GlobalRPh Renal Dosing Masterv6.6
GlobalRPh source record

Zonisamide capsules

Local RX List renal extractBase record retrieved 2026-09-05See the evidence for this drug2 sources available - open source summaries, references and comparisons
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Rxlist source

GlobalRPh RX List - ZONEGRAN

Product / population
Oral zonisamide capsules; renal restriction and toxicity surveillance.
Renal measure
Estimated GFR, printed as mL/min; normalization not specified in this passage.

RX mirror: this is not independent corroboration of its underlying label. Check dated-label and formulation limitations.

Renal dosing, restrictions and evidence limits

The source advises against use when estimated GFR is below 50 mL/min because renal dosing and toxicity experience are insufficient. Its printed unit is mL/min, without an indexed denominator. Stop treatment if acute renal failure develops or creatinine/BUN rises persistently to a clinically significant extent. Renal surveillance is distinct from the separate metabolic-acidosis and stone precautions. Do not substitute a guessed lower dose for the source restriction.

Source revision: Source revision date not established in selected retrieval. | Retrieved: 2026-09-07. Retrieval date is not the revision date.

Source: https://globalrph.com/rx-list/zonegran-drug/

Scope: Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph. GlobalRPh v6.6.

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Evidence sources and renal implications

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Preserved GlobalRPh source

Preserved original GlobalRPh source

Preserved historical content; not revalidated as current prescribing guidance.

Renal method: Read the measure and population stated in the original source sections.
Retrieved: 2026-09-05

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GlobalRPh RX List

GlobalRPh RX List - ZONEGRAN

Restriction or avoidance guidance. Read the specific threshold, age, formulation and dialysis exclusions; do not generalize across products.

Oral zonisamide capsules; renal restriction and toxicity surveillance.

Renal method: Estimated GFR, printed as mL/min; normalization not specified in this passage.
Retrieved: 2026-09-07

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Source presence is not independent validation. A label mirror is not a second independent source; review the original reference and exact formulation.

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Renal dosing and precautions

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New source summary - independent clinical review pending. Summaries of the identified label sections are included locally. Source import and numeric transcription checks are not independent two-reference validation. Do not treat this card as an approved institutional dosing protocol.

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Original content / product scopeGlobalRPh RX List - ZONEGRAN
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Historical source content is not a current prescription. Original GlobalRPh recommendations are preserved, not automatically certified as current. Product-label and professional additions below are separately attributed. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.
Locally stored source content

Original GlobalRPh protocol

Clinical facts and comments transcribed into a structured reading format. This is not a byte-for-byte HTML archive. Original source: https://globalrph.com/renal/medications-with-general-renal-dosing-statements/

GlobalRPh general renal statement

Dosing - Patients with Renal or Hepatic Disease: Because zonisamide is metabolized in the liver and excreted by the kidneys, patients with renal or hepatic disease should be treated with caution, and might require slower titration and more frequent monitoring.

Renal Insufficiency: Single 300 mg zonisamide doses were administered to three groups of volunteers. Group 1 was a healthy group with a creatinine clearance ranging from 70 to 152 mL/min. Group 2 and Group 3 had creatinine clearances ranging from 14.5 to 59 mL/min and 10 to 20 mL/min, respectively. Zonisamide renal clearance decreased with decreasing renal function (3.42, 2.50, 2.23 mL/min, respectively).

Marked renal impairment (creatinine clearance <20 mL/min) was associated with an increase in zonisamide AUC of 35%.

GRPH-general-zonisamide-01 · Source section: GlobalRPh general renal statementRenal section finder
Locally imported selected renal sections

GlobalRPh RX List renal information

Rxlist

GlobalRPh RX List - ZONEGRAN

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GlobalRPh-hosted RX List · Oral zonisamide capsules; renal restriction and toxicity surveillance.

Renal method: Estimated GFR, printed as mL/min; normalization not specified in this passage.
Source date: Source revision date not established in selected retrieval.
Retrieved: 2026-09-07

Label mirror, not independent corroboration. This is selected locally stored RX List content. Full monograph import and current official-label review are not implied.
Restriction or avoidance guidance. Read the specific threshold, age, formulation and dialysis exclusions; do not generalize across products.

Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.

Renal dosing, restrictions and evidence limits

The source advises against use when estimated GFR is below 50 mL/min because renal dosing and toxicity experience are insufficient. Its printed unit is mL/min, without an indexed denominator. Stop treatment if acute renal failure develops or creatinine/BUN rises persistently to a clinically significant extent. Renal surveillance is distinct from the separate metabolic-acidosis and stone precautions. Do not substitute a guessed lower dose for the source restriction.

RDM37-rxlist-general-zonisamide-2e0bbe9b29-C1 · Source locator: Precautions: Effect on Renal Function.

Source identity and provenance
Source family
product_label_mirror
Source
https://globalrph.com/rx-list/zonegran-drug/
Retrieved
2026-09-07
Renal-function method
Estimated GFR, printed as mL/min; normalization not specified in this passage.
Source date/version
Source revision date not established in selected retrieval.
Hash meaning
SHA-256 of local authored summary only; not original HTML, PDF or SPL bytes.
Local summary SHA-256
b9b6d5767ee5f05c6402f9673f610daf14d67ee9453886b2ce34abd3fd97cf6c

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 1 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://globalrph.com/renal/medications-with-general-renal-dosing-statements/
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
globalrph general · Numbered general entry 34
Local text SHA-256
b28874a8e88d2db653ad129705dc609b1fb41efadc874ab26412a848273cfd7a
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

The original individual GlobalRPh pages commonly cite NIH/NLM DailyMed and instruct readers to review the applicable package insert for updates. That historical reference is preserved as context; it is not counted as an independently retrieved current label.

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