Gabapentin enacarbil extended-release (Horizant)

Take with food at about 5 PM. Cockcroft-Gault CrCl (mL/min): >=60, 600 mg daily; 30-59, start 300 mg daily and increase to 600 mg if needed; 15-29, 300 mg daily; <15, 300 mg every other day. RLS treatment is not recommended on HD.

At CrCl >=60: 600 mg each morning for 3 days, then twice daily. At 30-59: 300 mg each morning for 3 days, then twice daily; may increase to 600 mg twice daily. At 15-29: 300 mg on days 1 and 3, then every morning; may increase to twice daily. Below 15 without HD: 300 mg every other morning, increasing to daily if needed. On HD: 300 mg after each session, increasing to 600 mg if needed.

When stopping PHN twice-daily treatment, reduce to once daily for one week. Swallow whole. HORIZANT is not substitutable with other gabapentin products.

RLS: at least 60, 600 mg once daily around 5 PM; 30-59, start 300 mg daily and increase to 600 mg if needed; 15-29, 300 mg daily; below 15, 300 mg every other day. RLS use during hemodialysis is not recommended.

PHN maintenance after indication-specific titration: at least 60, 600 mg twice daily; 30-59, 300 mg twice daily, potentially 600 mg twice daily; 15-29, 300 mg each morning, potentially twice daily; below 15 without dialysis, 300 mg every other morning, potentially daily. On hemodialysis, 300 mg after each dialysis, potentially 600 mg if needed and tolerated. Consult the separate PHN titration and discontinuation instructions; these maintenance schedules are not starting-dose instructions.

Adult restless legs syndrome: CrCl >=60 mL/min, 600 mg daily; 30-59, start 300 mg daily and increase to 600 mg if needed; 15-29, 300 mg daily; <15, 300 mg every other day. For hemodialysis patients, use for RLS is not recommended.

Adult postherpetic neuralgia: the renal table instead permits 300 mg after each dialysis, increasing to 600 mg if needed. Non-dialysis PHN maintenance is 600 mg twice daily at >=60; 300 mg twice daily at 30-59 (may increase to 600 mg twice daily); 300 mg each morning at 15-29 (may increase to twice daily); and 300 mg every other morning at <15 (may increase to daily). PHN has separate titration and discontinuation instructions: consult the complete table before starting or stopping.

Take this extended-release product with food and swallow whole. These instructions are not interchangeable with other gabapentin products.