Use the renal measure and units named by this source. Confirm product, indication, age, stable versus changing kidney function, and exact dialysis modality. The selected summary is not a complete prescribing monograph. Renal method and dosing checklist
Choose a source to read (4)
Display order is not a clinical ranking. Date of retrieval is not the label revision date. Sources are never merged into one regimen. Other sources and conflicts remain below.
1 additional source qualifications - review before use
Historical renal/RRT cross-check for the named ingredient; not a current U.S. prescribing instruction.
Renal measure
Book table headings say GFR (mL/min); the preface states adjustment information is based on Cockcroft-Gault CrCl, not indexed eGFR. Do not substitute methods.
Source revision
Fifth edition, 2019
Retrieved
2026-09-05 (not the revision date)
The dialysis statements are the book's historical assessment; the label study is not a dialysis efficacy study.
Historical renal and dialysis observations
The historical 20-50, 10-20 and below-10 mL/min bands all retain usual dosing. Peritoneal, conventional HD and continuous removal are described as unlikely; high-flux/HDF removal is unknown. No reduction is proposed for those modalities.
Source revision: Fifth edition, 2019 | Retrieved: 2026-09-05. Retrieval date is not the revision date.
Source:
Scope: Historical source, separately displayed. Renal tables were read with page-image inspection. GlobalRPh v7.4.
All sources, comparison tools and evidence navigation
Source-first renal review
Evidence sources and renal implications
Choose a source to jump directly to its locally stored result. Qualitative precautions and evidence gaps remain visible even when no numerical clearance schedule is supplied.
Renal Drug Handbook, fifth edition - Donepezil tablets (mild to moderate Alzheimer disease)
Historical renal/RRT cross-check for the named ingredient; not a current U.S. prescribing instruction.
Renal method: Book table headings say GFR (mL/min); the preface states adjustment information is based on Cockcroft-Gault CrCl, not indexed eGFR. Do not substitute methods. Retrieved: 2026-09-05
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All source summaries, original wording and provenance
Before applying a renal protocol
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No patient-specific dose is calculated. Context choices only display reminders; they do not validate, hide or change any regimen.
Share a reproducible source review
Choose sources below, then open a print-ready comparison with product scope, renal method, dates and cautions. Links can pin the exact local cards; they never contain patient values or choose a dose.
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Source-by-source comparison
These protocols may disagree and may apply to different settings. This view does not reconcile or endorse a patient-specific regimen.
Build a source-review outline for documentation
This creates a blank decision outline with the source identities you select, not a dose recommendation or completed clinical assessment. No patient fields are collected, saved or sent. Complete the clinical decisions in your approved documentation system.
Choose one or two sources above or use the source checkboxes below.
Renal-context checklist: population, kidney trend and dialysis
These prompts are a reading aid, not a prescription checklist or proof that all requirements have been met. No selections are stored or sent to a server.
Read the exact source scope, renal metric and date before selecting a row. No applicability assessment has been performed.
These are specific issues found during source review, not an automated judgment that one source is universally correct. A label mirror and its original label are not independent evidence.
Source scope / renal recommendation differences
Aricept - product and source limitations
This finding does not establish a hemodialysis dose or timing rule.
How to use this: Apply only to the stated formulation, indication and renal population.
Choose a source, then jump to its renal or dialysis section. These links locate stored text; they do not merge regimens or certify that sources agree.
Independent clinical review is pending. These selected summaries are not an approved institutional dosing protocol. Confirm the exact product, the complete current source and local policy before use.
Official source
Donepezil tablets (mild to moderate Alzheimer disease) - selected U.S. labeling
Adults with mild to moderate Alzheimer disease; oral 5 mg and 10 mg tablets. This summary excludes the 23 mg regimen and transdermal formulations.
Method: Indexed clearance in the label pharmacokinetic study; not an automatic renal dose-selection equation.
Renal Drug Handbook, fifth edition - Donepezil tablets (mild to moderate Alzheimer disease)
Historical renal/RRT cross-check for the named ingredient; not a current U.S. prescribing instruction.
Method: Book table headings say GFR (mL/min); the preface states adjustment information is based on Cockcroft-Gault CrCl, not indexed eGFR. Do not substitute methods.
No dialysis or renal heading shown? Read the complete source summary. Absence of a heading is not evidence that dose adjustment is unnecessary.
Compare or copy source versions
All content below is stored locally. Read a whole source version; do not combine its dose with another source's interval, renal metric or dialysis assumptions.
Exact product and population matter. This added page contains locally stored, source-specific clinical summaries. Historical handbook information, when present, is identified separately and may conflict with U.S. labeling. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.
U.S. product labeling / DailyMed · Adults with mild to moderate Alzheimer disease; oral 5 mg and 10 mg tablets. This summary excludes the 23 mg regimen and transdermal formulations.
Renal method: Indexed clearance in the label pharmacokinetic study; not an automatic renal dose-selection equation. Source date: Label revision date not separately recorded; retrieval date is not the revision date. Retrieved: 2026-09-05
Selected dosing/renal sections read; concise local summary, not full prescribing information.
Labeled basic dosing
Start 5 mg orally each evening. A 10 mg daily dose may be used only after 4-6 weeks at 5 mg; 10 mg/day is the labeled maximum for this disease-severity scope.
A study of 11 subjects with renal clearance below 18 mL/min/1.73 m2 found no difference in donepezil clearance versus matched controls. No separate numeric renal or dialysis regimen is given in the selected label.
Monitor for bradycardia/heart block, syncope, gastrointestinal adverse effects and weight loss. Do not transfer this titration to another dosage form or disease-severity regimen.
A small PK comparison found similar donepezil clearance in 11 patients with CrCl <18 mL/min/1.73 m2 and 11 matched controls. This finding does not establish a hemodialysis dose or timing rule.
GlobalRPh RX List / product-label mirror · Donepezil (Aricept), oral tablets for adults
Renal method: Use the renal measure explicitly present in the RX passage. Source date: Mirror revision not established in the reviewed passage. Retrieved: 2026-11-07
Label mirror, not independent corroboration. This is selected locally stored RX List content. Full monograph import and current official-label review are not implied.
Pharmacokinetic observation only. A drug-exposure observation is not itself a dose recommendation.
UK Renal Pharmacy Group / CRC Press · Historical renal/RRT cross-check for the named ingredient; not a current U.S. prescribing instruction.
Renal method: Book table headings say GFR (mL/min); the preface states adjustment information is based on Cockcroft-Gault CrCl, not indexed eGFR. Do not substitute methods. Source date: Fifth edition, 2019 Retrieved: 2026-09-05
Historical source, separately displayed. Renal tables were read with page-image inspection.
Historical renal and dialysis observations
The historical 20-50, 10-20 and below-10 mL/min bands all retain usual dosing. Peritoneal, conventional HD and continuous removal are described as unlikely; high-flux/HDF removal is unknown. No reduction is proposed for those modalities.
RDM31-donepezil-tablets-book · Source locator: Dose in renal impairment; renal replacement therapies; Other information
Source-specific limits
The dialysis statements are the book's historical assessment; the label study is not a dialysis efficacy study.
Source identity and provenance
Retrieved
2026-09-05
Handbook page
Printed page(s) 335; PDF page(s) 354
Renal-function method
Book table headings say GFR (mL/min); the preface states adjustment information is based on Cockcroft-Gault CrCl, not indexed eGFR. Do not substitute methods.
Additional summaries stored on this page: 2 official-label, 1 RX List, 0 professional, 1 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.
This page is an additional exact-product entry, not a recovered GlobalRPh monograph. Its primary scope text and separately attributed clinical summaries are locally included.
