GlobalRPh Renal Dosing Masterv7.4
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Enalapril

Read renal action and limits
Local official-label summarySource retrieved 2026-09-05See the evidence for this drug3 sources available - open source summaries, references and comparisons

Vasotec / Enalapril maleate

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Renal guidance at a glance

Cautions / source differences (1)

Use the renal measure and units named by this source. Confirm product, indication, age, stable versus changing kidney function, and exact dialysis modality. The selected summary is not a complete prescribing monograph. Renal method and dosing checklist

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Display order is not a clinical ranking. Date of retrieval is not the label revision date. Sources are never merged into one regimen. Other sources and conflicts remain below.

1 additional source qualifications - review before use
Vasotec - product and source limitations

Dialysis days, heart failure, baseline hypotension and diuretic use have separate considerations.

Before applying: Apply only to the stated formulation, indication and renal population.

Also check: Vasotec - product and source limitations

Official source

Vasotec - labeled renal guidance

Renal action and limits

Enalapril maleate (Vasotec), oral tablet
Creatinine clearance (CrCl), mL/min

Action or finding
For adult hypertension with CrCl 30 mL/min or less, the recommended first oral enalapril dose is 2.5 mg once daily. Above 30, the usual initial regimen applies.
Limits and monitoring
Dialysis days, heart failure, baseline hypotension and diuretic use have separate considerations.
Before use
Apply only to the stated formulation, indication and renal population.

DailyMed SPL version 15, posted Jan 28, 2026 | Selected sections checked 2026-11-07. Independent clinical review pending.

Choose a product and source Vasotec | GlobalRPh RX passage All evidence
Product / population
Enalapril maleate (Vasotec), oral tablet
Renal measure
Creatinine clearance (CrCl), mL/min
Source revision
DailyMed SPL version 15, posted Jan 28, 2026
Retrieved
2026-11-07 (not the revision date)
Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Renal guidance: Dual Blockade of the Renin-Angiotensin System (RAS)

For adult hypertension with CrCl 30 mL/min or less, the recommended first oral enalapril dose is 2.5 mg once daily. Above 30, the usual initial regimen applies. Dialysis days, heart failure, baseline hypotension and diuretic use have separate considerations.

Source revision: DailyMed SPL version 15, posted Jan 28, 2026 | Retrieved: 2026-11-07. Retrieval date is not the revision date.

Source: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=39631f1f-5d19-43c1-b504-bf56d991ed97

Scope: Selected renal passages reviewed; independent clinician adjudication pending. GlobalRPh v7.4.

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Added / rechecked in v7.4

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Official

Vasotec - labeled renal guidance

Retrieved: 2026-11-07
Source revision: DailyMed SPL version 15, posted Jan 28, 2026

Renal measure: Creatinine clearance (CrCl), mL/min

Read this dated source finding
Rxlist

Vasotec - selected RX renal passage

Retrieved: 2026-11-07
Source revision: Mirror revision not established in the reviewed passage.

Renal measure: Use the renal measure explicitly present in the RX passage.

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Source-first renal review

Evidence sources and renal implications

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GlobalRPh RX List

Vasotec - selected RX renal passage

Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Enalapril maleate (Vasotec), oral tablet

Renal method: Use the renal measure explicitly present in the RX passage.
Retrieved: 2026-11-07

Read local renal resultOpen this source quick answerOpen original reference

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Source-specific review points

Vasotec - product and source limitations

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Source scope / renal recommendation differences

Vasotec - product and source limitations

Dialysis days, heart failure, baseline hypotension and diuretic use have separate considerations.

How to use this: Apply only to the stated formulation, indication and renal population.

Vasotec - labeled renal guidanceVasotec - selected RX renal passage

Selected renal passages reviewed; independent clinician adjudication pending.

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Renal dosing and precautions

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Independent clinical review is pending. These selected summaries are not an approved institutional dosing protocol. Confirm the exact product, the complete current source and local policy before use.

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Original content / product scopeVasotec - labeled renal guidanceVasotec - selected RX renal passage
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Historical source content is not a current prescription. Original GlobalRPh recommendations are preserved, not automatically certified as current. Product-label and professional additions below are separately attributed. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.
Locally stored source content

Original GlobalRPh protocol

Clinical facts and comments transcribed into a structured reading format. Read the original source for its complete context: https://globalrph.com/renal/enalapril/

Usual Dosing (Adults)

Hypertension: an initial dose can cause symptomatic hypotension with concomitant diuretics. If possible, stop the diuretic for 2 to 3 days before enalapril and resume if needed for control. If the diuretic cannot be stopped, start 2.5 mg under medical supervision for at least 2 hours and until pressure is stable for at least an additional hour.

Without a diuretic: initial 5 mg daily, adjust to blood pressure. Usual 10 to 40 mg/day in one or two doses. If effect diminishes before the next daily dose, consider a dose increase or twice-daily dosing. Add a diuretic if required.

Symptomatic heart failure: usually in combination with diuretics/digitalis. Survival studies titrated as tolerated up to 40 mg/day in two doses. Initial 2.5 mg; recommended 2.5 to 20 mg twice daily, titrated over days/weeks. Trial maximum 40 mg/day in divided doses.

Asymptomatic LV dysfunction: trial initial 2.5 mg twice daily to a target of 20 mg/day in divided doses. After the first dose, observe at least 2 hours and until blood pressure is stable for another hour.

GRPH-enalapril-01 · Source section: Usual Dosing (Adults)Renal section finder

Renal Dosing

Hypertension: CrCl >30 mL/min (serum creatinine approximately up to 3 mg/dL), usual dose. CrCl <=30 (source creatinine >=3 mg/dL), start 2.5 mg once daily, titrating until blood pressure control or maximum 40 mg/day.

Renal statusCrClInitial dose
Normal>80 mL/min5 mg/day
Mild impairment>30 to <=805 mg/day
Moderate/severe<=302.5 mg/day
DialysisNot specified2.5 mg on dialysis days; adjust nondialysis-day dose to blood pressure
GRPH-enalapril-02 · Source section: Renal DosingRenal section finder

Hemodialysis

See the dialysis-day and blood-pressure instructions above.

GRPH-enalapril-03 · Source section: HemodialysisRenal section finder
Separate U.S. product-label layer

FDA / DailyMed dosing and renal information

Official

Vasotec - labeled renal guidance

Open original reference

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DailyMed / product prescribing information · Enalapril maleate (Vasotec), oral tablet

Renal method: Creatinine clearance (CrCl), mL/min
Source date: DailyMed SPL version 15, posted Jan 28, 2026
Retrieved: 2026-11-07

Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Selected renal passages reviewed; independent clinician adjudication pending.

Renal guidance: Dual Blockade of the Renin-Angiotensin System (RAS)

For adult hypertension with CrCl 30 mL/min or less, the recommended first oral enalapril dose is 2.5 mg once daily. Above 30, the usual initial regimen applies. Dialysis days, heart failure, baseline hypotension and diuretic use have separate considerations.

RDM74-vasotec-official-1 · Source locator: Renal guidance: Dual Blockade of the Renin-Angiotensin System (RAS)

Source identity and provenance
Source family
product_label
Source
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=39631f1f-5d19-43c1-b504-bf56d991ed97
Retrieved
2026-11-07
Renal-function method
Creatinine clearance (CrCl), mL/min
Source date/version
DailyMed SPL version 15, posted Jan 28, 2026
Hash meaning
SHA-256 of the local selected-source summary
Local summary SHA-256
9f3a385a5538005d9ecb6f984b1929531938b1358d25b170922b9e5dfa1dc3cb
Locally imported selected renal sections

GlobalRPh RX List renal information

Rxlist

Vasotec - selected RX renal passage

Open original reference

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GlobalRPh RX List / product-label mirror · Enalapril maleate (Vasotec), oral tablet

Renal method: Use the renal measure explicitly present in the RX passage.
Source date: Mirror revision not established in the reviewed passage.
Retrieved: 2026-11-07

Label mirror, not independent corroboration. This is selected locally stored RX List content. Full monograph import and current official-label review are not implied.
Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Selected renal passages reviewed; independent clinician adjudication pending.

RX List: selected renal passage

The mirror reduces the initial oral dose for the lower CrCl group.

RDM74-vasotec-rxlist-1 · Source locator: RX List: selected renal passage

Source-specific limits

This mirror and the underlying product label share a source family.

Source identity and provenance
Source family
product_label_mirror
Source
https://globalrph.com/rx-list/vasotec-drug/
Retrieved
2026-11-07
Renal-function method
Use the renal measure explicitly present in the RX passage.
Source date/version
Mirror revision not established in the reviewed passage.
Hash meaning
SHA-256 of the local selected-source summary
Local summary SHA-256
8f622d3c8caaef1da6780ead55943c41ca7035ee4dcf8b9cd98e43e2bc3aa385

Provenance and preservation

Additional summaries stored on this page: 1 official-label, 1 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://globalrph.com/renal/enalapril/
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
globalrph individual
Local text SHA-256
9ebaaed84554bc243e5c51370902373ccc3fd28e40c2d9d35f45f7c18b7ce424
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

The original individual GlobalRPh pages commonly cite NIH/NLM DailyMed and instruct readers to review the applicable package insert for updates. That historical reference is preserved as context; it is not counted as an independently retrieved current label.

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