GlobalRPh Renal Dosing Masterv6.6
GlobalRPh source record

Ethambutol

GlobalRPh source pageBase record retrieved 2026-09-05See the evidence for this drug3 sources available - open source summaries, references and comparisons
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Professional source

UCSF - ethambutol: TB and MAC

Product / population
Adults; source-specific institutional guidance. Match route, indication and renal replacement modality.
Renal measure
CrCl in mL/min where specified; no equation inferred.

Dosing / renal protocol and limits

For tuberculosis at CrCl >30 mL/min, 20-24 mg/kg orally daily; below 30, the same dose three times weekly. The source limits the usual starting dose to 1600 mg and recommends ID input above 80 kg. MAC: 15 mg/kg daily when CrCl >30, or three times weekly below 30. Exactly 30 is not assigned by the displayed bands.

Intermittent HD: give the TB dose of 20-24 mg/kg initially and after HD; for MAC, 15 mg/kg initially and after HD. Continuous HD: TB 15-20 mg/kg daily; MAC 15 mg/kg daily. Consider therapeutic drug monitoring.

Use adjusted body weight with BMI >30 kg/m2; otherwise actual weight. These are combination-treatment regimens.

Source revision: Page identifies TB institutional practice as of May 2025 and dialysis information as of May 2023. | Retrieved: 2026-09-05. Retrieval date is not the revision date.

Source: https://idmp.ucsf.edu/content/ethambutol

Scope: Locally included source-specific summary. Regimen differences are not automatically resolved. GlobalRPh v6.6.

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Retrieved: 2026-09-05

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Professional guidance

UCSF - ethambutol: TB and MAC

Adults; source-specific institutional guidance. Match route, indication and renal replacement modality.

Renal method: CrCl in mL/min where specified; no equation inferred.
Retrieved: 2026-09-05

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Original content / product scopeNIH OI: EthambutolUCSF - ethambutol: TB and MAC
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Historical source content is not a current prescription. Original GlobalRPh recommendations are preserved, not automatically certified as current. Product-label and professional additions below are separately attributed. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.
Locally stored source content

Original GlobalRPh protocol

Clinical facts and comments transcribed into a structured reading format. This is not a byte-for-byte HTML archive. Original source: https://globalrph.com/renal/ethambutol/

Usual Dosing (Adults)

15 to 25 mg/kg every 24 hours; maximum 2500 mg/day.

GRPH-ethambutol-01 · Source section: Usual Dosing (Adults)Renal section finder

Renal Dosing

CrCl >50 mL/min: no change; 10 to 50: normal dose every 24 to 36 hours; <10: normal dose every 48 hours.

GRPH-ethambutol-02 · Source section: Renal DosingRenal section finder

Hemodialysis

Normal dose every 48 hours. On dialysis days, give after dialysis.

GRPH-ethambutol-03 · Source section: HemodialysisRenal section finder
Separate professional-source layer

University and professional protocols

Professional

NIH OI: Ethambutol

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NIH ClinicalInfo · Adults with HIV.

Renal method: NIH table: CrCl or eGFR; not interchangeable. Not CRRT.
Source date: Updated April 23, 2025; reviewed March 16, 2026
Retrieved: 2026-09-05

Source-read local summary; source-specific recommendations are not automatically interchangeable.

Dose and kidney adjustment

MAI: 15 mg/kg orally daily; MTB: 15-25 mg/kg daily, in combination regimens. Renal estimate <30 mL/min or intermittent HD: the same indication-specific dose three times weekly, after HD. Use therapeutic drug monitoring.

ethambutol:nih-oi-ethambutol-1 · Source locator: Table 6: Ethambutol row

Source identity and provenance
Source
https://clinicalinfo.hiv.gov/en/guidelines/hiv-clinical-guidelines-adult-and-adolescent-opportunistic-infections/dosing-recommendations-drugs-used
Retrieved
2026-09-05
Renal-function method
NIH table: CrCl or eGFR; not interchangeable. Not CRRT.
Source date/version
Updated April 23, 2025; reviewed March 16, 2026
Hash meaning
Locally authored source summary, not original SPL/XML/PDF bytes
Local summary SHA-256
c04d539bf5b02bff6e1eaf2aafaacaf89c6d94dd8762adfc488abf842c93d9f3
Professional

UCSF - ethambutol: TB and MAC

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UCSF Infectious Diseases Management Program · Adults; source-specific institutional guidance. Match route, indication and renal replacement modality.

Renal method: CrCl in mL/min where specified; no equation inferred.
Source date: Page identifies TB institutional practice as of May 2025 and dialysis information as of May 2023.
Retrieved: 2026-09-05

Locally included source-specific summary. Regimen differences are not automatically resolved.

Dosing / renal protocol and limits

For tuberculosis at CrCl >30 mL/min, 20-24 mg/kg orally daily; below 30, the same dose three times weekly. The source limits the usual starting dose to 1600 mg and recommends ID input above 80 kg. MAC: 15 mg/kg daily when CrCl >30, or three times weekly below 30. Exactly 30 is not assigned by the displayed bands.

Intermittent HD: give the TB dose of 20-24 mg/kg initially and after HD; for MAC, 15 mg/kg initially and after HD. Continuous HD: TB 15-20 mg/kg daily; MAC 15 mg/kg daily. Consider therapeutic drug monitoring.

Use adjusted body weight with BMI >30 kg/m2; otherwise actual weight. These are combination-treatment regimens.

RDM30-030-ethambutol-1 · Source locator: UCSF - ethambutol: TB and MAC; renal/dosing sections and stated qualifiers

Source identity and provenance
Source
https://idmp.ucsf.edu/content/ethambutol
Retrieved
2026-09-05
Renal-function method
CrCl in mL/min where specified; no equation inferred.
Source date/version
Page identifies TB institutional practice as of May 2025 and dialysis information as of May 2023.
Hash meaning
Locally authored summary text; not original SPL, HTML or PDF bytes
Local summary SHA-256
d9f4aa156217fe0084010c11094012580cea3a5ab6bae126a8206363330ddde0

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 0 RX List, 2 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://globalrph.com/renal/ethambutol/
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
globalrph individual
Local text SHA-256
f44edff282729b0c212979f67fc74a032c710e290b959bb1d68fb28a4e2faa10
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

The original individual GlobalRPh pages commonly cite NIH/NLM DailyMed and instruct readers to review the applicable package insert for updates. That historical reference is preserved as context; it is not counted as an independently retrieved current label.

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