GlobalRPh Renal Dosing Masterv6.6
GlobalRPh source record

Flucytosine

Local RX List renal extractBase record retrieved 2026-09-05See the evidence for this drug5 sources available - open source summaries, references and comparisons
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Renal guidance at a glance

Cautions / source differences (1)

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1 additional source qualifications - review before use
Qualitative label versus institutional intervals; exactly 20 overlaps

ANCOBON emphasizes concentration-guided adjustment without a renal interval table. UCSF supplies intervals, but its printed 20-40 and 10-20 bands both include 20.

Before applying: Clarify the boundary and dosing weight with ID/pharmacy; retain serum-level and toxicity monitoring.

Also check: Qualitative label versus institutional intervals; exactly 20 overlaps

Rxlist source

GlobalRPh RX List - ANCOBON

Product / population
Oral flucytosine; renal-toxicity and concentration-monitoring section.
Renal measure
Renal impairment without a numerical interval table in the selected label section.

RX mirror: this is not independent corroboration of its underlying label. Check dated-label and formulation limitations.

Renal dosing, restrictions and evidence limits

Use with extreme caution in renal impairment. Monitor serum concentrations and adjust the dose to prevent accumulation; repeatedly assess renal function, hematologic indices and hepatic function. Obtain baseline electrolytes and hematologic/renal measures. The retrieved warning provides no renal-band interval table; the separately attributed institutional schedule must not be presented as wording from this label.

Source revision: Source revision date not established in selected retrieval. | Retrieved: 2026-09-07. Retrieval date is not the revision date.

Source: https://globalrph.com/rx-list/ancobon-drug/

Scope: Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph. GlobalRPh v6.6.

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Evidence sources and renal implications

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Preserved GlobalRPh source

Preserved original GlobalRPh source

Preserved historical content; not revalidated as current prescribing guidance.

Renal method: Read the measure and population stated in the original source sections.
Retrieved: 2026-09-05

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GlobalRPh RX List

GlobalRPh RX List - ANCOBON

Renal toxicity or monitoring. On-treatment injury and monitoring instructions are not a baseline renal-dose schedule.

Oral flucytosine; renal-toxicity and concentration-monitoring section.

Renal method: Renal impairment without a numerical interval table in the selected label section.
Retrieved: 2026-09-07

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Professional guidance

UCSF - flucytosine

Adults; source-specific institutional guidance. Match route, indication and renal replacement modality.

Renal method: CrCl in mL/min where specified; no equation inferred.
Retrieved: 2026-09-05

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Professional guidance

UCSF flucytosine - adult institutional renal schedules

Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Adult oral flucytosine institutional schedule; concentration and toxicity monitoring remain necessary.

Renal method: CrCl mL/min; intermittent HD separate; continuous-HD data absent.
Retrieved: 2026-09-07

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Source differences and product cautions

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threshold ambiguity

Qualitative label versus institutional intervals; exactly 20 overlaps

ANCOBON emphasizes concentration-guided adjustment without a renal interval table. UCSF supplies intervals, but its printed 20-40 and 10-20 bands both include 20.

How to use this: Clarify the boundary and dosing weight with ID/pharmacy; retain serum-level and toxicity monitoring.

GlobalRPh RX List - ANCOBONUCSF flucytosine - adult institutional renal schedules

Source-specific interpretation; independent clinician adjudication pending.

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Renal dosing and precautions

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New source summary - independent clinical review pending. Summaries of the identified label sections are included locally. Source import and numeric transcription checks are not independent two-reference validation. Do not treat this card as an approved institutional dosing protocol.

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Original content / product scopeGlobalRPh RX List - ANCOBONNIH OI: FlucytosineUCSF - flucytosineUCSF flucytosine - adult institutional renal schedules
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Historical source content is not a current prescription. Original GlobalRPh recommendations are preserved, not automatically certified as current. Product-label and professional additions below are separately attributed. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.
Locally stored source content

Original GlobalRPh protocol

Clinical facts and comments transcribed into a structured reading format. This is not a byte-for-byte HTML archive. Original source: https://globalrph.com/renal/flucytosine/

Usual Dosing (Adults)

Indicated only for serious infections due to susceptible Candida and/or Cryptococcus. Usual 50 to 150 mg/kg/day in divided doses every 6 hours. Taking capsules a few at a time over 15 minutes may lessen nausea/vomiting. If BUN/creatinine is elevated or renal impairment is otherwise evident, start at the lower dose level. Use with amphotericin B for systemic candidiasis and cryptococcosis because resistance emerges to flucytosine.

GRPH-flucytosine-01 · Source section: Usual Dosing (Adults)Renal section finder

Renal Dosing

CrCl >40 mL/min: no change; 20 to 40: 12.5 to 37.5 mg/kg every 12 hours; 10 to 20: 12.5 to 37.5 mg/kg every 24 hours; <10: 12.5 to 37.5 mg/kg every 24 to 48 hours.

GRPH-flucytosine-02 · Source section: Renal DosingRenal section finder

Hemodialysis

Usual per-dose amount (12.5 to 37.5 mg/kg) after each dialysis.

GRPH-flucytosine-03 · Source section: HemodialysisRenal section finder
Locally imported selected renal sections

GlobalRPh RX List renal information

Rxlist

GlobalRPh RX List - ANCOBON

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GlobalRPh-hosted RX List · Oral flucytosine; renal-toxicity and concentration-monitoring section.

Renal method: Renal impairment without a numerical interval table in the selected label section.
Source date: Source revision date not established in selected retrieval.
Retrieved: 2026-09-07

Label mirror, not independent corroboration. This is selected locally stored RX List content. Full monograph import and current official-label review are not implied.
Renal toxicity or monitoring. On-treatment injury and monitoring instructions are not a baseline renal-dose schedule.

Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.

Renal dosing, restrictions and evidence limits

Use with extreme caution in renal impairment. Monitor serum concentrations and adjust the dose to prevent accumulation; repeatedly assess renal function, hematologic indices and hepatic function. Obtain baseline electrolytes and hematologic/renal measures. The retrieved warning provides no renal-band interval table; the separately attributed institutional schedule must not be presented as wording from this label.

RDM41-rxlist-flucytosine-161bddf908-C1 · Source locator: Dosage / Use in specific populations: renal impairment

Source identity and provenance
Source family
product_label_mirror
Source
https://globalrph.com/rx-list/ancobon-drug/
Retrieved
2026-09-07
Renal-function method
Renal impairment without a numerical interval table in the selected label section.
Source date/version
Source revision date not established in selected retrieval.
Hash meaning
SHA-256 of local authored summary only; not original HTML, PDF or SPL bytes.
Local summary SHA-256
59320e21a16ae5b33dad877732d4e6b7fa90096d01d6a63c42bc6bbd6381cb14
Separate professional-source layer

University and professional protocols

Professional

NIH OI: Flucytosine

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NIH ClinicalInfo · Adults with HIV.

Renal method: NIH table: CrCl or eGFR; not interchangeable. Not CRRT.
Source date: Updated April 23, 2025; reviewed March 16, 2026
Retrieved: 2026-09-05

Source-read local summary; source-specific recommendations are not automatically interchangeable.

Dose and kidney adjustment

Usual: 25 mg/kg orally every 6 hours. Renal estimate 21-40 / 10-20 / <10 mL/min: 25 mg/kg every 12 / 24 / 48 hours. Intermittent HD: 25-50 mg/kg every 48-72 hours after HD. Target two-hour peak: 25-100 mcg/mL; without drug-level monitoring, check CBC twice weekly.

flucytosine:nih-oi-flucytosine-1 · Source locator: Table 6: Flucytosine row

Source identity and provenance
Source
https://clinicalinfo.hiv.gov/en/guidelines/hiv-clinical-guidelines-adult-and-adolescent-opportunistic-infections/dosing-recommendations-drugs-used
Retrieved
2026-09-05
Renal-function method
NIH table: CrCl or eGFR; not interchangeable. Not CRRT.
Source date/version
Updated April 23, 2025; reviewed March 16, 2026
Hash meaning
Locally authored source summary, not original SPL/XML/PDF bytes
Local summary SHA-256
c57b48419d0a83f2de3db7d42e99d31992e901c91dc37acefd31863eab6dbff1
Professional

UCSF - flucytosine

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UCSF Infectious Diseases Management Program · Adults; source-specific institutional guidance. Match route, indication and renal replacement modality.

Renal method: CrCl in mL/min where specified; no equation inferred.
Source date: Revision date not stated in the reviewed page.
Retrieved: 2026-09-05

Locally included source-specific summary. Regimen differences are not automatically resolved.

Dosing / renal protocol and limits

The dose is 25 mg/kg orally at intervals determined by CrCl: >40 mL/min every 6 hours; 20-40 every 12 hours; 10-20 every 24 hours; <10 every 48 hours. The printed bands overlap at 20; clarify that endpoint rather than choosing silently.

Intermittent HD: 25 mg/kg initially and after HD. Continuous-HD dosing is not supplied; consult infectious diseases. Discuss single doses above 2000 mg with ID pharmacy.

UCSF uses ideal body weight unless actual weight is lower, and adjusted weight when actual weight exceeds 120% of ideal. Drug-level and toxicity monitoring are important when individualizing therapy.

RDM30-028-flucytosine-1 · Source locator: UCSF - flucytosine; renal/dosing sections and stated qualifiers

Source identity and provenance
Source
https://idmp.ucsf.edu/content/flucytosine
Retrieved
2026-09-05
Renal-function method
CrCl in mL/min where specified; no equation inferred.
Source date/version
Revision date not stated in the reviewed page.
Hash meaning
Locally authored summary text; not original SPL, HTML or PDF bytes
Local summary SHA-256
f9854b3b3d7ee586d277cc7430b52bf398ebbce738984b15134c7010fab037ea
Professional

UCSF flucytosine - adult institutional renal schedules

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UCSF Infectious Diseases Management Program · Adult oral flucytosine institutional schedule; concentration and toxicity monitoring remain necessary.

Renal method: CrCl mL/min; intermittent HD separate; continuous-HD data absent.
Source date: Source revision date not established in selected retrieval.
Retrieved: 2026-09-07

Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.

Renal dosing, restrictions and evidence limits

Use 25 mg/kg orally every 6 hours at CrCl >40; every 12 hours at 20-40; every 24 hours at 10-20; every 48 hours below 10. The printed ranges overlap at exactly 20: obtain clarification rather than rounding or choosing silently.

Intermittent HD: 25 mg/kg once now and after HD. Continuous HD: no data; consult ID pharmacy. The page lists ideal body weight, total weight if below ideal, and adjusted weight if >120% of ideal. Discuss doses exceeding 2000 mg with ID/antimicrobial stewardship.

RDM41-professional-flucytosine-fa7d6cbc56-C1 · Source locator: Dosing weights; adult renal/dialysis tables; dose consultation note

Source identity and provenance
Source family
professional_guidance
Source
https://idmp.ucsf.edu/content/flucytosine
Retrieved
2026-09-07
Renal-function method
CrCl mL/min; intermittent HD separate; continuous-HD data absent.
Source date/version
Source revision date not established in selected retrieval.
Hash meaning
SHA-256 of local authored summary only; not original HTML, PDF or SPL bytes.
Local summary SHA-256
3d4a0125d77c2410ef3db76eae3609144d8303ea7ef0cbf0f99267f9dddd7b45

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 1 RX List, 3 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://globalrph.com/renal/flucytosine/
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
globalrph individual
Local text SHA-256
cc6e0edaf9202990c3209300e50462346f9df798b4a24cc0cd4e86a28453f249
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

The original individual GlobalRPh pages commonly cite NIH/NLM DailyMed and instruct readers to review the applicable package insert for updates. That historical reference is preserved as context; it is not counted as an independently retrieved current label.

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