GlobalRPh Renal Dosing Masterv7.4
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GlobalRPh source record

Canagliflozin - source Invokana/Invokamet statement

Read renal action and limits
Local official-label summarySource retrieved 2026-09-05See the evidence for this drug5 sources available - open source summaries, references and comparisons

Invokana

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Renal guidance at a glance

Cautions / source differences (1)

Use the renal measure and units named by this source. Confirm product, indication, age, stable versus changing kidney function, and exact dialysis modality. The selected summary is not a complete prescribing monograph. Renal method and dosing checklist

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Display order is not a clinical ranking. Date of retrieval is not the label revision date. Sources are never merged into one regimen. Other sources and conflicts remain below.

1 additional source qualifications - review before use
Invokana - product and source limitations

Use the prescribing information's separate UGT-inducer instructions when applicable. This continuation exception does not transfer to canagliflozin/metformin.

Before applying: Apply only to the stated formulation, indication and renal population.

Also check: Invokana - product and source limitations

Handbook source

Renal Drug Handbook, fifth edition

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Product / population
Historical 2019 reference; renal bands retain the book's own method labels.
Renal measure
Not specified; verify before use
Source revision
Not established
Retrieved
2026-09-05 (not the revision date)

This cross-check is for single-agent canagliflozin, not the mixed INVOKANA/INVOKAMET original statement.

Historical single-agent canagliflozin

The handbook retains normal dosing above GFR 60, limits established treatment to 100 mg daily in the 45-60 range, and advises against initiation below eGFR 60 and use below 45. It advises avoidance during the listed replacement modalities and describes canagliflozin as not dialysed. These older cutoffs do not replace the current INVOKANA label.

Source revision: Not established | Retrieved: 2026-09-05. Retrieval date is not the revision date.

Source:

Scope: Historical handbook facts locally summarized; not a current U.S. label or a modern CRRT protocol. GlobalRPh v7.4.

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Source-first renal review

Evidence sources and renal implications

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GlobalRPh RX List

Invokana - selected RX renal passage

Renal toxicity or monitoring. On-treatment injury and monitoring instructions are not a baseline renal-dose schedule.

Canagliflozin (Invokana), adult single-ingredient oral tablets

Renal method: Use the renal measure explicitly present in the RX passage.
Retrieved: 2026-11-07

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Source presence is not independent validation. A label mirror is not a second independent source; review the original reference and exact formulation.

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Source-specific review points

Invokana - product and source limitations

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Source differences and product cautions

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These are specific issues found during source review, not an automated judgment that one source is universally correct. A label mirror and its original label are not independent evidence.

Source scope / renal recommendation differences

Invokana - product and source limitations

Use the prescribing information's separate UGT-inducer instructions when applicable. This continuation exception does not transfer to canagliflozin/metformin.

How to use this: Apply only to the stated formulation, indication and renal population.

Invokana - labeled renal guidanceInvokana - selected RX renal passage

Selected renal passages reviewed; independent clinician adjudication pending.

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Renal dosing and precautions

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Independent clinical review is pending. These selected summaries are not an approved institutional dosing protocol. Confirm the exact product, the complete current source and local policy before use.
Handbook source

Renal Drug Handbook, fifth edition

Historical 2019 reference; renal bands retain the book's own method labels.

Method: Not stated in selected source.

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Original content / product scopeINVOKANA (canagliflozin) tabletsInvokana - labeled renal guidanceInvokana - selected RX renal passageRenal Drug Handbook, fifth edition
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Historical source content is not a current prescription. Original GlobalRPh recommendations are preserved, not automatically certified as current. Product-label and professional additions below are separately attributed. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.

Important source distinctions

Product mismatch in the original source: the heading says INVOKANA but the body describes INVOKAMET. The complete original statement is preserved; do not apply its combination-product instructions to single-agent canagliflozin.

Locally stored source content

Original GlobalRPh protocol

Clinical facts and comments transcribed into a structured reading format. Read the original source for its complete context: https://globalrph.com/renal/medications-with-general-renal-dosing-statements/

GlobalRPh general renal statement

Canagliflozin - INVOKANA: Recommended Dosage for Patients with Renal Impairment: Assess renal function before initiating INVOKAMET and periodically thereafter. Do not initiate or continue INVOKAMET in patients with serum creatinine levels greater than or equal to 1.5 mg/dL for males or 1.4 mg/dL for females.

In patients who meet these serum creatinine levels, do not initiate or continue INVOKAMET if eGFR is persistently less than 45 mL/min/1.73 m2. No dose adjustment of INVOKAMET is needed in patients with mild renal impairment (eGFR of 60 mL/min/1.73 m2 or greater). Limit the dose of INVOKAMET to canagliflozin 50 mg twice daily in patients with moderate renal impairment with an eGFR of 45 to less than 60 mL/min/1.73 m2.

GRPH-general-canagliflozin-01 · Source section: GlobalRPh general renal statementRenal section finder
Separate U.S. product-label layer

FDA / DailyMed dosing and renal information

Official

INVOKANA (canagliflozin) tablets

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NIH/NLM DailyMed - U.S. prescribing information · Adult oral single agent. Does not apply to INVOKAMET or INVOKAMET XR.

Renal method: Not specified in this summary.
Source date:
Retrieved: 2026-09-05

Source-read local summary; source-specific recommendations are not automatically interchangeable.

Usual dosing and renal adjustment

Start 100 mg once daily before the first meal. For additional glycemic control, patients tolerating 100 mg with eGFR >=60 mL/min/1.73 m2 may increase to 300 mg daily. At eGFR 30 to <60, the usual maximum is 100 mg daily. Below 30, initiation is not recommended; adults already taking it with albuminuria >300 mg/day may continue 100 mg for the labeled renal/cardiovascular benefit.

general-canagliflozin:dm-b9057d3b-b104-4f09-8a61-c61ef9d4a3f3-1 · Source locator: 2.2-2.3, Table 1

Interaction-specific exception

With a UGT inducer, the label permits an increase from tolerated 100 mg to 200 mg daily; the maximum is 300 mg at eGFR >=60 and 200 mg below 60. This is a distinct interaction regimen, not the ordinary renal table.

general-canagliflozin:dm-b9057d3b-b104-4f09-8a61-c61ef9d4a3f3-2 · Source locator: 2.4

Procedure interruption

Withhold at least 3 days before surgery or prolonged fasting when possible; resume when clinically stable and eating.

general-canagliflozin:dm-b9057d3b-b104-4f09-8a61-c61ef9d4a3f3-3 · Source locator: 2.5

Source identity and provenance
Source
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b9057d3b-b104-4f09-8a61-c61ef9d4a3f3
Retrieved
2026-09-05
Exact label title
INVOKANA (canagliflozin) tablets
DailyMed Set ID
b9057d3b-b104-4f09-8a61-c61ef9d4a3f3
Labeler
Janssen Pharmaceuticals, Inc.
DailyMed page updated
2026-06-11
FDA application
New Drug Application
U.S. product identity basis
Exact named product and route appear in the selected U.S. prescription label; current retail availability was not independently assessed.
Hash meaning
Locally authored source summary, not original SPL/XML/PDF bytes
Local summary SHA-256
ee69802d2cb64ae5e542a0ffdf7bd54902541fd5349853c6799e693e454deb3e
Official

Invokana - labeled renal guidance

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DailyMed / product prescribing information · Canagliflozin (Invokana), adult single-ingredient oral tablets

Renal method: Indexed GFR/eGFR, mL/min/1.73 m2
Source date: DailyMed SPL version 9, effective 2026-09-21; posted Sep 23, 2026
Retrieved: 2026-11-07

Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Selected renal passages reviewed; independent clinician adjudication pending.

Renal guidance: 2, renal impairment and interacting drugs

For adults with eGFR 30 to <60, the usual renal maximum is 100 mg once daily. Below 30, initiation is not recommended. Adults already taking it who have albuminuria >300 mg/day may continue 100 mg daily for the labeled cardiorenal indication. Use the prescribing information's separate UGT-inducer instructions when applicable. This continuation exception does not transfer to canagliflozin/metformin.

RDM73-invokana-official-1 · Source locator: Renal guidance: 2, renal impairment and interacting drugs

Source identity and provenance
Source family
product_label
Source
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4e946ba3-02c4-4a10-9d5e-f2d87b534dc3
Retrieved
2026-11-07
Renal-function method
Indexed GFR/eGFR, mL/min/1.73 m2
Source date/version
DailyMed SPL version 9, effective 2026-09-21; posted Sep 23, 2026
Hash meaning
SHA-256 of the local selected-source summary
Local summary SHA-256
d9b9912131383a1483adc39cc31ff84a20c8a2d76e50d2f31ac5c066d2cfafbd
Locally imported selected renal sections

GlobalRPh RX List renal information

Rxlist

Invokana - selected RX renal passage

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GlobalRPh RX List / product-label mirror · Canagliflozin (Invokana), adult single-ingredient oral tablets

Renal method: Use the renal measure explicitly present in the RX passage.
Source date: Mirror revision not established in the reviewed passage.
Retrieved: 2026-11-07

Label mirror, not independent corroboration. This is selected locally stored RX List content. Full monograph import and current official-label review are not implied.
Renal toxicity or monitoring. On-treatment injury and monitoring instructions are not a baseline renal-dose schedule.

Selected renal passages reviewed; independent clinician adjudication pending.

RX List: selected renal passage

The mirror describes greater susceptibility to hypotension and acute kidney injury in renal impairment.

RDM73-invokana-rxlist-1 · Source locator: RX List: selected renal passage

Source-specific limits

This mirror and the underlying product label share a source family.

Source identity and provenance
Source family
product_label_mirror
Source
https://globalrph.com/rx-list/invokana-drug/
Retrieved
2026-11-07
Renal-function method
Use the renal measure explicitly present in the RX passage.
Source date/version
Mirror revision not established in the reviewed passage.
Hash meaning
SHA-256 of the local selected-source summary
Local summary SHA-256
21f8e13984e71baa52a8dd500d7634f7f8414c541dd4f825d7f4eae65744ca97
Separate handbook layer

Renal Drug Handbook cross-check

Handbook

Renal Drug Handbook, fifth edition

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UK Renal Pharmacy Group / Ashley and Dunleavy / CRC Press · Historical 2019 reference; renal bands retain the book's own method labels.

Renal method: Not specified in this summary.
Source date: Not established
Retrieved: 2026-09-05

Historical handbook facts locally summarized; not a current U.S. label or a modern CRRT protocol.

Historical single-agent canagliflozin

The handbook retains normal dosing above GFR 60, limits established treatment to 100 mg daily in the 45-60 range, and advises against initiation below eGFR 60 and use below 45. It advises avoidance during the listed replacement modalities and describes canagliflozin as not dialysed. These older cutoffs do not replace the current INVOKANA label.

general-canagliflozin:rdh5-161-1 · Source locator: Renal impairment; renal replacement; Other information

Source-specific limits

This cross-check is for single-agent canagliflozin, not the mixed INVOKANA/INVOKAMET original statement.

Source identity and provenance
Retrieved
2026-09-05
Handbook page
Printed page 161; PDF page 180
Hash meaning
Locally authored source summary, not original SPL/XML/PDF bytes
Local summary SHA-256
d5fa508e1fd965b386c5d9045ed40def902ec160dc38cdbd5e86ec2b2247c497

Provenance and preservation

Additional summaries stored on this page: 2 official-label, 1 RX List, 0 professional, 1 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://globalrph.com/renal/medications-with-general-renal-dosing-statements/
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
globalrph general · Numbered general entry 5
Local text SHA-256
b3818a39dddd6a7a7227ff2a020937554389d5f29215023a2ba1117901369286
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

The original individual GlobalRPh pages commonly cite NIH/NLM DailyMed and instruct readers to review the applicable package insert for updates. That historical reference is preserved as context; it is not counted as an independently retrieved current label.

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