GlobalRPh RX List - Gadoteridol (ProHance Multipack)
- Product / population
- PROHANCE MULTIPACK intravenous MRI contrast; bulk container is not a different renal clearance rule.
- Renal measure
- Indexed GFR (mL/min/1.73 m2) and acute kidney injury.
RX mirror: this is not independent corroboration of its underlying label. Check dated-label and formulation limitations.
Renal dosing, restrictions and evidence limits
The warning identifies acute kidney injury and GFR below 30 as highest-risk settings for NSF and advises avoiding exposure unless essential information cannot be obtained through alternatives. Screen renal risk, do not exceed the recommended dose, and permit clearance before another exposure. Elimination is prolonged with renal impairment. Prompt dialysis can be considered for patients already on hemodialysis, but its effectiveness in preventing NSF is unknown. No new renal dose-reduction algorithm is derived from the pharmacokinetic observations.
Source: https://globalrph.com/rx-list/prohance-multipack-drug/