GlobalRPh Renal Dosing Masterv6.6
GlobalRPh source record

Dofetilide (Tikosyn)

GlobalRPh source pageBase record retrieved 2026-09-05See the evidence for this drug1 sources available - open source summaries, references and comparisons
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The original QTc phrase >15% of baseline is ambiguous and is preserved rather than silently converted to a current-label algorithm. This excerpt alone is not the complete monitored initiation protocol.

Usual Dosing (Adults)

TIKOSYN is indicated to maintain normal sinus rhythm/delay recurrence in patients with AF/flutter lasting >1 week who have converted to sinus rhythm, and for conversion of AF/flutter. Because of life-threatening ventricular arrhythmias, reserve for highly symptomatic AF/flutter. Antiarrhythmic treatment aims to prolong sinus rhythm; recurrence is expected in some. It has not shown effectiveness for paroxysmal AF.

The source lists 500 micrograms orally twice daily initially, with lower doses at physician discretion and renal doses below. Measure QTc 2 to 3 hours after the first dose. The source wording is "If the QTc >15% of baseline, or if the QTc is >500 msec (550 msec in patients with ventricular conduction abnormalities), dofetilide should be adjusted." For inpatient doses 2 through 5, measure QTc 2 to 3 hours after each dose; stop if QTc >500 ms (550 ms with ventricular conduction abnormalities).

Renal Dosing

CrCl >60 mL/min: 500 micrograms twice daily; 40 to 60: 250 micrograms twice daily; 20 to 39: 125 micrograms twice daily; <20: contraindicated.

Hemodialysis

Contraindicated.

Source revision: Historical source; revision not established here | Retrieved: 2026-09-05. Retrieval date is not the revision date.

Source: https://globalrph.com/renal/dofetilide/

Scope: Preserved historical source; no fresh clinical approval GlobalRPh v6.6.

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Retrieved: 2026-09-05

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Important source distinctions

The original QTc phrase >15% of baseline is ambiguous and is preserved rather than silently converted to a current-label algorithm. This excerpt alone is not the complete monitored initiation protocol.

Locally stored source content

Original GlobalRPh protocol

Clinical facts and comments transcribed into a structured reading format. This is not a byte-for-byte HTML archive. Original source: https://globalrph.com/renal/dofetilide/

Usual Dosing (Adults)

TIKOSYN is indicated to maintain normal sinus rhythm/delay recurrence in patients with AF/flutter lasting >1 week who have converted to sinus rhythm, and for conversion of AF/flutter. Because of life-threatening ventricular arrhythmias, reserve for highly symptomatic AF/flutter. Antiarrhythmic treatment aims to prolong sinus rhythm; recurrence is expected in some. It has not shown effectiveness for paroxysmal AF.

The source lists 500 micrograms orally twice daily initially, with lower doses at physician discretion and renal doses below. Measure QTc 2 to 3 hours after the first dose. The source wording is "If the QTc >15% of baseline, or if the QTc is >500 msec (550 msec in patients with ventricular conduction abnormalities), dofetilide should be adjusted." For inpatient doses 2 through 5, measure QTc 2 to 3 hours after each dose; stop if QTc >500 ms (550 ms with ventricular conduction abnormalities).

GRPH-dofetilide-01 · Source section: Usual Dosing (Adults)Renal section finder

Renal Dosing

CrCl >60 mL/min: 500 micrograms twice daily; 40 to 60: 250 micrograms twice daily; 20 to 39: 125 micrograms twice daily; <20: contraindicated.

GRPH-dofetilide-02 · Source section: Renal DosingRenal section finder

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 0 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://globalrph.com/renal/dofetilide/
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
globalrph individual
Local text SHA-256
eeacd9573f0bc23318a31a5d561bb0572c5bdc9b396307edb6775527ebf160a0
Import versus clinical validation
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The original individual GlobalRPh pages commonly cite NIH/NLM DailyMed and instruct readers to review the applicable package insert for updates. That historical reference is preserved as context; it is not counted as an independently retrieved current label.

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