Original GlobalRPh source
- Product / population
- Preserved GlobalRPh source, not a freshly verified product label
- Renal measure
- Use the method specified in the original source
Historical source: not automatically current. Review current official labeling and separately attributed additions before use.
Usual Dosing (Adults)
Hip/knee surgery DVT prophylaxis: 30 mg subcutaneously every 12 hours starting 12 to 24 hours postoperatively. Hip alternative: 40 mg subcutaneously daily starting 12 hours preoperatively. Outpatient DVT treatment: 1 mg/kg subcutaneously every 12 hours until oral anticoagulation is established. Inpatient DVT: 1 mg/kg every 12 hours or 1.5 mg/kg daily. Unstable angina/non-Q-wave MI: 1 mg/kg every 12 hours. High-risk acutely ill medical prophylaxis: 40 mg daily for 6 to 11 days, up to 14 days.
Renal Dosing
CrCl >30 mL/min: no specific manufacturer adjustment. CrCl <30: prophylaxis in abdominal surgery, hip/knee replacement or acute medical illness, 30 mg subcutaneously daily; DVT treatment in conjunction with warfarin, 1 mg/kg subcutaneously every 24 hours; unstable angina/non-Q-wave MI with aspirin, 1 mg/kg every 24 hours.
Hemodialysis
The source states enoxaparin has not been FDA approved for dialysis use, is primarily renally eliminated, and serious bleeding has been reported in dialysis-dependent or severe renal failure patients.