GlobalRPh Renal Dosing Masterv6.6
GlobalRPh source record

Ganciclovir

GlobalRPh source pageBase record retrieved 2026-09-05See the evidence for this drug2 sources available - open source summaries, references and comparisons
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Professional source

UCSF - intravenous ganciclovir

Product / population
Adults; source-specific institutional guidance. Match route, indication and renal replacement modality.
Renal measure
CrCl in mL/min where specified; no equation inferred.

Dosing / renal protocol and limits

Limits that apply to these rows

Exactly 70 is unassigned. Use total body weight unless >120% of ideal, then adjusted weight per this source. Continuous-flow changes require reassessment.

CMV treatment - IV
CrCl, mL/minSource-specific dose / instruction
>705 mg/kg every 12 hours
50-692.5 mg/kg every 12 hours
25-492.5 mg/kg every 24 hours
10-241.25 mg/kg every 24 hours
CMV prevention - IV
CrCl, mL/minSource-specific dose / instruction
>705 mg/kg every 24 hours
50-692.5 mg/kg every 24 hours
25-491.25 mg/kg every 24 hours
10-240.625 mg/kg every 24 hours
Dialysis guidance - separate source-specific schedules
Ganciclovir dialysis
Dialysis setting / indicationSource-specific schedule
IHD treatment1.25 mg/kg initially and after HD
IHD prevention0.625 mg/kg initially and after HD
Continuous HD treatment2.5 mg/kg every 12 hours
Continuous HD prevention2.5 mg/kg every 24 hours
Read the retained text before reformatting

CrCl bands: >70 / 50-69 / 25-49 / 10-24 mL/min. CMV treatment: 5 mg/kg every 12 hours / 2.5 mg/kg every 12 hours / 2.5 mg/kg daily / 1.25 mg/kg daily. Prevention: 5 / 2.5 / 1.25 / 0.625 mg/kg daily. Exactly 70 is not assigned in the displayed bands.

Intermittent-HD treatment: 1.25 mg/kg initially and after HD; prevention: 0.625 mg/kg initially and after HD. Continuous-HD treatment: 2.5 mg/kg every 12 hours; prevention: 2.5 mg/kg daily. Continuous-flow changes require individualized reassessment.

Use total body weight unless it exceeds 120% of ideal body weight, when the source uses adjusted weight. All doses here are IV.

Source revision: Revision date not stated in the reviewed page. | Retrieved: 2026-09-05. Retrieval date is not the revision date.

Source: https://idmp.ucsf.edu/content/ganciclovir

Scope: Locally included source-specific summary. Regimen differences are not automatically resolved. GlobalRPh v6.6.

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Source-first renal review

Evidence sources and renal implications

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Preserved GlobalRPh source

Preserved original GlobalRPh source

Preserved historical content; not revalidated as current prescribing guidance.

Renal method: Read the measure and population stated in the original source sections.
Retrieved: 2026-09-05

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Professional guidance

UCSF - intravenous ganciclovir

Adults; source-specific institutional guidance. Match route, indication and renal replacement modality.

Renal method: CrCl in mL/min where specified; no equation inferred.
Retrieved: 2026-09-05

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Renal dosing and precautions

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Original content / product scopeUCSF - intravenous ganciclovir
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Historical source content is not a current prescription. Original GlobalRPh recommendations are preserved, not automatically certified as current. Product-label and professional additions below are separately attributed. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.

Important source distinctions

Original oral ganciclovir schedules are not oral valganciclovir schedules. The source grouping of HD and PD is preserved and flagged for modality-specific revalidation.

Locally stored source content

Original GlobalRPh protocol

Clinical facts and comments transcribed into a structured reading format. This is not a byte-for-byte HTML archive. Original source: https://globalrph.com/renal/ganciclovir/

Usual Dosing (Adults)

CMV retinitis source summary: IV induction 5 mg/kg every 12 hours for 14 to 21 days; maintenance 5 mg/kg every 24 hours. Oral ganciclovir: 1 g every 8 hours or 500 mg every 3 hours (six doses/day), with food.

Do not give CYTOVENE-IV rapidly or as IV bolus: excessive levels increase toxicity. IM/subcutaneous injection of reconstituted pH 11 solution can cause severe tissue irritation. Do not exceed recommended dose or infusion rate.

Retinitis with normal renal function: induction 5 mg/kg IV at constant rate over 1 hour every 12 hours for 14 to 21 days. Maintenance 5 mg/kg over 1 hour daily seven days/week or 6 mg/kg daily five days/week. Reinduction is recommended for progression during maintenance.

Transplant CMV prevention, normal function: 5 mg/kg IV over 1 hour every 12 hours for 7 to 14 days, then 5 mg/kg daily seven days/week or 6 mg/kg daily five days/week. Duration depends on degree/duration of immunosuppression. Bone-marrow allograft trials continued to days 100 to 120; several patients stopping early developed CMV. Heart allograft patients developed new CMV after therapy stopped on day 28, suggesting need for continued dosing to prevent late disease.

GRPH-ganciclovir-01 · Source section: Usual Dosing (Adults)Renal section finder

Renal Dosing

CrCl (mL/min)IV inductionIV maintenanceOral ganciclovir
>70No changeNo changeNo change
50 to 692.5 mg/kg every 12 hours2.5 mg/kg every 24 hours1500 mg daily or 500 mg three times daily
25 to 492.5 mg/kg every 24 hours1.25 mg/kg every 24 hours1000 mg daily or 500 mg twice daily
10 to 241.25 mg/kg every 24 hours0.625 mg/kg every 24 hours500 mg daily
<101.25 mg/kg three times/week after dialysis0.625 mg/kg three times/week after dialysis500 mg three times/week after dialysis
GRPH-ganciclovir-02 · Source section: Renal DosingRenal section finder

Hemodialysis

The source groups hemodialysis and peritoneal dialysis together: IV induction 1.25 mg/kg three times/week following dialysis; IV maintenance 0.625 mg/kg three times/week following dialysis; oral 500 mg three times/week following dialysis.

GRPH-ganciclovir-03 · Source section: HemodialysisRenal section finder
Separate professional-source layer

University and professional protocols

Professional

UCSF - intravenous ganciclovir

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UCSF Infectious Diseases Management Program · Adults; source-specific institutional guidance. Match route, indication and renal replacement modality.

Renal method: CrCl in mL/min where specified; no equation inferred.
Source date: Revision date not stated in the reviewed page.
Retrieved: 2026-09-05

Locally included source-specific summary. Regimen differences are not automatically resolved.

Dosing / renal protocol and limits

Limits that apply to these rows

Exactly 70 is unassigned. Use total body weight unless >120% of ideal, then adjusted weight per this source. Continuous-flow changes require reassessment.

CMV treatment - IV
CrCl, mL/minSource-specific dose / instruction
>705 mg/kg every 12 hours
50-692.5 mg/kg every 12 hours
25-492.5 mg/kg every 24 hours
10-241.25 mg/kg every 24 hours
CMV prevention - IV
CrCl, mL/minSource-specific dose / instruction
>705 mg/kg every 24 hours
50-692.5 mg/kg every 24 hours
25-491.25 mg/kg every 24 hours
10-240.625 mg/kg every 24 hours
Dialysis guidance - separate source-specific schedules
Ganciclovir dialysis
Dialysis setting / indicationSource-specific schedule
IHD treatment1.25 mg/kg initially and after HD
IHD prevention0.625 mg/kg initially and after HD
Continuous HD treatment2.5 mg/kg every 12 hours
Continuous HD prevention2.5 mg/kg every 24 hours
Read the retained text before reformatting

CrCl bands: >70 / 50-69 / 25-49 / 10-24 mL/min. CMV treatment: 5 mg/kg every 12 hours / 2.5 mg/kg every 12 hours / 2.5 mg/kg daily / 1.25 mg/kg daily. Prevention: 5 / 2.5 / 1.25 / 0.625 mg/kg daily. Exactly 70 is not assigned in the displayed bands.

Intermittent-HD treatment: 1.25 mg/kg initially and after HD; prevention: 0.625 mg/kg initially and after HD. Continuous-HD treatment: 2.5 mg/kg every 12 hours; prevention: 2.5 mg/kg daily. Continuous-flow changes require individualized reassessment.

Use total body weight unless it exceeds 120% of ideal body weight, when the source uses adjusted weight. All doses here are IV.

RDM30-027-ganciclovir-1 · Source locator: UCSF - intravenous ganciclovir; renal/dosing sections and stated qualifiers

Source identity and provenance
Source
https://idmp.ucsf.edu/content/ganciclovir
Retrieved
2026-09-05
Renal-function method
CrCl in mL/min where specified; no equation inferred.
Source date/version
Revision date not stated in the reviewed page.
Hash meaning
Locally authored summary text; not original SPL, HTML or PDF bytes
Local summary SHA-256
5c806946aa388e15640aabb9656efa0dd16e11727cd07a9f8fcff2a822d3a96e

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 0 RX List, 1 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://globalrph.com/renal/ganciclovir/
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
globalrph individual
Local text SHA-256
0dd11291676c4a8f22d11e3061e702f3bc5d417cfc4e5b62289aacd88a462724
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

The original individual GlobalRPh pages commonly cite NIH/NLM DailyMed and instruct readers to review the applicable package insert for updates. That historical reference is preserved as context; it is not counted as an independently retrieved current label.

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