GlobalRPh Renal Dosing Masterv6.6
Evidence addition

Fidaxomicin (Dificid)

Local official-label summaryBase record retrieved 2026-09-05See the evidence for this drug3 sources available - open source summaries, references and comparisons

Dificid

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Official source

DIFICID - adult oral C. difficile regimen

Product / population
Adults; named product and route only. Selected dosing and renal summary, not the full prescribing information.
Renal measure
No renal-function dose bands specified for this summary.

Dosing / renal protocol and limits

Adult C. difficile-associated diarrhea: 200 mg orally twice daily for 10 days, with or without food. No dose adjustment is recommended based on renal function, including the severe-impairment category studied (CrCl <=30 mL/min). The label does not provide a distinct dialysis replacement dose.

This is an oral intestinal-infection regimen, not treatment of systemic infection. Do not substitute the pediatric suspension volume table without confirming age, weight and concentration.

Source revision: DailyMed updated 2024-10-16. | Retrieved: 2026-09-05. Retrieval date is not the revision date.

Source: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=dd966338-c820-4270-b704-09ef75fa3ceb

Scope: Locally included source-specific summary. Regimen differences are not automatically resolved. GlobalRPh v6.6.

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Source-first renal review

Evidence sources and renal implications

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Official product label

DIFICID - adult oral C. difficile regimen

Adults; named product and route only. Selected dosing and renal summary, not the full prescribing information.

Renal method: No renal-function dose bands specified for this summary.
Retrieved: 2026-09-05

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Professional guidance

UCSF - fidaxomicin for C. difficile

Adults; source-specific institutional guidance. Match route, indication and renal replacement modality.

Renal method: Qualitative no-adjustment guidance.
Retrieved: 2026-09-05

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Handbook

Renal Drug Handbook, 5th edition - Fidaxomicin

Historical adult renal/RRT summary. U.S. product identity anchored to the separate locally included DailyMed label. This is not a current U.S. product label.

Renal method: Book table headed GFR (mL/min); its preface states renal adjustments generally derive from Cockcroft-Gault CrCl. Do not silently relabel as indexed eGFR.
Retrieved: 2026-09-05

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Renal-context checklist: population, kidney trend and dialysis

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Renal dosing and precautions

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Handbook source

Renal Drug Handbook, 5th edition - Fidaxomicin

Historical adult renal/RRT summary. U.S. product identity anchored to the separate locally included DailyMed label. This is not a current U.S. product label.

Method: Book table headed GFR (mL/min); its preface states renal adjustments generally derive from Cockcroft-Gault CrCl. Do not silently relabel as indexed eGFR.

Historical renal / replacement-therapy guidanceRead this complete source summary

No dialysis or renal heading shown? Read the complete source summary. Absence of a heading is not evidence that dose adjustment is unnecessary.

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Original content / product scopeDIFICID - adult oral C. difficile regimenUCSF - fidaxomicin for C. difficileRenal Drug Handbook, 5th edition - Fidaxomicin
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Exact product and population matter. This added page contains locally stored, source-specific clinical summaries. Historical handbook information, when present, is identified separately and may conflict with U.S. labeling. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.
Locally stored source content

Exact product and population

Product identity selected for the separately displayed source protocols below. Reference: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=dd966338-c820-4270-b704-09ef75fa3ceb

Product and population scope

Adult Fidaxomicin (Dificid). Use only the product, route, indication and renal-replacement setting explicitly stated in the source protocol selected below. Sources are alternatives to compare, not ingredients of a blended regimen.

SCOPE-fidaxomicin · Source section: Editorial scope; each clinical recommendation is separately attributed belowRenal section finder
Separate U.S. product-label layer

FDA / DailyMed dosing and renal information

Official

DIFICID - adult oral C. difficile regimen

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NIH/NLM DailyMed - U.S. product labeling · Adults; named product and route only. Selected dosing and renal summary, not the full prescribing information.

Renal method: No renal-function dose bands specified for this summary.
Source date: DailyMed updated 2024-10-16.
Retrieved: 2026-09-05

Locally included source-specific summary. Regimen differences are not automatically resolved.

Dosing / renal protocol and limits

Adult C. difficile-associated diarrhea: 200 mg orally twice daily for 10 days, with or without food. No dose adjustment is recommended based on renal function, including the severe-impairment category studied (CrCl <=30 mL/min). The label does not provide a distinct dialysis replacement dose.

This is an oral intestinal-infection regimen, not treatment of systemic infection. Do not substitute the pediatric suspension volume table without confirming age, weight and concentration.

RDM30-074-fidaxomicin-1 · Source locator: DIFICID - adult oral C. difficile regimen; renal/dosing sections and stated qualifiers

Source identity and provenance
Source
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=dd966338-c820-4270-b704-09ef75fa3ceb
Retrieved
2026-09-05
DailyMed Set ID
dd966338-c820-4270-b704-09ef75fa3ceb
Renal-function method
No renal-function dose bands specified for this summary.
Source date/version
DailyMed updated 2024-10-16.
Hash meaning
Locally authored summary text; not original SPL, HTML or PDF bytes
Local summary SHA-256
60e1804dd4a81741e3cb45c08921a6dcbc8d61b0b0f4b6a61f0c1cd34f24dc45
Separate handbook layer

Renal Drug Handbook cross-check

Handbook

Renal Drug Handbook, 5th edition - Fidaxomicin

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UK Renal Pharmacy Group / CRC Press · Historical adult renal/RRT summary. U.S. product identity anchored to the separate locally included DailyMed label. This is not a current U.S. product label.

Renal method: Book table headed GFR (mL/min); its preface states renal adjustments generally derive from Cockcroft-Gault CrCl. Do not silently relabel as indexed eGFR.
Source date: 5th edition; 2019 copyright; historical reference
Retrieved: 2026-09-05

Historical handbook cross-check; not a current U.S. protocol

Historical renal / replacement-therapy guidance

The 20-50, 10-20 and <10 mL/min bands retain the usual indication-specific dose. The <10 band adds caution. The adult C. difficile regimen is 200 mg twice daily for 10 days. PD, HD, high-flux and continuous therapy retain usual dosing; removal is considered unlikely. The book notes older UK caution below 30 because of limited data, while its renal dose recommendation draws on U.S. information.

HB30-fidaxomicin-1 · Source locator: Printed page 427: renal impairment, RRT and other information

Source-specific limits

Separate source recommendation, not proof of agreement or contemporary clinical validation. Dialysis predictions are retained with their original certainty.

Source identity and provenance
Retrieved
2026-09-05
Handbook page
5th edition, printed p. 427; uploaded PDF p. 446
Renal-function method
Book table headed GFR (mL/min); its preface states renal adjustments generally derive from Cockcroft-Gault CrCl. Do not silently relabel as indexed eGFR.
Source date/version
5th edition; 2019 copyright; historical reference
U.S. product identity basis
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=dd966338-c820-4270-b704-09ef75fa3ceb
Hash meaning
Local paraphrase; original book not redistributed
Local summary SHA-256
33a9ef416663fd83a8ac7aa9f9b7ec0408af7f9d1f1311397974bc621d6bb072
Separate professional-source layer

University and professional protocols

Professional

UCSF - fidaxomicin for C. difficile

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UCSF Infectious Diseases Management Program · Adults; source-specific institutional guidance. Match route, indication and renal replacement modality.

Renal method: Qualitative no-adjustment guidance.
Source date: Revision date not stated in the reviewed page.
Retrieved: 2026-09-05

Locally included source-specific summary. Regimen differences are not automatically resolved.

Dosing / renal protocol and limits

For adult C. difficile infection, the dose is 200 mg orally every 12 hours. UCSF retains this schedule in renal dysfunction and hemodialysis. Select the CDI treatment course under the applicable infection guideline; this is not systemic antibacterial treatment.

RDM30-038-fidaxomicin-1 · Source locator: UCSF - fidaxomicin for C. difficile; renal/dosing sections and stated qualifiers

Source identity and provenance
Source
https://idmp.ucsf.edu/content/fidaxomicin
Retrieved
2026-09-05
Renal-function method
Qualitative no-adjustment guidance.
Source date/version
Revision date not stated in the reviewed page.
Hash meaning
Locally authored summary text; not original SPL, HTML or PDF bytes
Local summary SHA-256
02e296a3639e6220447c3ccc7c88794835e67fd882ff184b2156da46300070cb

Provenance and preservation

Additional summaries stored on this page: 1 official-label, 0 RX List, 1 professional, 1 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=dd966338-c820-4270-b704-09ef75fa3ceb
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
multisource addition
Local text SHA-256
b896e9734d5499c0e4bcade616f9f8e8e9b0242f6b71f76b0ad9af334ec4ea80
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

This page is an additional exact-product entry, not a recovered GlobalRPh monograph. Its primary scope text and separately attributed clinical summaries are locally included.

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