Dapagliflozin / saxagliptin / metformin XR (QTERNMET XR)

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Do not borrow a single-agent SGLT2 renal threshold for a combination

This fixed combination includes saxagliptin and metformin. Its selected label version has a product-specific renal restriction; a lower threshold for a different dapagliflozin indication does not override it.

Before applying: Confirm every ingredient, current combination label, indication and initiation versus continuation decision. The locally retained QTERNMET XR source is dated May 2019, not a current-label attestation.

Also check: Do not borrow a single-agent SGLT2 renal threshold for a combination

Rxlist source

GlobalRPh RX List - QTERNMET XR

Product / population: Adults with type 2 diabetes; fixed dapagliflozin/saxagliptin/metformin extended-release tablets, not the separate agents.
Renal measure: Indexed eGFR, mL/min/1.73 m2.

RX mirror: this is not independent corroboration of its underlying label. Check dated-label and formulation limitations.

Renal dosing, restrictions and evidence limits

This May 2019 source permits no renal dosage modification at eGFR at least 45 mL/min/1.73 m2 and contraindicates this fixed combination below 45. Assess renal function before use and periodically, and correct volume depletion. The contrast section directs interruption for the specified liver disease, alcoholism, heart-failure or intra-arterial-contrast circumstances, with renal reassessment after 48 hours before restarting if stable. The three-component restriction must not be replaced by a single component's renal indication or threshold. Current labeling and availability require reconciliation before prescribing from this older source.

Source revision: May 2019 | Retrieved: 2026-09-07. Retrieval date is not the revision date.

Source: https://globalrph.com/rx-list/qternmet-xr-drug/

Scope: Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph. GlobalRPh v6.6.

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GlobalRPh RX List

GlobalRPh RX List - QTERNMET XR

Restriction or avoidance guidance. Read the specific threshold, age, formulation and dialysis exclusions; do not generalize across products.

Adults with type 2 diabetes; fixed dapagliflozin/saxagliptin/metformin extended-release tablets, not the separate agents.

Renal method: Indexed eGFR, mL/min/1.73 m2.
Retrieved: 2026-09-07

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combination product scope

Do not borrow a single-agent SGLT2 renal threshold for a combination

How to use this: Confirm every ingredient, current combination label, indication and initiation versus continuation decision. The locally retained QTERNMET XR source is dated May 2019, not a current-label attestation.

GlobalRPh RX List - QTERNMET XR Dapagliflozin/saxagliptin (QTERN)Dapagliflozin/metformin extended-release (XIGDUO XR)Dapagliflozin (Farxiga)

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Renal dosing and precautions

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Rxlist source

GlobalRPh RX List - QTERNMET XR

Adults with type 2 diabetes; fixed dapagliflozin/saxagliptin/metformin extended-release tablets, not the separate agents.

Method: Indexed eGFR, mL/min/1.73 m2.

Renal dosing, restrictions and evidence limits Read this complete source summary

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Original content / product scope GlobalRPh RX List - QTERNMET XR

Exact product and population matter. This added page contains locally stored, source-specific clinical summaries. Historical handbook information, when present, is identified separately and may conflict with U.S. labeling. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.

Locally stored source content

Exact product and population

Product identity selected for the separately displayed source protocols below. Reference: https://globalrph.com/rx-list/qternmet-xr-drug/

Exact product and population

Adults with type 2 diabetes; fixed dapagliflozin/saxagliptin/metformin extended-release tablets, not the separate agents.

RDM35-SCOPE-dapagliflozin-saxagliptin-metformin-qternmet-xr · Source section: Selected source product scopeRenal section finder

Locally imported selected renal sections

GlobalRPh RX List renal information

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GlobalRPh RX List - QTERNMET XR

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GlobalRPh-hosted RX List · Adults with type 2 diabetes; fixed dapagliflozin/saxagliptin/metformin extended-release tablets, not the separate agents.

Renal method: Indexed eGFR, mL/min/1.73 m2.
Source date: May 2019
Retrieved: 2026-09-07

Label mirror, not independent corroboration. This is selected locally stored RX List content. Full monograph import and current official-label review are not implied.

Restriction or avoidance guidance. Read the specific threshold, age, formulation and dialysis exclusions; do not generalize across products.

Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.

Renal dosing, restrictions and evidence limits

RDM35-rxlist-dapagliflozin-saxagliptin-metformin-qternmet-xr-ce74b64e8c-C1 · Source locator: Dosage: Patients With Renal Impairment and Discontinuation for Iodinated Contrast; source revision.

Source identity and provenance

Source family: product_label_mirror
Source: https://globalrph.com/rx-list/qternmet-xr-drug/
Retrieved: 2026-09-07
Renal-function method: Indexed eGFR, mL/min/1.73 m2.
Source date/version: May 2019
Hash meaning: SHA-256 of local authored summary only; not original HTML, PDF or SPL bytes.
Local summary SHA-256: 1c41a77a488ea4f722faf606703a7f47dcac4a7dd046fb13ab991637328bf36f

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 1 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source: https://globalrph.com/rx-list/qternmet-xr-drug/
Source retrieval: 2026-09-07. This is not the source publication or label revision date.
Original source type: rxlist summary
Local text SHA-256: 0d4b328b5b7026e5995f19fefd6b6fdde04ef5fe3c9406ae11e33b9bd8ee46b1
Import versus clinical validation: Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

This page is an additional exact-product entry, not a recovered GlobalRPh monograph. Its primary scope text and separately attributed clinical summaries are locally included.

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