40-59 every 36 hours, 30-39 every 48 hours. Not recommended below 30, on HD or CRRT. Check a level 8-12 hours after dose one and use the actual nomogram. Exclude pregnancy, major burns and significant ascites; use adjusted weight for obesity. Initial schedule only.

RDM30-104-gentamicin-1 · Source locator: Stanford - Hartford initial interval selection; renal/dosing sections and stated qualifiers

Source identity and provenance
Source
https://med.stanford.edu/content/dam/sm/bugsanddrugs/documents/antimicrobial-dosing-protocols/SHC-Aminoglycoside-Dosing-Guide.pdf
Retrieved
2026-09-05
Renal-function method
CrCl mL/min plus measured aminoglycoside level
Source date/version
Revision date not stated in the reviewed page.
Hash meaning
Locally authored summary text; not original SPL, HTML or PDF bytes
Local summary SHA-256
22a04eb8644d3a2c61122faa52cfd99b407602813ecaf1bb2c946496a87db0ca

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 0 RX List, 1 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://globalrph.com/renal/gentamicin/
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
globalrph individual
Local text SHA-256
f7ae15bd4a17184ad6bfaf8e2e5bfd6a7c8cf500894960dcb364db9ad084fe68
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

The original individual GlobalRPh pages commonly cite NIH/NLM DailyMed and instruct readers to review the applicable package insert for updates. That historical reference is preserved as context; it is not counted as an independently retrieved current label.

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