GlobalRPh Renal Dosing Masterv6.6
Evidence addition

Fedratinib capsules (INREBIC)

Local RX List renal extractBase record retrieved 2026-09-07See the evidence for this drug2 sources available - open source summaries, references and comparisons

INREBIC

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Renal guidance at a glance

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Rxlist source

GlobalRPh RX List - INREBIC

Product / population
Adult oral fedratinib for labeled myelofibrosis; selected renal dose and monitoring.
Renal measure
Cockcroft-Gault CrCl in mL/min.

RX mirror: this is not independent corroboration of its underlying label. Check dated-label and formulation limitations.

Renal dosing, restrictions and evidence limits

At CrCl 15-29 mL/min, reduce to 200 mg orally once daily. No renal starting-dose change is recommended at CrCl 30-89, but moderate impairment requires more intensive adverse-effect monitoring and later toxicity-based changes when needed. Baseline and ongoing thiamine, blood counts, kidney/liver tests and pancreatic enzymes remain relevant. No regimen is extrapolated below 15 mL/min or to dialysis from these bands.

Source revision: Source revision date not established in selected retrieval. | Retrieved: 2026-09-07. Retrieval date is not the revision date.

Source: https://globalrph.com/rx-list/inrebic-drug/

Scope: Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph. GlobalRPh v6.6.

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Source-first renal review

Evidence sources and renal implications

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GlobalRPh RX List

GlobalRPh RX List - INREBIC

Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Oral fedratinib; renal modification must be reconciled with other treatment-specific adjustments.

Renal method: Cockcroft-Gault CrCl in mL/min.
Retrieved: 2026-09-07

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GlobalRPh RX List

GlobalRPh RX List - INREBIC

Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Adult oral fedratinib for labeled myelofibrosis; selected renal dose and monitoring.

Renal method: Cockcroft-Gault CrCl in mL/min.
Retrieved: 2026-09-07

Read local renal resultOpen original reference

Source presence is not independent validation. A label mirror is not a second independent source; review the original reference and exact formulation.

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Renal-context checklist: population, kidney trend and dialysis

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See source-specific renal methods and the clinical interpretation guide for the supporting context.

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Renal dosing and precautions

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New source summary - independent clinical review pending. Summaries of the identified label sections are included locally. Source import and numeric transcription checks are not independent two-reference validation. Do not treat this card as an approved institutional dosing protocol.

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Original content / product scopeGlobalRPh RX List - INREBICGlobalRPh RX List - INREBIC
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Exact product and population matter. This added page contains locally stored, source-specific clinical summaries. Historical handbook information, when present, is identified separately and may conflict with U.S. labeling. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.
Locally stored source content

Exact product and population

Product identity selected for the separately displayed source protocols below. Reference: https://globalrph.com/rx-list/inrebic-drug/

Exact product and population

Oral fedratinib; renal modification must be reconciled with other treatment-specific adjustments.

RDM41-SCOPE-fedratinib-inrebic · Source section: Selected source product scopeRenal section finder
Locally imported selected renal sections

GlobalRPh RX List renal information

Rxlist

GlobalRPh RX List - INREBIC

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GlobalRPh-hosted RX List · Oral fedratinib; renal modification must be reconciled with other treatment-specific adjustments.

Renal method: Cockcroft-Gault CrCl in mL/min.
Source date: May 2025
Retrieved: 2026-09-07

Label mirror, not independent corroboration. This is selected locally stored RX List content. Full monograph import and current official-label review are not implied.
Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.

Renal dosing, restrictions and evidence limits

CrCl 15-29 mL/min: reduce to 200 mg orally once daily. No starting-dose change is recommended for CrCl 30-89 mL/min; patients in the moderate range require closer safety monitoring and dose modification for adverse reactions. No ESRD regimen is established by these selected sections. A renal reduction and an interaction-related reduction are not automatically cumulative.

RDM41-rxlist-fedratinib-inrebic-2faea421ae-C1 · Source locator: Dosage / Use in specific populations: renal impairment

Source identity and provenance
Source family
product_label_mirror
Source
https://globalrph.com/rx-list/inrebic-drug/
Retrieved
2026-09-07
Renal-function method
Cockcroft-Gault CrCl in mL/min.
Source date/version
May 2025
Hash meaning
SHA-256 of local authored summary only; not original HTML, PDF or SPL bytes.
Local summary SHA-256
039b32cd65419e75f37c9dd367274a360351f8a757a2a3ffbd56d43521b8a65f
Rxlist

GlobalRPh RX List - INREBIC

Open original reference

Open / share this exact local source

GlobalRPh-hosted RX List · Adult oral fedratinib for labeled myelofibrosis; selected renal dose and monitoring.

Renal method: Cockcroft-Gault CrCl in mL/min.
Source date: Source revision date not established in selected retrieval.
Retrieved: 2026-09-07

Label mirror, not independent corroboration. This is selected locally stored RX List content. Full monograph import and current official-label review are not implied.
Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.

Renal dosing, restrictions and evidence limits

At CrCl 15-29 mL/min, reduce to 200 mg orally once daily. No renal starting-dose change is recommended at CrCl 30-89, but moderate impairment requires more intensive adverse-effect monitoring and later toxicity-based changes when needed. Baseline and ongoing thiamine, blood counts, kidney/liver tests and pancreatic enzymes remain relevant. No regimen is extrapolated below 15 mL/min or to dialysis from these bands.

RDM43-rxlist-fedratinib-inrebic-2faea421ae-C1 · Source locator: Selected Dosage / Renal Impairment / Warnings sections; see source-specific qualifications in this summary.

Source identity and provenance
Source family
product_label_mirror
Source
https://globalrph.com/rx-list/inrebic-drug/
Retrieved
2026-09-07
Renal-function method
Cockcroft-Gault CrCl in mL/min.
Source date/version
Source revision date not established in selected retrieval.
Hash meaning
SHA-256 of local authored summary only; not original HTML, PDF or SPL bytes.
Local summary SHA-256
7809a0c5f0b99963022ba4550920a622fee5fae962c95816ddcc327d6806571a

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 2 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://globalrph.com/rx-list/inrebic-drug/
Source retrieval
2026-09-07. This is not the source publication or label revision date.
Original source type
rxlist summary
Local text SHA-256
977d3444d20650eea200b43a695d7bb0e5020483a70f674e68850351b5053fb5
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

This page is an additional exact-product entry, not a recovered GlobalRPh monograph. Its primary scope text and separately attributed clinical summaries are locally included.

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