GlobalRPh Renal Dosing Masterv6.6
GlobalRPh source record

Mirtazapine tablets

GlobalRPh general statementBase record retrieved 2026-09-05See the evidence for this drug1 sources available - open source summaries, references and comparisons
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GlobalRPh general renal statement

Renal Insufficiency: The disposition of mirtazapine was studied in patients with varying degrees of renal function. Elimination of mirtazapine is correlated with creatinine clearance.

Total body clearance of mirtazapine was reduced approximately 30% in patients with moderate (Clcr =11 to 39 mL/min/1.73 m2) and approximately 50% in patients with severe (Clcr <=10 mL/min/1.73 m2) renal impairment when compared to normal subjects. Caution is indicated in administering mirtazapine to patients with compromised renal function.

Dosing: Elderly and Patients with Renal or Hepatic Impairment: The clearance of mirtazapine is reduced in elderly patients and in patients with moderate to severe renal or hepatic impairment. Consequently, the prescriber should be aware that plasma mirtazapine levels may be increased in these patient groups, compared to levels observed in younger adults without renal or hepatic impairment.

Source revision: Historical source; revision not established here | Retrieved: 2026-09-05. Retrieval date is not the revision date.

Source: https://globalrph.com/renal/medications-with-general-renal-dosing-statements/

Scope: Preserved historical source; no fresh clinical approval GlobalRPh v6.6.

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Retrieved: 2026-09-05

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Original GlobalRPh protocol

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GlobalRPh general renal statement

Renal Insufficiency: The disposition of mirtazapine was studied in patients with varying degrees of renal function. Elimination of mirtazapine is correlated with creatinine clearance.

Total body clearance of mirtazapine was reduced approximately 30% in patients with moderate (Clcr =11 to 39 mL/min/1.73 m2) and approximately 50% in patients with severe (Clcr <=10 mL/min/1.73 m2) renal impairment when compared to normal subjects. Caution is indicated in administering mirtazapine to patients with compromised renal function.

Dosing: Elderly and Patients with Renal or Hepatic Impairment: The clearance of mirtazapine is reduced in elderly patients and in patients with moderate to severe renal or hepatic impairment. Consequently, the prescriber should be aware that plasma mirtazapine levels may be increased in these patient groups, compared to levels observed in younger adults without renal or hepatic impairment.

GRPH-general-mirtazapine-01 · Source section: GlobalRPh general renal statementRenal section finder

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Additional summaries stored on this page: 0 official-label, 0 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://globalrph.com/renal/medications-with-general-renal-dosing-statements/
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
globalrph general · Numbered general entry 16
Local text SHA-256
3232c6ff1a127e3cbd0c749f0f3a925ea4a56054219f276837af2694eec2e240
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The original individual GlobalRPh pages commonly cite NIH/NLM DailyMed and instruct readers to review the applicable package insert for updates. That historical reference is preserved as context; it is not counted as an independently retrieved current label.

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